HOME >> MEDICINE >> NEWS
Scientists identify protein critical to melanoma growth

BOSTON--Researchers at Dana-Farber Cancer Institute and Children's Hospital Boston have discovered that malignant melanoma, the potentially lethal skin cancer, can't grow without a steady supply of a protein that normal cells can do without.

The findings, which are published in the December issue of Cancer Cell, suggest that drugs that cut off melanoma cells' supply of the protein, called CDK2, might curb the growth of the dangerous skin cancer in patients, and with relatively low toxicity.

In theory, such a drug would leave normal cells unharmed and have many fewer side effects compared to standard chemotherapy.

Working with melanoma cells grown in the laboratory, the researchers, led by David E. Fisher, MD, PhD, Director of the Melanoma Program at Dana-Farber and the paper's senior author, showed that adding a chemical that quashed the activity of CDK2, the gene that manufactures CDK2 protein, dramatically slowed the growth and proliferation of the cancer cells. Unlike conventional chemotherapy drugs, a CDK2 inhibitor drug wouldn't be aimed at killing melanoma cells, only halting their growth.

Fisher said that CDK2-inhibiting drugs exist, and he hopes that the research results will soon lead to clinical trials of them in patients with melanoma.

The study's lead author is Jinyan Du, PhD, who carried out the project while working as a student in Fisher's lab at Dana-Farber. Fisher is also a pediatric oncologist at Dana-Farber/Children's Hospital Cancer Care.

The CDK2 gene and its protein (an enzyme) are one of several regulators of the cell cycle: That is, they help determine when a cell should be "resting" and when it should begin dividing to make more of itself. When cells become malignant, it is in part because their normal controls on growth and division are disabled, and they proliferate abnormally. Overactive CDK2 has been found in many types of cancer, making it a prime candidate for designer drugs that w
'"/>

Contact: Janet Haley Dubow
janet_haley@dfci.harvard.edu
617-632-5665
Dana-Farber Cancer Institute
20-Dec-2004


Page: 1 2 3

Related medicine news :

1. Scientists replicate hepatitis C virus in laboratory
2. Scientists identify brain regions that decide where we look
3. Scientists uncover new mechanism for the amygdala in fear recognition
4. Scientists discover recipe for life: eating the Polymeal cuts heart disease by 76%
5. Scientists study fish oil diet in bid to cut heart attack risks
6. Scientists discover enzyme crucial to the transportation of proteins within cells
7. Scientists turn on the gender lens on cardiovascular disease research
8. Scientists stalk PPAR-gamma, find novel cancer connection
9. Scientists align billion-year-old protein with embryonic heart defects
10. Scientists pinpoint flaw, offer new promise for stroke treatment
11. Scientists discover enzyme crucial to HIV replication

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:12/8/2018)... ... 2018 , ... Garland was recently honored with a Medical ... organizations through fun, creative and thoughtful fundraising. Garland’s philanthropic initiative called Spirit Week ... in northeast Ohio and across the country over the last nine years. The ...
(Date:12/8/2018)... ... December 07, 2018 , ... Caring.com, the nation’s most visited website for ... medical alert systems, to its list of top medical alert systems for 2019. The ... Medical Guardian was one of fourteen companies that qualified for the list based on ...
(Date:12/6/2018)... ... December 06, 2018 , ... ... of the Post-Acute Care Symposium (PACS). The meeting will take place May 9–10, ... Spring/Wound Healing Society meeting in San Antonio, Texas. , PACS is uniquely designed ...
(Date:12/6/2018)... (PRWEB) , ... December 06, 2018 , ... ... to cope with day-to-day life, there are alternative solutions. M.D.-formulated Relaxium Calm is ... Relaxium Calm ’s main ingredient is Sensoril®, an extract of the ashwagandha root. ...
(Date:12/6/2018)... LAKE CITY and KENOSHA, Wisc. (PRWEB) , ... December 06, 2018 ... ... Division I NCAA Team to purchase and install LED light fixtures containing Indigo-Clean ... , “We are excited to be at the forefront of collegiate gymnastics programs across ...
Breaking Medicine News(10 mins):
(Date:11/29/2018)... ... November 29, 2018 , ... More than 205,000 individuals have signed ... diabetes organizations to significantly increase funding for type 1 diabetes cure research after spending ... since then. , An estimated two million Americans are affected by type 1 diabetes, ...
(Date:11/28/2018)... RAMAT GAN, Israel (PRWEB) , ... November 28, ... ... Dikembe Mutombo is traveling to Israel’s Sheba Medical Center, Tel HaShomer this week ... built a hospital in his home country, the Democratic Republic of Congo. ...
(Date:11/28/2018)... ... ... Every year the Tennessee Kidney Foundation honors a member of the renal community ... proud and honored to announce that the 2019 honoree is our very own Dr. ... College in Dublin, where he studied biochemistry as an undergraduate and later received his ...
Breaking Medicine Technology:
Cached News: