HOME >> MEDICINE >> NEWS
Scientists discover enzyme crucial to the transportation of proteins within cells

VANCOUVER, B.C. - December 16, 2004: Scientists at the University of British Columbia have discovered an enzyme in mammals crucial to the transportation of proteins within cells. Published today in Neuron, this discovery opens new avenues of understanding of the mechanisms underlying neuronal function and new therapeutic approaches for neurodegenerative diseases such as Alzheimers and Huntington Disease.

The enzyme, HIP14, is a palmitoyl transferase that adds signaling molecules to proteins resulting in their transportation to specific cellular locations where they perform essential functions. This process known as palmitoylation is extremely important for the normal functioning of the nervous system where proteins are transported rapidly within nerve cells known as neurons.

Until now, scientists did not know how mammalian proteins become palmitoylated. During their study of Huntington Disease, Dr. Michael Hayden's team at the Centre for Molecular Medicine and Therapeutics had previously identified a protein called HIP14 and recognized that it might play a role in palmitoylation. To further understand this mechanism, the Hayden team formed a partnership with Dr. Alaa El-Husseini and his team at the Brain Research Centre who are experts in the field of protein palmitoylation. Through this unique collaboration between experts in complementary fields, they discovered that HIP14 is indeed a mammalian palmitoyl transferase.

The teams also discovered that in the absence of the HIP14 enzyme, proteins were not transported to locations in the cell where they are needed. This change in protein trafficking is thought to result in severe neuronal dysfunction and may be a mechanism underlying diseases such as Alzheimers and Huntington Disease.

This research was funded by the Michael Smith Foundation for Health Research, the Canadian Institute of Health Research and the High Q Foundation.


'"/>

Contact: Krista Johnston
kristaj@cmmt.ubc.ca
604-875-3881
University of British Columbia
16-Dec-2004


Page: 1

Related medicine news :

1. Scientists replicate hepatitis C virus in laboratory
2. Scientists identify brain regions that decide where we look
3. Scientists uncover new mechanism for the amygdala in fear recognition
4. Scientists identify protein critical to melanoma growth
5. Scientists discover recipe for life: eating the Polymeal cuts heart disease by 76%
6. Scientists study fish oil diet in bid to cut heart attack risks
7. Scientists turn on the gender lens on cardiovascular disease research
8. Scientists stalk PPAR-gamma, find novel cancer connection
9. Scientists align billion-year-old protein with embryonic heart defects
10. Scientists pinpoint flaw, offer new promise for stroke treatment
11. Scientists discover enzyme crucial to HIV replication

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:11/14/2019)... ... November 14, 2019 , ... With Giving Tuesday on Dec. ... businesses and organizations about the benefits of supporting local hospitalized veterans throughout Maryland. ... millions of people to give, collaborate and celebrate generosity before the holidays, and ...
(Date:11/14/2019)... ... , ... EMulate Therapeutics, Inc., a clinical-stage therapeutic device company ... 5 poster presentations related to its medical devices for treating adult and pediatric ... Phoenix, beginning on November 20 . , Two posters will be ...
(Date:11/14/2019)... ... November 14, 2019 , ... ... Administration (FDA) has granted acceptance to file status of its application for the ... in the disease neurofibromatosis type one (NF1). The FDA’s acceptance of the application ...
(Date:11/12/2019)... ... , ... AI for preventable harm analytics leader Jvion today announced that Jvion ... the Potential of AI”, which provides a “tip of the spear” analysis of the ... enough clients to complete a full KLAS analysis, Jvion was featured as having “by ...
(Date:11/12/2019)... TORONTO (PRWEB) , ... November 12, 2019 , ... ... of a clinical study. With increasing site activation cycle times, extended contract negotiations ... study start-up is an area of clinical operations that’s ripe for improvement. Following ...
Breaking Medicine News(10 mins):
(Date:11/11/2019)... ... November 11, 2019 , ... Oak Street Health , a network of ... new centers in Greensboro and Charlotte, with an additional center in Charlotte under development. ... different model of care that emphasizes quality of care rather than quantity of services. ...
(Date:11/11/2019)... ... November 11, 2019 , ... ... mutual agreement to facilitate the coordination and implementation of joint projects for ... medicinal products. These undertakings will empower biomedical professionals to leverage their roles ...
(Date:11/11/2019)... (PRWEB) , ... November 10, 2019 , ... ... rebranding alongside a redesign of its website , which features over 600 ... from the brand's 35+ year commitment to providing high-quality health and wellness products, ...
Breaking Medicine Technology:
Cached News: