HOME >> MEDICINE >> NEWS
Second NIAID SARS vaccine candidate helps mice fend off SARS

An experimental vaccine based on a critical piece of the SARS virus protects mice from SARS infection, researchers from the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health, have found. When exposed to the SARS virus, immunized mice produced SARS-specific antibodies, and virus replication was nearly eliminated.

The new report, to be published this week in the Proceedings of the National Academy of Sciences online, is the second from NIAID in recent weeks describing a promising SARS vaccine candidate.

"We now have two candidate vaccines, based on two distinct technologies, shown to be effective against SARS infection in mice," says NIAID Director Anthony S. Fauci, M.D. "The animal model employed in both studies was developed by NIAID researchers as well. By taking various approaches to vaccine development, we are making significant research progress against a disease that was unknown little more than a year ago."

SARS is caused by a coronavirus, a family of viruses so named because spiky proteins protrude from the virus's surface, giving the microbe a crown-like appearance. The newly described vaccine is based on the spike (S) protein. Because the virus initiates infection by attaching to and entering cells using its S protein, a vaccine based on this protein should closely mimic natural infection, notes senior author, Bernard Moss, M.D., Ph.D.

Investigators inserted the gene encoding the S protein into a virus called modified vaccinia Ankara (MVA). Neither MVA nor the solitary gene from the SARS virus can cause disease. Instead, MVA simply ferries the SARS gene into the body. First developed as a vaccine against smallpox, MVA has an excellent safety record in humans, says Dr. Moss, and it efficiently stimulates both the antibody and cellular arms of the immune system.

Dr. Moss and his colleagues collaborated in this research with fellow NIAID scientist Kanta Subbarao,
'"/>

Contact: Anne A. Oplinger
aoplinger@niaid.nih.gov
301-402-1663
NIH/National Institute of Allergy and Infectious Diseases
19-Apr-2004


Page: 1 2

Related medicine news :

1. Secondhand smoke linked to cervical cancer
2. Secondhand smoke impairs lung function in women
3. Second stage of HIV vaccine trial begins in London and Oxford, UK
4. Second patient with multiple sclerosis undergoes groundbreaking surgery at Yale
5. Cholesterol Carriers Better Predictors Than Cholesterol For Second Heart Attack
6. Second Annual AIDS Vaccine Day Honors Volunteers Nationwide
7. Patients Treated Successfully For Hodgkins Disease Are At 9 Times The Risk For Developing Second Cancer
8. Cedars-Sinai Medical Centers Prenatal Program Pushes the Frontiers of Diagnosis From the Second Trimester Into the First
9. AAPS Sponsors Second Frontier Symposium
10. Drug Combination Including New "Super Aspirin" Drug Cuts Risk Of Death Or Second Heart Attack
11. Drugs Effect On Chromosomes May Explain Second Cancers

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Second NIAID SARS vaccine candidate helps mice fend off SARS

(Date:9/1/2015)... ... September 01, 2015 , ... Royal River Natural Foods, a locally-owned independent ... and women for 19 years and found that, among those who had a stroke, ... The report is part of the September 2015 issue of “Natural Insights for Well ...
(Date:9/1/2015)... CA (PRWEB) , ... September 01, 2015 , ... Agriculture ... just a few of the topics to be discussed at Seedstock’s 4th Annual Sustainable ... 3-4, 2015, at UC San Diego. , In addition to keynotes Pierre Sleiman, ...
(Date:9/1/2015)... ... 2015 , ... Mercy Health (formerly Catholic Health Partners) – a Catholic healthcare ... Health: Helping You Be Well videos to prostate cancer awareness. Prostate cancer is the ... concise video on Mercy Health’s YouTube channel, Mercy Health experts address issues, such as:, ...
(Date:9/1/2015)... ... September 01, 2015 , ... Situations ... seldom arise at the most convenient time for everyone involved. These occasions highlight ... , Universal Translation Services has real people available to handle any ...
(Date:9/1/2015)... Toronto, Canada (PRWEB) , ... ... ... Technologies announce PRO Archiver for Alfresco, a next-generation customer communications archiving ... is built with market-leading technology from Crawford and helps organizations save millions ...
Breaking Medicine News(10 mins):Health News:New Study Finds Multivitamins Extend Life After Stroke, Retailer Reports 2Health News:Experts in Urban and Local Food Systems Development to Address Seedstock Sustainable Agriculture Conference Nov. 3-4 Discounted ticket sales end Sept. 4 2Health News:Experts in Urban and Local Food Systems Development to Address Seedstock Sustainable Agriculture Conference Nov. 3-4 Discounted ticket sales end Sept. 4 3Health News:Experts in Urban and Local Food Systems Development to Address Seedstock Sustainable Agriculture Conference Nov. 3-4 Discounted ticket sales end Sept. 4 4Health News:Experts in Urban and Local Food Systems Development to Address Seedstock Sustainable Agriculture Conference Nov. 3-4 Discounted ticket sales end Sept. 4 5Health News:New Mercy Health Video Explains Most-Common Cancer Found in Men 2Health News:Universal Translation Services Provides Quality Translations 24 Hours a Day Including Weekends 2Health News:Universal Translation Services Provides Quality Translations 24 Hours a Day Including Weekends 3Health News:Introducing Next-Generation Archiving Solution PRO Archiver for Alfresco® 2Health News:Introducing Next-Generation Archiving Solution PRO Archiver for Alfresco® 3
(Date:8/31/2015)... Pepperl+Fuchs, a world leader in process ... leading provider of HART protocol devices. The move ... its integrated solutions offerings and strengthen its position ... are pleased to add the MACTek WirelessHART product ... Bolin , Pepperl+Fuchs, executive vice president of the ...
(Date:8/31/2015)... 2015 Thousands of people will peacefully demonstrate ... opioid addiction epidemic at dozens of rallies across the ... the United States has experienced ... opioids and heroin, yet the President has never once ... letter to President Obama , rally organizers compared ...
(Date:8/31/2015)... York , August 31, 2015 ... states that the global cardiovascular monitoring and diagnostic ... and is predicted to reach a value of ... CAGR of 9.7% between 2013 and 2019. The ... Diagnostic Devices Market (ECG, Holter Monitors, Event Monitors, ...
Breaking Medicine Technology:Obama Administration's Neglect of Opioid Crisis Prompts Rallies in Many States 2Cardiovascular Monitoring and Diagnostic Devices Market to Reach US$7.0 Billion in 2019 Owing to Global Rise in Diabetes and Obesity: Transparency Market Research 2Cardiovascular Monitoring and Diagnostic Devices Market to Reach US$7.0 Billion in 2019 Owing to Global Rise in Diabetes and Obesity: Transparency Market Research 3Cardiovascular Monitoring and Diagnostic Devices Market to Reach US$7.0 Billion in 2019 Owing to Global Rise in Diabetes and Obesity: Transparency Market Research 4Cardiovascular Monitoring and Diagnostic Devices Market to Reach US$7.0 Billion in 2019 Owing to Global Rise in Diabetes and Obesity: Transparency Market Research 5
Cached News: