HOME >> MEDICINE >> NEWS
Screening for virus RNA could increase safety of organ & tissue transplantation

This release is also available in German.

Results of a study in this week's issue of THE LANCET suggest that routine screening of blood samples to detect viral RNA among organ and tissue donors who do not have obvious signs of clinical disease would reduce the risk of disease transmission among transplant recipients.

The presence of blood antibodies to viral diseases such as HIV and hepatitis C is the conventional method for assessing whether an individual is safe to be a tissue or organ donor. However this approach is limited; some donors may be infected with a virus but have not yet 'seroconverted' (shown a full immune response to infection by producing antibodies), thereby posing a risk to transplant recipients.

Jean-Michel Pawlotsky (Hpital Henri Mondor, Paris, France) and colleagues determined whether nucleic acid testing (NAT) could detect HIV RNA or hepatitis C virus (HCV) RNA in a large series of seronegative organ and tissue donors, and whether this technique should be routinely used to improve viral safety of grafts. They studied 2236 organ donors, 636 tissue donors, and 177 cornea donors. The investigators identified five HCV RNA-positive donors in 2119 HCV-seronegative organ donors, and one HCV RNA-positive donor in 631 HCV-seronegative tissue donors. No HIV-seronegative, HIV RNA-positive donor was identified.

Dr Pawlotsky comments: "our data, together with the reported cases of HCV transmission to recipients from a seronegative HCV RNA-positive donor, suggest that routine NAT screening of organ and tissue donors might increase viral safety in the transplantation setting. Implementation of systematic NAT screening of tissue (and cell) donors is highly feasible because viral testing can be done every day and can be based on standardised, partly automated, commercial techniques and proceduresTechnical flaws currently hinder routine NAT scree
'"/>

Contact: Joe Santangelo
j.santangelo@elsevier.com
1-212-633-3810
Lancet
28-Oct-2004


Page: 1 2

Related medicine news :

1. Screening for osteoporosis prevents hip fractures in older adults
2. Screening for genital herpes should be targeted
3. Screening for liver diseases
4. Screening removes West Nile from bood supply
5. Screening for depression at primary level could be next trend in healthcare
6. Screening men for aortic aneurysms justified
7. Screening children for speech problems is ineffective
8. Screening for aortic aneurysms is cost effective
9. Screening the general population for colorectal cancer
10. National Lung Screening Trial
11. Screening reduces mastectomy rates

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:9/17/2019)... (PRWEB) , ... September 17, 2019 , ... ... to join the largest accountable care organization (ACO) in the country, the company ... this groundbreaking collaboration to improve care quality and increase cost efficiency. This opportunity ...
(Date:9/17/2019)... ... 17, 2019 , ... Dr. Perry Patel, the dentist ... the American Academy of Facial Esthetics (AAFE) to administer Botox and dermal filler ... conditions such as tooth clenching and grinding, tongue tension, temporomandibular joint disorders, commonly ...
(Date:9/17/2019)... ... September 17, 2019 , ... The Center for Information ... of the third edition of The Gift of Participation. Written by CISCRP Founder, ... families to navigate the clinical research process. The new edition offers a fresh ...
(Date:9/14/2019)... (PRWEB) , ... September 13, ... ... Society (WMIS) showcased several first-in-human studies on the detection and treatment of ... two examples of these ground-breaking studies were noninvasive detection of residual HIV ...
(Date:9/11/2019)... ... September 12, 2019 , ... “Heart Seizures”: a useful ... coronary artery disease as he hopes to prevent anyone from having it and to ... author John Saltwick, a writer who was diagnosed with coronary artery disease. Predicted to ...
Breaking Medicine News(10 mins):
(Date:9/17/2019)... Ill. (PRWEB) , ... September 17, 2019 , ... ... Illinois has joined the esteemed Haute Beauty network. , The Haute Beauty Network, ... to present Dr. Babis Rammos as a body expert and our newest addition ...
(Date:9/14/2019)... ... September 13, 2019 , ... Braun Industries, Crestline Coach Ltd, and ... service and wish him well on his retirement. Braun Industries and Crestline Coach invite ... contact them direct for inquires related to new ambulance sales and service. , ...
(Date:9/14/2019)... ... September 14, 2019 , ... ... plaintiffs living with peritoneal mesothelioma, a jury in Middlesex County found Johnson & ... of plaintiffs alleging their mesotheliomas were caused by asbestos-containing J&J talc products. ...
Breaking Medicine Technology:
Cached News: