HOME >> MEDICINE >> NEWS
Scientists identify protein critical to melanoma growth

BOSTON--Researchers at Dana-Farber Cancer Institute and Children's Hospital Boston have discovered that malignant melanoma, the potentially lethal skin cancer, can't grow without a steady supply of a protein that normal cells can do without.

The findings, which are published in the December issue of Cancer Cell, suggest that drugs that cut off melanoma cells' supply of the protein, called CDK2, might curb the growth of the dangerous skin cancer in patients, and with relatively low toxicity.

In theory, such a drug would leave normal cells unharmed and have many fewer side effects compared to standard chemotherapy.

Working with melanoma cells grown in the laboratory, the researchers, led by David E. Fisher, MD, PhD, Director of the Melanoma Program at Dana-Farber and the paper's senior author, showed that adding a chemical that quashed the activity of CDK2, the gene that manufactures CDK2 protein, dramatically slowed the growth and proliferation of the cancer cells. Unlike conventional chemotherapy drugs, a CDK2 inhibitor drug wouldn't be aimed at killing melanoma cells, only halting their growth.

Fisher said that CDK2-inhibiting drugs exist, and he hopes that the research results will soon lead to clinical trials of them in patients with melanoma.

The study's lead author is Jinyan Du, PhD, who carried out the project while working as a student in Fisher's lab at Dana-Farber. Fisher is also a pediatric oncologist at Dana-Farber/Children's Hospital Cancer Care.

The CDK2 gene and its protein (an enzyme) are one of several regulators of the cell cycle: That is, they help determine when a cell should be "resting" and when it should begin dividing to make more of itself. When cells become malignant, it is in part because their normal controls on growth and division are disabled, and they proliferate abnormally. Overactive CDK2 has been found in many types of cancer, making it a prime candidate for designer drugs that w
'"/>

Contact: Janet Haley Dubow
janet_haley@dfci.harvard.edu
617-632-5665
Dana-Farber Cancer Institute
20-Dec-2004


Page: 1 2 3

Related medicine news :

1. Scientists replicate hepatitis C virus in laboratory
2. Scientists identify brain regions that decide where we look
3. Scientists uncover new mechanism for the amygdala in fear recognition
4. Scientists discover recipe for life: eating the Polymeal cuts heart disease by 76%
5. Scientists study fish oil diet in bid to cut heart attack risks
6. Scientists discover enzyme crucial to the transportation of proteins within cells
7. Scientists turn on the gender lens on cardiovascular disease research
8. Scientists stalk PPAR-gamma, find novel cancer connection
9. Scientists align billion-year-old protein with embryonic heart defects
10. Scientists pinpoint flaw, offer new promise for stroke treatment
11. Scientists discover enzyme crucial to HIV replication

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Scientists identify protein critical melanoma growth

(Date:10/31/2014)... treatment and cost, patients with early stage breast ... (APBI) with proton therapy versus whole breast irradiation ... of Texas MD Anderson Proton Therapy Center. ... on typical patient characteristics, researchers used Medicare reimbursement ... types of partial and whole breast irradiation therapies ...
(Date:10/31/2014)... device to give cancer researchers an unprecedented microscopic look ... through the body, causing more than 90 percent of ... cells travel, the device could uncover new ways to ... university,s Whiting School of Engineering and its Institute for ... system recently in the journal Cancer Research . ...
(Date:10/31/2014)... North Shore Eye Care today announced ... Island and the addition of leading ophthalmologist, William S. ... North Shore Eye Care Medical Director, Jeffrey Martin, MD. ... the Department of Ophthalmology of Winthrop-University Hospital and has ... for more than 30 years. He has been named ...
(Date:10/31/2014)... Melbourne, Fl. (PRWEB) October 31, 2014 ... school for boys and girls in grades 6-12, ... the potential for sports injuries and concussions, becoming ... proactively administer the ImPACT (Immediate Post-Concussion Assessment and ... As a 'Former NFL Player' lawsuit grabs the ...
(Date:10/31/2014)... October 31, 2014 Triple Board Certified ... hair restoration services to transform the appearance of military ... American Academy of Facial Plastic and Reconstruction Surgery (AAFPRS) ... to restore the facial hair Jones lost during an ... The pro-bono hair restoration procedure, valued around $16,000, took ...
Breaking Medicine News(10 mins):Health News:Proton therapy shown to be less costly than some alternative radiotherapy techniques 2Health News:Proton therapy shown to be less costly than some alternative radiotherapy techniques 3Health News:Viewing cancer on the move: New device yields close-up look at metastasis 2Health News:Viewing cancer on the move: New device yields close-up look at metastasis 3Health News:William Kasper, MD Garden City Ophthalmologist, Joins Medical Staff at North Shore Eye Care 2Health News:William Kasper, MD Garden City Ophthalmologist, Joins Medical Staff at North Shore Eye Care 3Health News:Florida Air Academy Tackling Concussions Head-On 2Health News:Florida Air Academy Tackling Concussions Head-On 3Health News:Miami Hair Restoration Specialist Transforms Wounded Soldier 2
(Date:10/31/2014)... BARCELONA , October 31, 2014 ... infringe two Australian patents of B. Braun Melsungen AG (B. ... Australia safety IV catheters manufactured by Poly Medicure ... Australia proceeding number VID 463 of ... In the detailed judgment, Multigate was found to have ...
(Date:10/31/2014)... October 30, 2014 ... the addition of the  "Process Validation in the ... offering.      (Logo: http://photos.prnewswire.com/prnh/20130307/600769) , ,Key ... Risk Based Approach to Process Validation for Pharmaceutical ... FDA Process Validation Guidance ...
(Date:10/31/2014)... 2014 Though therapies are in their nascent ... show an annual increase of 16.2% over the 2010-2020 ... billion, according to Kalorama Information,s report, Stem Cell ... therapeutics that have gained or are expected to gain ... developers tackle ever more complicated conditions, stem cell therapies ...
Breaking Medicine Technology:B. Braun Wins Patent Disputes Against Poly Medicure Ltd's Australian Distributor Multigate Medical Devices Pty. Ltd. and Spanish Distributor Dextromédica S. L. 2Process Validation in the US and EU (Workshop, London) 2Process Validation in the US and EU (Workshop, London) 3Process Validation in the US and EU (Workshop, London) 4Report: Stem Cell Technologies Market Growing 2
Cached News: