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Scientist explain a drug's paradoxical action: discovery may lead to new therapies for breast cancer, early puberty

rol," Auchus explained. "The value of using yeast cells, instead of human cells, for these studies is that we can put in known amounts of the enzyme, the cholesterol and all the proteins the enzyme has to interact with, to work out the individual biochemical steps in the enzyme's action.

"With this system we can ask questions about how human adrenal glands and gonads make hormones," Auchus said. "We don't know, for example, how a cell in the testes or the ovaries decides to make one steroid as opposed to another. The yeast system will permit us for the first time to work this out with rigor." Auchus, Miller and Lee first used "humanized" yeast to study the biochemistry of the key cholesterol-converting enzyme cytochrome P450c17. The group's paper on the biochemical activity of cytochrome P450c17 was published in February, 1998 in the Journal of Biological Chemistry.

REPORTERS' NOTE: For more information about the work of the Miller lab, see their website at http://itsa.ucsf.edu/~wlmlab/


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Contact: Janet Basu
jbasu@pubaff.ucsf.edu
415-476-2557
University of California - San Francisco
8-Jun-1999


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