HOME >> MEDICINE >> NEWS
Scientists identify key mechanism in estrogen's role in preventing bone loss

Scientists have uncovered a significant new link in the chain of immune system events through which estrogen prevents bone loss and that contribute to bone loss when estrogen is deficient. Through research in mice, the scientists discovered that an immune signaling molecule called type b transforming growth factor (TGFb) is responsible for a cascade of events that leads estrogen to prevent bone loss. When TGFb signaling in T cells is blocked, the bone-sparing effects of estrogen are lost. The findings could lead to new therapeutic approaches for preventing bone loss. Results of the research were published online in the Proceedings of the National Academy of Sciences the week of October 25.

The study's senior author was Roberto Pacifici, MD, Herndon professor of medicine and director of the Division of Endocrinology at Emory University School of Medicine. Lead author was Emory research associate Yuhao Gao, PhD.

Previous research has shown that bone loss due to estrogen deficiency is caused by the overexpansion of immune T cells. T cells are known to produce a protein called tumor necrosis factor (TNF), which increases the formation of osteoclasts in rodents and humans. Osteoclasts are cells that help cause the absorption and removal of bone.

In research published in PNAS in August 2003, Dr. Pacifici and his colleagues demonstrated that estrogen deficiency leads to the expression of the immune regulatory protein interferon gamma (IFN-g), which in turn stimulates a protein called class II transactivator (CIITA). They found that increased expression of CIITA leads to expanded antigen presentation by macrophages (immune cells that alert T cells to the presence of invading organisms) and in turn to enhanced T cell activation in the bone marrow and extended T-cell lifespan.

The investigators' new research traces another step in the "upstream" pathway leading to estrogen's effect on bone. In order to model postmenopausal estroge
'"/>

Contact: Holly Korschun
hkorsch@emory.edu
404-727-3990
Emory University Health Sciences Center
28-Oct-2004


Page: 1 2

Related medicine news :

1. Scientists replicate hepatitis C virus in laboratory
2. Scientists identify brain regions that decide where we look
3. Scientists uncover new mechanism for the amygdala in fear recognition
4. Scientists identify protein critical to melanoma growth
5. Scientists discover recipe for life: eating the Polymeal cuts heart disease by 76%
6. Scientists study fish oil diet in bid to cut heart attack risks
7. Scientists discover enzyme crucial to the transportation of proteins within cells
8. Scientists turn on the gender lens on cardiovascular disease research
9. Scientists stalk PPAR-gamma, find novel cancer connection
10. Scientists align billion-year-old protein with embryonic heart defects
11. Scientists pinpoint flaw, offer new promise for stroke treatment

Post Your Comments:
(Date:11/22/2014)... 22, 2014 The topic of B&D ... block retaining walls. The article states that, “While they give ... necessary steps that go into creating this powerful look.” , ... retaining wall is choosing which kind of block matches your ... B&D Rockeries says, “The two main options are concrete and ...
(Date:11/22/2014)... Forbes Living TV and ... announce that Ashley Lombardo and friend Candy Sherman are ... Ms. Lombardo entered friend Candy Sherman to receive a ... how her friend is courageously battling lung cancer and ... Despite medical bills piling up and the constant struggle ...
(Date:11/22/2014)... “Greenfield Naturals” was featured on NewsWatch as ... features the latest and coolest technology products available to ... NewsWatch, conducted the product review and shared with viewers ... water. , From pollution to hazardous substances in water, ... done to remove these chemicals, especially in water. , ...
(Date:11/22/2014)... 2014 (HealthDay News) -- Those air-blown hand dryers in ... paper towels, a new study suggests. British researchers ... of volunteers in order to simulate poorly washed hands. ... dryers or paper towels to dry their hands. ... amounts of germs around both types of dryers than ...
(Date:11/21/2014)... November 21, 2014 Porcelain veneer ... smiles for patients in preparation for the coming holiday ... fronts of teeth, look completely natural, and can be ... veneers are also valued for their ability to strengthen ... can be used on one or several teeth to ...
Breaking Medicine News(10 mins):Health News:5 Step Installment of Block Retaining Walls is Topic of Latest Article by B&D Rockeries 2Health News:Forbes Living TV Announces Winner of Thanksgiving #PayItForward Contest 2Health News:An Easy Home Solution to Get Better Tasting Water was Featured on NewsWatch Television on October 30, 2014 2Health News:Restroom Hand Dryers Spread More Germs Than Paper Towels, Study Finds 2Health News:Los Angeles Porcelain Veneers Dentist, Dr. Kevin Sands, Now Creates Picture-Perfect Smiles for Patients for the Holiday Season 2
(Date:11/21/2014)... 21. November 2014 ... bekannt gegeben, dass die Europäische Arzneimittel-Agentur ... Kennzeichnung als Orphan-Medizinprodukt an Palovarotene vergeben ... zur Behandlung von Fibrodysplasia ossificans progressiva ... beeinträchtigende genetische Krankheit, die von schmerzhaften, ...
(Date:11/21/2014)... -- Edwards Lifesciences Corporation (NYSE: EW ), the ... hemodynamic monitoring, announced today that it will increase its ... launch of Edwards Lifesciences Foundation,s new charitable initiative, ... communities where its employees live and work. ... $8 million, including more than $7 million in cash ...
(Date:11/21/2014)... Nov. 20, 2014  RedRick Technologies, a provider ... reading room environment guidance, has helped the new ... reading room, which may also serve as a ... Medicine. "In line with the ... of Radiology,s Imaging 3.0 ™ initiative, the ...
Breaking Medicine Technology:Clementia Pharmaceuticals erhält EMA-Kennzeichnung als Orphan-Medizin für Palovarotene zur Behandlung von Fibrodysplasia ossificans progressiva 2Clementia Pharmaceuticals erhält EMA-Kennzeichnung als Orphan-Medizin für Palovarotene zur Behandlung von Fibrodysplasia ossificans progressiva 3Edwards Lifesciences Increases Charitable Giving In 2014 To Support Launch Of Every Heartbeat Matters 2RedRick Technologies Helps Penn Radiology Implement New Radiology Reading Room Concepts 2RedRick Technologies Helps Penn Radiology Implement New Radiology Reading Room Concepts 3
Cached News: