HOME >> MEDICINE >> NEWS
Scientists find HIV-blocking protein in monkeys

Scientists at the Dana-Farber Cancer Institute have identified a protein that blocks HIV replication in monkey cells. Humans have a similar protein, although it is not as effective at stopping HIV, say the researchers whose work is published in this week's issue of Nature. The team, headed by Joseph Sodroski, M.D., is supported by the NIH's National Institute of Allergy and Infectious Diseases (NIAID).

"Identification of this HIV-blocking factor opens new avenues for intervening in the early stage of HIV infection, before the virus can gain a toehold," says NIAID Director Anthony S. Fauci, M.D. "The discovery also gives us critical insights about viral uncoating, a little understood step in the viral lifecycle. Basic discoveries like this provide the scientific springboard to future improvements in therapies for HIV disease."

"Over the years," notes Dr. Sodroski, "we've learned quite a bit about how HIV enters cells. More recently, we've developed a picture of the late stages of the viral lifecycle, as it leaves the cell. However, the steps between virus entry and conversion of the viral RNA into DNA have been a black box." A key preparatory step is the removal, or uncoating, of the protective shell surrounding HIV's genetic material. This coat, called the capsid, must be removed before HIV can insert its genetic material into the host cell's DNA and begin to make copies of itself. (See http://www.niaid.nih.gov/newsroom/graphics/hiv1.jpg for a simplified diagram of HIV, including the capsid.)

The discovery of this host protein helps pry open the black box of uncoating. Called TRIM5-alpha, it is the first found to specifically target HIV's capsid. With the identification of a specific protein that powerfully inhibits viral uncoating, says Dr. Sodroski, comes the possibility of manipulating and enhancing its activity. For example, he notes, humans have a version of TRIM5-alpha. W
'"/>

Contact: Anne A. Oplinger
aoplinger@niaid.nih.gov
301-402-1663
NIH/National Institute of Allergy and Infectious Diseases
25-Feb-2004


Page: 1 2 3

Related medicine news :

1. Scientists replicate hepatitis C virus in laboratory
2. Scientists identify brain regions that decide where we look
3. Scientists uncover new mechanism for the amygdala in fear recognition
4. Scientists identify protein critical to melanoma growth
5. Scientists discover recipe for life: eating the Polymeal cuts heart disease by 76%
6. Scientists study fish oil diet in bid to cut heart attack risks
7. Scientists discover enzyme crucial to the transportation of proteins within cells
8. Scientists turn on the gender lens on cardiovascular disease research
9. Scientists stalk PPAR-gamma, find novel cancer connection
10. Scientists align billion-year-old protein with embryonic heart defects
11. Scientists pinpoint flaw, offer new promise for stroke treatment

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/31/2020)... NEW HAVEN, Conn. (PRWEB) , ... August 31, ... ... a medical device intended to improve outcomes for patients with advanced heart failure, ... Innovation Research (SBIR) grant in the amount of $555,358 from the National Heart, ...
(Date:8/28/2020)... ... August 28, 2020 , ... ... CEO Craig Mandeville was named an Entrepreneur Of The Year® 2020 Florida Award ... entrepreneurial business leaders whose ambitions deliver innovation, growth and prosperity as they build ...
(Date:8/28/2020)... ... August 28, 2020 , ... The 15 scholarships being offered ... & Wellness mobile app and web-portal. NCPCV received a 2020 grant from Motorola ... each year to organizations, such as Destination Imagination, which support and advance public ...
(Date:8/28/2020)... MIAMI (PRWEB) , ... August 28, 2020 , ... ... in Miami is the first Florida school to deploy its breakthrough Mobile Biodefense Indoor ... destroy airborne COVID-19. True North Classical Academy plans to fully reopen equipped with the ...
(Date:8/28/2020)... ... August 28, 2020 , ... A July 27 ... obese individuals are at an increased risk of developing severe COVID-19 symptoms. The ... COVID-19; however, because the same organ systems that the coronavirus attacks are already ...
Breaking Medicine News(10 mins):
(Date:8/31/2020)... ... 31, 2020 , ... Continuing on its rapid national expansion ... and deodorization provider - is proud to announce it has opened doors in ... and residents throughout the area. , Germinator provides a 100% safe and non-toxic ...
(Date:8/28/2020)... ... August 28, 2020 , ... ... care medical centers in Florida and San Antonio is happy to announce that ... medical centers. , In this capacity he will serve as community advisor, advertising ...
(Date:8/28/2020)... ... 28, 2020 , ... Dr. Raheleh Sarbaziha has been reimagining ... approach. Armed with her qualifications from Ross University School of Medicine and the ... human body with the nation and world. With a fellowship in Integrative Medicine ...
Breaking Medicine Technology:
Cached News: