HOME >> MEDICINE >> NEWS
Second NIAID SARS vaccine candidate helps mice fend off SARS

An experimental vaccine based on a critical piece of the SARS virus protects mice from SARS infection, researchers from the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health, have found. When exposed to the SARS virus, immunized mice produced SARS-specific antibodies, and virus replication was nearly eliminated.

The new report, to be published this week in the Proceedings of the National Academy of Sciences online, is the second from NIAID in recent weeks describing a promising SARS vaccine candidate.

"We now have two candidate vaccines, based on two distinct technologies, shown to be effective against SARS infection in mice," says NIAID Director Anthony S. Fauci, M.D. "The animal model employed in both studies was developed by NIAID researchers as well. By taking various approaches to vaccine development, we are making significant research progress against a disease that was unknown little more than a year ago."

SARS is caused by a coronavirus, a family of viruses so named because spiky proteins protrude from the virus's surface, giving the microbe a crown-like appearance. The newly described vaccine is based on the spike (S) protein. Because the virus initiates infection by attaching to and entering cells using its S protein, a vaccine based on this protein should closely mimic natural infection, notes senior author, Bernard Moss, M.D., Ph.D.

Investigators inserted the gene encoding the S protein into a virus called modified vaccinia Ankara (MVA). Neither MVA nor the solitary gene from the SARS virus can cause disease. Instead, MVA simply ferries the SARS gene into the body. First developed as a vaccine against smallpox, MVA has an excellent safety record in humans, says Dr. Moss, and it efficiently stimulates both the antibody and cellular arms of the immune system.

Dr. Moss and his colleagues collaborated in this research with fellow NIAID scientist Kanta Subbarao,
'"/>

Contact: Anne A. Oplinger
aoplinger@niaid.nih.gov
301-402-1663
NIH/National Institute of Allergy and Infectious Diseases
19-Apr-2004


Page: 1 2

Related medicine news :

1. Secondhand smoke linked to cervical cancer
2. Secondhand smoke impairs lung function in women
3. Second stage of HIV vaccine trial begins in London and Oxford, UK
4. Second patient with multiple sclerosis undergoes groundbreaking surgery at Yale
5. Cholesterol Carriers Better Predictors Than Cholesterol For Second Heart Attack
6. Second Annual AIDS Vaccine Day Honors Volunteers Nationwide
7. Patients Treated Successfully For Hodgkins Disease Are At 9 Times The Risk For Developing Second Cancer
8. Cedars-Sinai Medical Centers Prenatal Program Pushes the Frontiers of Diagnosis From the Second Trimester Into the First
9. AAPS Sponsors Second Frontier Symposium
10. Drug Combination Including New "Super Aspirin" Drug Cuts Risk Of Death Or Second Heart Attack
11. Drugs Effect On Chromosomes May Explain Second Cancers

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/1/2017)... , ... March 01, 2017 , ... ... healing grace in the lives of those who hear His voice. “Cleansing Thoughts; ... a retired Christian bookstore proprietor who enjoys boating, gardening and crocheting baby items ...
(Date:3/1/2017)... (PRWEB) , ... March 01, 2017 , ... “Our Pure Need of Obedience to the ... preparation for His return. “Our Pure Need of Obedience to the Law of God” is ... to attend missionary school. He and his wife, Anika, and children have since dedicated their ...
(Date:2/28/2017)... ... ... e-Zest Solutions ( http://www.e-zest.com ) – Digital Transformation leader ... intelligent mobile platform that is enabling sales people at small businesses to Fortune ... users in mind unlike most enterprise software, to improve their productivity by making ...
(Date:2/28/2017)... ... February 28, 2017 , ... Many of the country’s top ... Solutions to Healthcare’s Greatest Challenges,” during Intalere’s 2017 Executive Forum, taking place March ... Forum assembles the best and brightest healthcare leaders to exchange experiences, expertise and ...
(Date:2/28/2017)... Baltimore, MD (PRWEB) , ... February 28, 2017 , ... ... Healthcare are co-hosting a Wellness Day on March 4, 2017 from 10:00 a.m. to ... San Mateo and Menaul Blvds. , The goal of the Wellness Day is to ...
Breaking Medicine News(10 mins):
(Date:3/1/2017)... , March 1, 2017 The global  Intraoperative Neuromonitoring ... a new report by Grand View Research, Inc. The intraoperative neuromonitoring market is ... to the hospitals adopting intraoperative monitoring in a wide spectrum of surgeries. ... ... Grand View Research Logo ...
(Date:2/28/2017)... -- Prefilled Syringes Market: Scope and Segmentation Download ... report provides a forecast and analysis of the ... levels. It provides historical data of 2015 along ... of revenue (US$ Mn) and volume (Bn Units). ... an outlook on prefilled syringes consumption globally. It ...
(Date:2/28/2017)... , Feb. 28, 2017 Persistence Market ... global dysphagia management market in a new publication ... Forecast 2016-2024." As the name suggests, we have ... geographical regions and on the basis of the ... assessment of the opportunities available to all the ...
Breaking Medicine Technology:
Cached News: