HOME >> MEDICINE >> NEWS
Scientists discover enzyme crucial to HIV replication

Scientists have discovered that a cellular enzyme helps ferry HIV genetic instructions out of the cell nucleus where they can then be translated into proteins to begin their most destructive work. The cellular enzyme represents a potential new target for developing improved HIV drugs, say the researchers from the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health, and the McGill University AIDS Center.

Kuan-Teh Jeang, M.D., Ph.D., of NIAID led the research team reporting their discovery in the Oct. 29 issue of Cell.

"This finding provides new insights into a crucial step in HIV replication," says Anthony S. Fauci, M.D., director of NIAID. "The discovery also provides an attractive target for drug development which, if successful, might in time give us a completely new type of HIV drug that circumvents the problem of drug resistance."

Dr. Jeang's team found evidence that the virus co-opts an enzyme produced by human cells to transport HIV's genetic material out of the cell nucleus. Once out of the nucleus, these messenger RNAs begin directing the cell to create and assemble new virus particles.

The process of how HIV genetic material--a long unedited strand of RNA--exits the cell nucleus has long puzzled scientists. Human cells cut, edit and splice RNA before it can leave the nucleus, but somehow HIV subverts that process and exports from the nucleus the long version of RNA that encodes instructions for making new viral particles.

Scientists knew that HIV makes a protein called Rev to help skirt the prohibition on transporting the lengthy, unedited version of RNA from the nucleus. They also knew that HIV commandeers a human protein known as CRM1 to aid in this process. Rev and CRM1 together, however, are insufficient to explain how HIV flouts the molecular machinery that cuts and splices RNA before it leaves the nucleus.

"Unspliced RNA is like an unwieldy ball of yar
'"/>

Contact: Linda Joy
ljoy@niaid.nih.gov
301-402-1663
NIH/National Institute of Allergy and Infectious Diseases
29-Oct-2004


Page: 1 2

Related medicine news :

1. Scientists replicate hepatitis C virus in laboratory
2. Scientists identify brain regions that decide where we look
3. Scientists uncover new mechanism for the amygdala in fear recognition
4. Scientists identify protein critical to melanoma growth
5. Scientists discover recipe for life: eating the Polymeal cuts heart disease by 76%
6. Scientists study fish oil diet in bid to cut heart attack risks
7. Scientists discover enzyme crucial to the transportation of proteins within cells
8. Scientists turn on the gender lens on cardiovascular disease research
9. Scientists stalk PPAR-gamma, find novel cancer connection
10. Scientists align billion-year-old protein with embryonic heart defects
11. Scientists pinpoint flaw, offer new promise for stroke treatment

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/18/2019)... ... , ... HR Maximizer Inc ( https://hrmaximizer.com ) announced today ... Healthcare HR Association (HHHRA - https://hhhra.org ). In addition to having ... PageUp, CRC, Alliance Work Partners and Kognito. , Houston Healthcare HR Association, The ...
(Date:6/16/2019)... , ... June 15, 2019 , ... Convoy of Hope ... has been committed to helping those in need around the world. To date, Convoy ... than 125 countries. Convoy’s work would not be possible without the dedication and generosity ...
(Date:6/13/2019)... DETROIT (PRWEB) , ... June 13, 2019 , ... Endometriosis is a painful, inflammatory disease ... , Painful periods , Heavy bleeding , ... Constipation , Women’s Excellence uses the latest and newest treatment protocols in ...
(Date:6/13/2019)... ... June 13, 2019 , ... Pure Ratios, the ... cannabis delivery company, Driven Deliveries, Inc., the only publicly traded cannabis delivery service ... the population of California with overnight cannabis delivery to major thriving markets such ...
(Date:6/13/2019)... (PRWEB) , ... June 13, 2019 , ... Clinical ... experience, is pleased to announce that Jonathan Andrus , chief business officer at ... by the Duke-Margolis Center for Health Policy on July 1, 2019, in ...
Breaking Medicine News(10 mins):
(Date:6/14/2019)... (PRWEB) , ... June 14, 2019 , ... ... National Cyclotron and PET Centre, Chulabhorn Hospital announced today a research collaboration to ... of aging Thai individuals. The first subjects have been recruited and imaged. LMI ...
(Date:6/13/2019)... (PRWEB) , ... June 13, 2019 , ... ... as a Prime awardee of the Network of Quality Improvement and Innovation Contractor. ... five years. As a Prime NQIIC awardee partnering with other Quality Improvement ...
(Date:6/13/2019)... ... June 13, 2019 , ... ... has announced the new Smart Scheduling product, part of the HCHB Intelligence Suite, ... Scheduling product uses complex algorithms to create highly efficient routing, mapping and scheduling ...
Breaking Medicine Technology:
Cached News: