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Scientists identify novel enzyme with key role in leukemia protein's normal function

se1 can make good targets for cancer drugs and they can be inhibited with oral, relatively non-toxic compounds. Thus, a drug that blocks Taspase1 might shut down the runaway proliferation of blood cells that causes the leukemia - and might work in other cancers as well.

"We'd be very interested in making an inhibitor to Taspase1, which could knock the HOX genes out of action, and test whether cancers are addicted to their HOX genes," said Korsmeyer, who is the Sidney Farber Professor of Pathology at Harvard Medical School and a Howard Hughes Medical Institute investigator.

Gary Gilliland, MD, PhD, a leukemia specialist at Dana-Farber and Brigham and Women's Hospital, commented on the paper in an accompanying editorial. Further research to follow up this new lead, he wrote, "should provide further insight into the potential therapeutic value of Taspase inhibitors in treatment of leukemia associated with MLL gene rearrangements." The research was supported in part by grants from the National Institutes of Health.


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Contact: Bill Schaller
william_schaller@dfci.harvard.edu
617-632-5357
Dana-Farber Cancer Institute
31-Oct-2003


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