Scientists identify key mechanism in estrogen's role in preventing bone loss

Scientists have uncovered a significant new link in the chain of immune system events through which estrogen prevents bone loss and that contribute to bone loss when estrogen is deficient. Through research in mice, the scientists discovered that an immune signaling molecule called type b transforming growth factor (TGFb) is responsible for a cascade of events that leads estrogen to prevent bone loss. When TGFb signaling in T cells is blocked, the bone-sparing effects of estrogen are lost. The findings could lead to new therapeutic approaches for preventing bone loss. Results of the research were published online in the Proceedings of the National Academy of Sciences the week of October 25.

The study's senior author was Roberto Pacifici, MD, Herndon professor of medicine and director of the Division of Endocrinology at Emory University School of Medicine. Lead author was Emory research associate Yuhao Gao, PhD.

Previous research has shown that bone loss due to estrogen deficiency is caused by the overexpansion of immune T cells. T cells are known to produce a protein called tumor necrosis factor (TNF), which increases the formation of osteoclasts in rodents and humans. Osteoclasts are cells that help cause the absorption and removal of bone.

In research published in PNAS in August 2003, Dr. Pacifici and his colleagues demonstrated that estrogen deficiency leads to the expression of the immune regulatory protein interferon gamma (IFN-g), which in turn stimulates a protein called class II transactivator (CIITA). They found that increased expression of CIITA leads to expanded antigen presentation by macrophages (immune cells that alert T cells to the presence of invading organisms) and in turn to enhanced T cell activation in the bone marrow and extended T-cell lifespan.

The investigators' new research traces another step in the "upstream" pathway leading to estrogen's effect on bone. In order to model postmenopausal estroge

Contact: Holly Korschun
Emory University Health Sciences Center

Page: 1 2

Related medicine news :

1. Scientists replicate hepatitis C virus in laboratory
2. Scientists identify brain regions that decide where we look
3. Scientists uncover new mechanism for the amygdala in fear recognition
4. Scientists identify protein critical to melanoma growth
5. Scientists discover recipe for life: eating the Polymeal cuts heart disease by 76%
6. Scientists study fish oil diet in bid to cut heart attack risks
7. Scientists discover enzyme crucial to the transportation of proteins within cells
8. Scientists turn on the gender lens on cardiovascular disease research
9. Scientists stalk PPAR-gamma, find novel cancer connection
10. Scientists align billion-year-old protein with embryonic heart defects
11. Scientists pinpoint flaw, offer new promise for stroke treatment

Post Your Comments:

(Date:6/24/2016)... PASADENA, CA (PRWEB) , ... June 24, 2016 , ... Marcy was in a crisis. ... he would lash out at his family verbally and physically. , “When something upset him, ... table, he would use it. He would throw rocks at my other children and say ...
(Date:6/24/2016)... (PRWEB) , ... June 24, 2016 , ... ... now offering micro-osteoperforation for accelerated orthodontic treatment. Dr. Cheng has extensive experience with ... Damon brackets , AcceleDent, and accelerated osteogenic orthodontics. , Micro-osteoperforation is a ...
(Date:6/24/2016)... ... 24, 2016 , ... People across the U.S. are sharpening their pencils and ... essay contest in which patients and their families pay tribute to a genetic counselor ... National Society of Genetic Counselors (NSGC) Annual Education Conference (AEC) this September. , ...
(Date:6/24/2016)... ... June 24, 2016 , ... Puradigm® & Innovative Solutions today ... cultivation and processing operations at its production facility, and opened its first two ... the manufacturer of a complete system of proactive air and surface purification solutions ...
(Date:6/24/2016)... ... June 24, 2016 , ... Venture Construction Group ... Tournament held on June 20th at the Woodmont Country Club at 1201 Rockville ... an organization dedicated to helping service members that have been wounded in battle and ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... , Belgium , June 24, ... VNRX), today announced the appointment of Dr. ... Directors as a Non-Executive Director, effective June 23, ... Audit, Compensation and Nominations and Governance Committees.  As ... Futcher will provide independent expertise and strategic counsel ...
(Date:6/23/2016)... Research and Markets has announced the addition of ... report to their offering. ... kidney failure, it replaces the function of kidneys by removing ... thus the treatment helps to keep the patient body,s electrolytes ... Increasing number of ESRD patients & substantial healthcare expenditure ...
(Date:6/23/2016)... a startling report released today, National Safety Council research ... proven plan to eliminate prescription opioid overdoses. Prescription Nation ... tackling the worst drug crisis in recorded U.S. history, assigned a ... , New Mexico , Tennessee ... failing states, three – Michigan , ...
Breaking Medicine Technology:
Cached News: