HOME >> MEDICINE >> NEWS
Scientists find protein in Epstein-Barr virus causes B cell lymphoma in laboratory mice

CHAPEL HILL - Scientists at the University of North Carolina at Chapel Hill, working with colleagues in Japan, have proven that a protein called latent membrane protein 1 in Epstein-Barr virus causes a form of cancer known as B cell lymphoma in mice.

The work is important, the scientists say, because it shows the protein's central role in Epstein-Barr virus' ability to change normal cells into cancerous ones. That virus already is known to cause infectious mononucleosis in humans and has been associated with such malignancies as Burkett's lymphoma, Hodgkin's lymphoma and nose and throat cancer. It is especially hazardous to AIDS patients and other patients whose immune systems have weakened.

"We have shown for the first time that Epstein-Barr virus clearly can cause cancer," said Dr. Nancy Raab-Traub, professor of microbiology at the UNC-CH School of Medicine and a member of the UNC Lineberger Comprehensive Cancer Center. "Now we can go after the specific protein that is responsible and perhaps one day stop that protein function and prevent the cancer from growing."

The first report on the continuing research appeared in the Proceedings of the National Academy of Sciences last year, and a second describing additional findings is being published in Friday's (Oct. 8) issue of the journal Science.

In the Proceedings paper, Raab-Traub and her colleagues described breeding three different lines of laboratory mice into which the latent membrane protein 1 (LMP1) from Epstein-Barr virus was genetically incorporated. Lymphoma developed in all three strains of mice, which are known as transgenic mice, and had affected 42 percent of the animals within 18 months.

Investigators detected the protein in high concentrations in cancerous tissue, but only in trace amounts in normal lymph system tissues.

"This work demonstrated that LMP1 alone -- without expression of other Epstein-Barr virus genes -- causes
'"/>

Contact: David Williamson
David_Williamson@unc.edu
919-962-8596
University of North Carolina at Chapel Hill
7-Oct-1999


Page: 1 2

Related medicine news :

1. Scientists replicate hepatitis C virus in laboratory
2. Scientists identify brain regions that decide where we look
3. Scientists uncover new mechanism for the amygdala in fear recognition
4. Scientists identify protein critical to melanoma growth
5. Scientists discover recipe for life: eating the Polymeal cuts heart disease by 76%
6. Scientists study fish oil diet in bid to cut heart attack risks
7. Scientists discover enzyme crucial to the transportation of proteins within cells
8. Scientists turn on the gender lens on cardiovascular disease research
9. Scientists stalk PPAR-gamma, find novel cancer connection
10. Scientists align billion-year-old protein with embryonic heart defects
11. Scientists pinpoint flaw, offer new promise for stroke treatment

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/31/2020)... ... August 31, 2020 , ... Ocean Springs, ... masks to medical first responders across the United States. Since the start of ... protective equipment (PPE) medical centers , hospitals , firefighters , ...
(Date:8/31/2020)... ... August 31, 2020 , ... Smile Brands ... groups in the United States, today announced the grand opening of another affiliated ... , Patients will enjoy convenient hours, a comfortable office, and full-service care at ...
(Date:8/31/2020)... (PRWEB) , ... August 31, 2020 , ... ... experience working, both directly with persons with autism and other developmental disabilities, as ... includes early intervention, parent education, adolescents with autism, school consultation, and staff development. ...
(Date:8/28/2020)... Ariz. (PRWEB) , ... August 28, 2020 , ... ... respiratory assist system designed to help treat patients with respiratory conditions, including COVID-19, ... mixture of helium and oxygen, but it captures exhaled gas and scrubs it ...
(Date:8/28/2020)... ... August 28, 2020 , ... Ziegler, a specialty ... its investment in Synchronous Health, a tech-enabled behavioral health and well-being solutions provider. ... human empathy with artificial intelligence (AI) to increase access and quality of behavioral ...
Breaking Medicine News(10 mins):
(Date:8/26/2020)... WALHALLA, N.D. (PRWEB) , ... August 26, 2020 , ... ... too familiar with the daily routine for preventing the Coronavirus. Wear a mask, keep ... author and fiber advocate Dr. Denis Burkitt said it best in 1977, “How much ...
(Date:8/26/2020)... ... 26, 2020 , ... Hero Life Sciences announced today that it ... ply surgical disposable face masks and N95 respirators in its manufacturing plant located in ... that most Americans are facing in trying to find quality disposable face masks during ...
(Date:8/26/2020)... , ... August 26, 2020 , ... ... the appointment of Claude E. Hooton as President and Chief Executive Officer effective ... Executive Chairman of the company’s Board of Managers. , Mr. Hooton, a ...
Breaking Medicine Technology:
Cached News: