HOME >> MEDICINE >> NEWS
Scientists find biological key to 'wasting syndrome'

SAN DIEGO Department of Veterans Affairs (VA) researchers and colleagues have discovered a biochemical mechanism that may explain wasting syndrome, a condition that causes severe weight loss and weakness in patients with chronic inflammatory diseases and often hastens their death.

The findings, published in the December 3 issue of the European Molecular Biology Organization Journal, may lead to new drugs to ease the debilitating effects of cancer, AIDS, and other serious degenerative illnesses.

Scientists in San Diego pinpointed the biological chain of events that caused wasting in mice, then identified the same process in liver tissue from cancer patients.

They said the striking similarity between the condition in mice and humans will expedite the development of new treatments.

"When we saw that it was virtually identical in animals and humans, we were ecstatic," said the studys senior author, Mario Chojkier, M.D., of the VA San Diego Healthcare System and the University of California, San Diego (UCSD).

"What weve described in animals has much greater relevance than we ever thought to human wasting syndrome. Were optimistic this will bring hope and relief very quickly to the bedside."

Dr. Chojkier and lead author Martina Buck, Ph.D., of VA, UCSD and the Salk Institute for Biological Studies, described the steps by which tumor necrosis factor (TNF) alpha, an immune-system protein, prevents the production of albumin. Low levels of albumin, a critical protein made in the liver, is a keynote of wasting.

TNF-alpha and low albumin had for years been implicated in wasting, but the connection between the two was a mystery. Drs. Buck and Chojkier showed that TNF alpha causes oxidative stress in the liver cell and boosts the production of the free-radical gas nitric oxide. It also causes the addition of a phosphorous molecule to a protein called C/EBP beta, which normally joins DNA in the nucleus of the
'"/>

Contact: Cindy Butler
cynthia.butler@med.va.gov
858-552-8585 x7821
VA Research Communications Service
2-Dec-2001


Page: 1 2 3

Related medicine news :

1. Scientists replicate hepatitis C virus in laboratory
2. Scientists identify brain regions that decide where we look
3. Scientists uncover new mechanism for the amygdala in fear recognition
4. Scientists identify protein critical to melanoma growth
5. Scientists discover recipe for life: eating the Polymeal cuts heart disease by 76%
6. Scientists study fish oil diet in bid to cut heart attack risks
7. Scientists discover enzyme crucial to the transportation of proteins within cells
8. Scientists turn on the gender lens on cardiovascular disease research
9. Scientists stalk PPAR-gamma, find novel cancer connection
10. Scientists align billion-year-old protein with embryonic heart defects
11. Scientists pinpoint flaw, offer new promise for stroke treatment

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/12/2019)... ... 2019 , ... Remote Medical Technologies (RMT) will be a ... Annual Meeting being held in National Harbor, Maryland on March 18th to the ... RMT’s Mobile-Cart Solution . These solutions are high-performance HD telepathology systems ...
(Date:3/12/2019)... ... 12, 2019 , ... Caring Transitions is pleased to recognize Caring Transitions North ... owned by mother/daughter team Donna and Nicole Rea with the support of their team. ... Donna and Nicole of Caring Transitions of North Dallas Suburbs drove them to be ...
(Date:3/12/2019)... ... March 12, 2019 , ... When it comes to selecting ... to treat pain and diseases of joints, muscles, tendons and ligaments, “choose wisely,” ... the movie Indiana Jones. , “Some clinics and health centers have been built ...
(Date:3/12/2019)... , ... March 12, 2019 , ... A recent report ... facilities. Focusing on a series of Idaho case studies, the report argues that charter ... These arguments, while focused on Idaho in this particular report, have been made with ...
(Date:3/12/2019)... ... March 12, 2019 , ... The U.S. healthcare industry has ... each patient moving through different care settings. With a shared goal of providing ... ® today announced its support for broader discussions about the unique patient identifier ...
Breaking Medicine News(10 mins):
(Date:3/16/2019)... Hartford, CT (PRWEB) , ... March 16, 2019 , ... ... Ryaz Ansari are proud to announce that they are launching the JawFixers Implant Synergy ... March 27, 2019. This series is designed for implant clinicians to better understand the ...
(Date:3/15/2019)... , ... March 15, 2019 , ... Peter Saltonstall ... will be the keynote speaker at Keck Graduate Institute’s 18th annual commencement ceremony on ... CEO in 2008 after he served for more than 30 years as a senior ...
(Date:3/14/2019)... WARNER ROBINS, Ga. (PRWEB) , ... March 14, ... ... small minority-owned business enterprise (MBE) LOUi Consulting Group, Inc. (LCGI) its fourth consecutive ... DHA has awarded LCGI a $7M, 22-month contract to maintain the computer servers ...
Breaking Medicine Technology:
Cached News: