HOME >> MEDICINE >> NEWS
Scientists discover enzyme crucial to the transportation of proteins within cells

VANCOUVER, B.C. - December 16, 2004: Scientists at the University of British Columbia have discovered an enzyme in mammals crucial to the transportation of proteins within cells. Published today in Neuron, this discovery opens new avenues of understanding of the mechanisms underlying neuronal function and new therapeutic approaches for neurodegenerative diseases such as Alzheimers and Huntington Disease.

The enzyme, HIP14, is a palmitoyl transferase that adds signaling molecules to proteins resulting in their transportation to specific cellular locations where they perform essential functions. This process known as palmitoylation is extremely important for the normal functioning of the nervous system where proteins are transported rapidly within nerve cells known as neurons.

Until now, scientists did not know how mammalian proteins become palmitoylated. During their study of Huntington Disease, Dr. Michael Hayden's team at the Centre for Molecular Medicine and Therapeutics had previously identified a protein called HIP14 and recognized that it might play a role in palmitoylation. To further understand this mechanism, the Hayden team formed a partnership with Dr. Alaa El-Husseini and his team at the Brain Research Centre who are experts in the field of protein palmitoylation. Through this unique collaboration between experts in complementary fields, they discovered that HIP14 is indeed a mammalian palmitoyl transferase.

The teams also discovered that in the absence of the HIP14 enzyme, proteins were not transported to locations in the cell where they are needed. This change in protein trafficking is thought to result in severe neuronal dysfunction and may be a mechanism underlying diseases such as Alzheimers and Huntington Disease.

This research was funded by the Michael Smith Foundation for Health Research, the Canadian Institute of Health Research and the High Q Foundation.


'"/>

Contact: Krista Johnston
kristaj@cmmt.ubc.ca
604-875-3881
University of British Columbia
16-Dec-2004


Page: 1

Related medicine news :

1. Scientists replicate hepatitis C virus in laboratory
2. Scientists identify brain regions that decide where we look
3. Scientists uncover new mechanism for the amygdala in fear recognition
4. Scientists identify protein critical to melanoma growth
5. Scientists discover recipe for life: eating the Polymeal cuts heart disease by 76%
6. Scientists study fish oil diet in bid to cut heart attack risks
7. Scientists turn on the gender lens on cardiovascular disease research
8. Scientists stalk PPAR-gamma, find novel cancer connection
9. Scientists align billion-year-old protein with embryonic heart defects
10. Scientists pinpoint flaw, offer new promise for stroke treatment
11. Scientists discover enzyme crucial to HIV replication

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/31/2020)... , ... August 31, 2020 , ... ... innovative higher-learning opportunities through high-quality, career-relevant, and affordable online education – is proud ... . , Among the first of its kind in the nation, the ...
(Date:8/31/2020)... ... August 31, 2020 , ... In an effort to ... is donating 10 percent of each hotel room booked with a special new ... Chicagoland & Northwest Indiana (RMHC-CNI) , effective immediately. Donations will be applied to ...
(Date:8/28/2020)... ... August 28, 2020 , ... ... CEO Craig Mandeville was named an Entrepreneur Of The Year® 2020 Florida Award ... entrepreneurial business leaders whose ambitions deliver innovation, growth and prosperity as they build ...
(Date:8/28/2020)... ... ... Integrated Viral Protection (IVP Air) today announced that the True ... Mobile Biodefense Indoor Air Protection System that is the first system designed and proven ... equipped with the filtration system on September 8th. , The IVP Air S1 ...
(Date:8/27/2020)... , ... August 27, 2020 , ... ... Sikara Medspa is a leading aesthetic and wellness retreat. The practice is centered ... surrounding areas of Las Vegas. , Designed to be a sanctuary for ...
Breaking Medicine News(10 mins):
(Date:8/27/2020)... ... August 27, 2020 , ... Bridge To A Cure Foundation announces the appointment ... and pediatric neuro-oncologist who serves on the Board of Directors at The Preston Robert ... Medical School. , Internationally recognized, Dr. Friedman is a widely published author of more ...
(Date:8/26/2020)... , ... August 26, 2020 , ... ... in-home air purification systems kill Coronavirus. While air purification technologies, including GreenTech Environmental’s ... SARS and even Ebola, no air purification system has published results of singular ...
(Date:8/26/2020)... YORK (PRWEB) , ... August 26, 2020 , ... ... nation’s largest non-profit organization devoted to funding innovative lymphoma research and serving the ... its 25th Anniversary with a special virtual LRF Gala and Charity Auction ...
Breaking Medicine Technology:
Cached News: