HOME >> MEDICINE >> NEWS
Scientists find biological key to 'wasting syndrome'

SAN DIEGO Department of Veterans Affairs (VA) researchers and colleagues have discovered a biochemical mechanism that may explain wasting syndrome, a condition that causes severe weight loss and weakness in patients with chronic inflammatory diseases and often hastens their death.

The findings, published in the December 3 issue of the European Molecular Biology Organization Journal, may lead to new drugs to ease the debilitating effects of cancer, AIDS, and other serious degenerative illnesses.

Scientists in San Diego pinpointed the biological chain of events that caused wasting in mice, then identified the same process in liver tissue from cancer patients.

They said the striking similarity between the condition in mice and humans will expedite the development of new treatments.

"When we saw that it was virtually identical in animals and humans, we were ecstatic," said the studys senior author, Mario Chojkier, M.D., of the VA San Diego Healthcare System and the University of California, San Diego (UCSD).

"What weve described in animals has much greater relevance than we ever thought to human wasting syndrome. Were optimistic this will bring hope and relief very quickly to the bedside."

Dr. Chojkier and lead author Martina Buck, Ph.D., of VA, UCSD and the Salk Institute for Biological Studies, described the steps by which tumor necrosis factor (TNF) alpha, an immune-system protein, prevents the production of albumin. Low levels of albumin, a critical protein made in the liver, is a keynote of wasting.

TNF-alpha and low albumin had for years been implicated in wasting, but the connection between the two was a mystery. Drs. Buck and Chojkier showed that TNF alpha causes oxidative stress in the liver cell and boosts the production of the free-radical gas nitric oxide. It also causes the addition of a phosphorous molecule to a protein called C/EBP beta, which normally joins DNA in the nucleus of the
'"/>

Contact: Cindy Butler
cynthia.butler@med.va.gov
858-552-8585 x7821
VA Research Communications Service
2-Dec-2001


Page: 1 2 3

Related medicine news :

1. Scientists replicate hepatitis C virus in laboratory
2. Scientists identify brain regions that decide where we look
3. Scientists uncover new mechanism for the amygdala in fear recognition
4. Scientists identify protein critical to melanoma growth
5. Scientists discover recipe for life: eating the Polymeal cuts heart disease by 76%
6. Scientists study fish oil diet in bid to cut heart attack risks
7. Scientists discover enzyme crucial to the transportation of proteins within cells
8. Scientists turn on the gender lens on cardiovascular disease research
9. Scientists stalk PPAR-gamma, find novel cancer connection
10. Scientists align billion-year-old protein with embryonic heart defects
11. Scientists pinpoint flaw, offer new promise for stroke treatment

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:9/11/2019)... ... September 11, 2019 , ... Workplace injuries cost individuals, organisations ... injury risks which lead to musculoskeletal disorders (MSDs). , Starting with the ... team at Soter Analytics helps avoid ergonomic injury by coaching workers ...
(Date:9/11/2019)... ... September 11, 2019 , ... ... September 11-14 in Minneapolis at the Mall of America Radisson Blu. Four experts ... faculty members for the high-profile, knee-focused conference, which brings together more than 100 ...
(Date:9/11/2019)... GULF BREEZE, Fla. (PRWEB) , ... September 11, 2019 , ... ... what has caused damage or injury to the body. , Methamphetamine permanently harms the ... it. Through autopsies, doctors are getting a better understanding of how the damage occurs. ...
(Date:9/11/2019)... Calif. (PRWEB) , ... September 11, 2019 , ... Executives ... and magnitude of change in the healthcare industry over the past several years has ... a lot worse. The future of healthcare in America will depend largely on how ...
(Date:9/11/2019)... ... 10, 2019 , ... Four Shriners for Children Medical Center ... recognized among the best doctors in the San Gabriel Valley for providing high-quality, ... H. Cho, M.D. – Chief of Staff, scoliosis, spinal deformity surgery, limb deformity, ...
Breaking Medicine News(10 mins):
(Date:9/14/2019)... YORK (PRWEB) , ... September 13, 2019 , ... ... were allegedly sexually abused by Dr. Reginald Archibald over at least 3 ... lawsuits, including Poppel v. Rockefeller (United States District Court - Southern District of New ...
(Date:9/14/2019)... ... September 13, 2019 , ... St. Joseph’s ... to celebrate the structural topping out of the St. Joseph’s Hospital patient tower ... include a new six-story patient tower that will house a two-story lobby, waiting ...
(Date:9/12/2019)... ... September 12, 2019 , ... Stratosphere Networks will sponsor ... take place on Monday, October 7 at Found Kitchen and Social House in Evanston ... research on GRIN2B-Related Neurodevelopmental Disorder. GRIN2B is a gene on the short arm of ...
Breaking Medicine Technology:
Cached News: