HOME >> MEDICINE >> NEWS
Scientists align billion-year-old protein with embryonic heart defects

University of Rochester scientists studying a vital protein called Serum Response Factor (SRF) in mice have learned new and unexpected facts about SRF's role in early cardiovascular development, and how a defect in this gene may be an underlying cause in human miscarriages.

The research is reported in this week's Proceedings of the National Academy of Sciences. At this point it is unclear whether subtle defects in SRF might also be linked to adult cardiovascular disease. However, the research provides a foundation for understanding how gene mutations may disrupt heart function, perhaps making some adults more susceptible to heart failure or irregular reactions to drugs.

"One reason for studying the biology of our genetic blueprint is so that we can understand how mutations in the genes encoding for proteins such as SRF may relate to human disease," says Joseph M. Miano, Ph.D., associate professor of Medicine in the Center for Cardiovascular Research at the University's Aab Institute of Biomedical Sciences. "Defining the full spectrum of genetic mutations is key to genetic screening and gene-based therapies."

SRF is one of nature's oldest proteins and is essential for life because it supports the basic internal structure of all living cells. Its function is to carefully turn on 300 of our 30,000 genes. But until now, scientists did not know much about its role in the heart region.

Miano's laboratory led a collaborative study of SRF with investigators from the Medical College of Wisconsin and Johns Hopkins University School of Medicine. They studied mouse embryos, using genetic trickery to nullify SRF in heart cells and key blood vessel cells called smooth muscle cells. They compared the mutant mice to those with a normal amount of SRF in the heart and blood vessels. The heart and related vessels did not develop properly in the mice without SRF, the team discovered.

In fact, while analyzing the heart cells under a hi
'"/>

Contact: Leslie Orr
leslie_orr@urmc.rochester.edu
585-275-5774
University of Rochester Medical Center
8-Dec-2004


Page: 1 2 3

Related medicine news :

1. Scientists replicate hepatitis C virus in laboratory
2. Scientists identify brain regions that decide where we look
3. Scientists uncover new mechanism for the amygdala in fear recognition
4. Scientists identify protein critical to melanoma growth
5. Scientists discover recipe for life: eating the Polymeal cuts heart disease by 76%
6. Scientists study fish oil diet in bid to cut heart attack risks
7. Scientists discover enzyme crucial to the transportation of proteins within cells
8. Scientists turn on the gender lens on cardiovascular disease research
9. Scientists stalk PPAR-gamma, find novel cancer connection
10. Scientists pinpoint flaw, offer new promise for stroke treatment
11. Scientists discover enzyme crucial to HIV replication

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/8/2019)... ... October 08, 2019 , ... ... in live samples, Meiqing Shi, associate professor with the University of Maryland Department ... latest paper published in Nature Communications, Shi and his lab have discovered a ...
(Date:10/8/2019)... ... October 08, 2019 , ... At ... 4medica® President Gregg Church will inform conference attendees how the ... orders management-by starting with the right, clean patient data. The single platform interfaces ...
(Date:10/8/2019)... Ark. (PRWEB) , ... October 08, 2019 , ... ... has selected CardioWise, Inc. a Digital Health Awards 1st Round (Top ... UCSF Digital Health Awards was to select companies that promote faster, better, more ...
(Date:10/8/2019)... ... ... husband and wife dental team, Dr.’s Michael and Azita Mansouri, will open their Marietta practice ... that Mansouri Family Dental Care & Associates has held the event to support ... great turnout, serving over 300 people in a single day in the past. Doors will ...
(Date:10/8/2019)... ... October 08, 2019 , ... U.S. ... Texas, that exclusively serves premier oral and maxillofacial surgeons – has formed a ... surgery practice with two locations near Knoxville, Tennessee. The partnership is USOSM’s first ...
Breaking Medicine News(10 mins):
(Date:10/15/2019)... Calif. (PRWEB) , ... October 14, 2019 , ... An ... to the mounting evidence suggesting a correlation between tooth loss and heart disease. The ... teeth had a 28 percent chance of also having heart-related problems, compared to just ...
(Date:10/11/2019)... N.Y. (PRWEB) , ... October 11, 2019 , ... ... — the regulated cannabis industry’s national resource — held the grand opening for ... New York, STOA Wellness offers a thoughtfully curated lineup of CBD wellness products ...
(Date:10/10/2019)... , ... October 10, 2019 , ... Smile Brands Inc. ... Misono in Natomas, California and opening of a new A+ location in Natomas. , ... locations across the Sacramento area. The group’s 14 general dentists and three specialists work ...
Breaking Medicine Technology:
Cached News: