HOME >> MEDICINE >> NEWS
Scientists identify new pathway of antidepressant action

Scientists at UC San Francisco have discovered a new chemical pathway in the brain by which the most common antidepressants may alter mood. The research demonstrates that many popular mood modulators trigger chemical activity along more than one track at a time. It shows too how a brain chemical, known as a neurosteroid, might make a prime target for drugs to improve severe mood swings.

The researchers are publishing their study in the November 9 issue of the Proceedings of the National Academy of Sciences (PNAS).

Antidepressants such as Prozac, Paxil and Zoloft are thought to relieve depression by increasing the availability of one of the body's natural mood-enhancing chemicals, the neurotransmitter serotonin. But the UCSF experimenters examined the effect of these same antidepressants on an entirely different chemical pathway -- one increasingly thought to play a role in mood regulation as well. It involves a natural brain compound called a neurosteroid, only recognized in the last 10 or 15 years.

The scientists discovered that all three of these antidepressants, known as SSRI's, not only affect serotonin availability, but also greatly increase the synthesis of a key neurosteroid -- 10 to 30-fold. The profound effect, they found, comes from the SSRI's ability to greatly boost the action of the final enzyme involved in the synthesis of the neurosteroid in the brain.

"Each of these three serotonin reuptake inhibitors, or SSRI's, shows a dramatic positive effect on the levels of allopregnanolone, a steroid made in the brain, which most likely modulates mood and plays a role in heightened anxiety and depression found in severe premenstrual disorders and other conditions," said Synthia Mellon, PhD, senior author on the PNAS study and a professor of reproductive endocrinology at UCSF.

"The study points to the likelihood that SSRI's control mood by more than the one pathway that has received most of our attention, and it suggests that the ster
'"/>

Contact: Wallace Ravven
wravven@pubaff.ucsf.edu
415-476-2557
University of California - San Francisco
8-Nov-1999


Page: 1 2 3

Related medicine news :

1. Scientists replicate hepatitis C virus in laboratory
2. Scientists identify brain regions that decide where we look
3. Scientists uncover new mechanism for the amygdala in fear recognition
4. Scientists identify protein critical to melanoma growth
5. Scientists discover recipe for life: eating the Polymeal cuts heart disease by 76%
6. Scientists study fish oil diet in bid to cut heart attack risks
7. Scientists discover enzyme crucial to the transportation of proteins within cells
8. Scientists turn on the gender lens on cardiovascular disease research
9. Scientists stalk PPAR-gamma, find novel cancer connection
10. Scientists align billion-year-old protein with embryonic heart defects
11. Scientists pinpoint flaw, offer new promise for stroke treatment

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Scientists identify new pathway antidepressant action

(Date:5/27/2015)... (PRWEB) May 27, 2015 NOVAtime ... of Workforce Management solutions for enterprise organizations, announced ... 5000 solution to automate its time, attendance and ... 9 locations in the United States. , ... award-winning supplier of 21 retail, private label, and ...
(Date:5/27/2015)... The MedSpa at Hendrick is excited to ... in Abilene, Texas: Xeomin®, Belotero Balance® and Radiesse®. , ... lines, better known as the lines between the eyebrows ... treat smoker’s lines around the mouth and marionette lines ... the appearance of smile lines or lines around the ...
(Date:5/27/2015)... Chicago, IL (PRWEB) May 27, 2015 ... River North-based advertising agency, will partner with LifeSource to ... community-focused event will take place in a LifeSource donor ... 9:00 a.m. to 4:00 p.m. , Demand for whole ... center in Illinois, during the summer months. LifeSource requires ...
(Date:5/27/2015)... CA (PRWEB) May 27, 2015 With ... total communication environment where the message is not only heard ... toy, drawing, or virtually any motivating image. This award-winning and ... to offer. , Now, using InnerVoice Sender app ... can be sent to a learner remotely for no additional ...
(Date:5/27/2015)... 27, 2015 A television program using ... and Roswell Park Cancer Institute winning ... award-winning story, Cancer Can’t Win , highlights the ... Cancer Institute. The production team followed five people who ... as they received treatment from doctors and medical experts ...
Breaking Medicine News(10 mins):Health News:SanMar Corporation Successfully Implemented NOVAtime Workforce Management Solution across 9 locations 2Health News:SanMar Corporation Successfully Implemented NOVAtime Workforce Management Solution across 9 locations 3Health News:The MedSpa at Hendrick Introduces Xeomin®, Belotero Balance® and Radiesse® Injectables 2Health News:Donate Your Break and Save Lives at the River North Blood Drive 2Health News:Newly Released: InnerVoice Sender App Ups the Ante in Communication Technology for Autism with Remote Prompting 2Health News:Newly Released: InnerVoice Sender App Ups the Ante in Communication Technology for Autism with Remote Prompting 3Health News:Newly Released: InnerVoice Sender App Ups the Ante in Communication Technology for Autism with Remote Prompting 4Health News:MediaSource Wins New York Emmy® Award as Premier Health Care Storytellers 2Health News:MediaSource Wins New York Emmy® Award as Premier Health Care Storytellers 3
(Date:5/27/2015)... Research and Markets( http://www.researchandmarkets.com/research/ljsxt8/asia_pacific ) has announced the addition of ... Growth, Trends And Forecasts (2014 - 2019)" company profile ... market for Portable X-Ray Devices is expected to ... X-Ray is a form of electromagnetic radiation which is ... The need of point of care diagnostics has led to ...
(Date:5/27/2015)... -- Doctors from the Sheikh Zayed Institute for ... System are the first in the ... benign but painful bone tumor that commonly occurs in ... high-intensity focused ultrasound (MR-HIFU) method. Two patients, 16-year-old ... have been treated successfully in a research study aimed ...
(Date:5/27/2015)... DUBLIN , May 25, 2015 ... addition of the "2015 Strategies in the ... offering. This comprehensive seven-country report contains ... help current suppliers and potential market entrants identify ... coagulation testing market during the next five years. ...
Breaking Medicine Technology:Asia Pacific Portable X Ray Devices Market 2015 - Trends And Forecasts to 2019 2Children's National first in US to destroy bone tumors with incisionless surgery 2Children's National first in US to destroy bone tumors with incisionless surgery 3Children's National first in US to destroy bone tumors with incisionless surgery 4Global Coagulation Testing Market Strategies 2015 2Global Coagulation Testing Market Strategies 2015 3
Cached News: