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Safe And Effective Treatment For Acute Repetitive Seizures

rketed in a Quick-Dose (TM) delivery system as Diastat (diazepam rectal gel) by Athena Neurosciences, Inc., a company based in South San Francisco. In addition to the new gel formulation, administered with an applicator, diazepam is also sold in oral form. Administration of diazepam in oral form is problematic for both physicians and family members because the patient must be alert in order to swallow.

"This is a safe and effective way of addressing an urgent health condition and one that enables flexible, convenient treatment outside of a hospital or clinic, including the patient's home," says Dr. Sheridan. "This trial is a striking example of how a relatively small research investment, in this case about $850,000, will save American families substantial amounts of money by enabling patients to stay out of hospital emergency rooms and to receive treatment in their homes. It is also an excellent example of collaboration between a private company, clinical investigators, and the National Institutes of Health in order to meet a medical need."

The NINDS, one of the National Institutes of Health located in Bethesda, Maryland, is the nation's leading supporter of research on the brain and the nervous system and a lead agency for the Congressionally designated Decade of the Brain.

*Dreifuss, F.E. [deceased], Rosman, N.P., Cloyd, J.C., Pellock, J.M., Kuzniecky, R.I., Lo, W.D., Matsuo, F., Sharp, G.B., Conry, J.A., Bergen, D.C., Bell, W.E. "A Comparison of Rectal Diazepam Gel and Placebo for Acute Repetitive Seizures." The New England Journal of Medicine, June 25, 1998, Vol. 338, No. 26, pp. 1869-1875.

This release will be available on the World Wide Web at http://www.ninds.nih.gov.


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Contact: Stephanie Clipper
301/496-5751
NIH/National Institute of Neurological Disorders and Stroke
24-Jun-1998


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