HOME >> MEDICINE >> NEWS
Scripps Research Institute group designs DNA vaccine that inhibits growth of cancerous tumors

A group of researchers at The Scripps Research Institute (TSRI) have developed a novel DNA vaccine that helps the body resist the growth of cancerous tumors by choking off the tumors' blood supply.

"We stimulate the immune system to recognize proliferating blood vessels in the tumor vasculature and to recruit killer T cells to destroy these vessels," explains TSRI Immunology Professor Ralph Reisfeld, Ph.D., who conducted the study with Research Associate Andreas G. Niethammer, M.D., and others. "Deprived of its blood supply, the tumor [eventually dies]."

Niethammer, Reisfeld, and their collaborators describe their successful pre-clinical studies with the vaccine in an article to be published next month in the journal Nature Medicine.

Though not yet tested in humans, their vaccine has the potential to treat many types of cancer, and it may provide a new strategy for the rational design of cancer therapies.

Two Approaches to Treating Cancer

Cancer is not a single disease, but rather over a hundred diseases caused by various sorts of mutations inside various cells in various tissues. Some mutations upregulate genes, increasing the expression of metalloproteinases for instance; others downregulate them, shutting off production of receptor proteins.

After certain mutations occur, a cancer cell grows out of control, dividing over and over and forming a solid tumor. Cancer tumors often damage the tissues where they are located and some can metastasize and migrate through the bloodstream--the malignant carcinoma that claims so many lives every year.

In recent years, some novel approaches to treating cancer have generated interest in scientific circles and society at large.

One of these approaches to is to try to block the process of angiogenesis, the formation of new blood vessels that bring necessary nutrients and oxygen to the hungry tumor cells. Block angiogenesis, the thinking goes, and you can
'"/>

Contact: Keith McKeown
kmckeown@scripps.edu
858-784-8134
Scripps Research Institute
4-Nov-2002


Page: 1 2 3 4

Related medicine news :

1. Scripps atmospheric scientist appointed to Pontifical Academy of Sciences
2. Chemical turns stem cells into neurons say scientists at Scripps Research Institute
3. Sepsis vaccine proves protective in preliminary studies at The Scripps Research Institute
4. Researchers search for first sign of congestive heart failure
5. Research offers hope of new treatments for liver damage
6. Research suggests possible blood test for multiple sclerosis
7. Researchers say breast cancer in Africa may provide clues to the disease in African-Americans
8. 2005 Award for Basic Research in Biological Mineralization
9. 2005 Craniofacial Biology Research Award
10. 2005 Research in Dental Caries Award
11. 2005 Research in Prosthodontics and Implants Award

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/8/2016)... ... February 08, 2016 , ... ... area, has selected the latest beneficiary of their ongoing community enrichment program. The ... bullying in area schools. Donations are now being accepted at: http://www.angelsanddoves.com/donate.html . ...
(Date:2/8/2016)... , ... February 08, 2016 ... ... security executive networking and relationship-marketing firm, announced today that nominations will be ... Security Executive® (ISE®) West Awards. , Awards include the Information Security ...
(Date:2/8/2016)... ... February 08, 2016 , ... FileHold's document ... organizations. DocuSyst provides a cloud hosted environment for FileHold software that is pay ... various 3rd party applications using the FileHold web services API. DocuSyst also advises ...
(Date:2/8/2016)... ... February 08, 2016 , ... The Association of ... AHCC and the Home Health and Hospice ICD-10 Transition Workgroup are working closely ... coding guidance and clarifications, to address concerns over the use of 'A' as ...
(Date:2/8/2016)... ... February 08, 2016 , ... Guruji Mahendra Kumar Trivedi is offering ... 2016 in honor of his birthday on February 10th. During this time, people ... is known by over 250,000 people from over 40 different countries as an “ordinary ...
Breaking Medicine News(10 mins):
(Date:2/8/2016)... , Feb. 8, 2016   GS1 US ... to guide them through GS1 Standards implementation to address ... (FDA) Unique Device Identification (UDI) rule. ... Beth Gibson , senior director industry development, medical ... development director, GS1 US --> ...
(Date:2/8/2016)... LEAWOOD, Kan. , Feb. 8, 2016 ... held organization that formerly specialized in the ... facilities, recently announced that it has divided ... Nueterra Capital. While Nueterra Capital will continue ... advisory services, NueHealth will operate a national ...
(Date:2/8/2016)... 2016   HighPoint Solutions today announced ... pharmacovigilance technology services division.  NRG is a leading ... Oracle Argus Specialized partner, providing drug safety system ... --> --> ... capabilities and provides a global scale and infrastructure ...
Breaking Medicine Technology:
Cached News: