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Scientist show how viruses co-opt cell defenses to cause chronic infections likethose from HIV and Hepatitis B and C

Scientists at the University of California, San Francisco and the UCSF-affiliated San Francisco General Medical Center have developed a model to study at the cellular level how viruses like HIV and Hepatitis B and C evade and co-opt the defense strategies of the cells they invade to cause chronic infections.

In a study reported in the Proceedings of the National Academy of Sciences, a group led by Allan Lau, and Michael Yeung, scientists in the Department Of Pediatrics at UCSF, has shown that a virus can establish a persistent infection if it can overcome cell suicide, an important host defense. And they have shown that once the virus establishes a lasting presence in the host's cells, physiological changes begin. The cells grow more slowly and the virus becomes less infectious over time -- evidence of co-evolution for the virus and its host.

The discovery could lead to methods to find new antiviral agents, to boost the effectiveness of antiviral drugs - and possibly to end Hepatitis C and other persistent viral infections.

Most viral infections begin with a virulent phase straight out of science fiction: The virus invades and kills cells, the immune system mounts a response to keep it from invading further and the infected person suffers misery as a result. Some viruses later change their tactics from invader to dominator. The virus takes over part of the cell's machinery and dwells there, becoming a persistent infection. Persistent viral infections can continue for life and wreak slow havoc, as HIV does to the immune system and Hepatitis B and C do to the liver.

Now Lau, Yeung and their colleagues have taken a virulent, cell-killing virus and converted it to a persistently infective virus. They turned off the host cell's last-ditch defense mechanism, which normally attempts to stop the viral invasion by a process of programmed destruction called apoptosis -- cell suicide.

In the initial experiments that led to this model, Lau said, th
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Contact: Janet Basu
jbasu@pubaff.ucsf.edu
415-476-2557
University of California - San Francisco
11-Oct-1999


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