HOME >> MEDICINE >> NEWS
Sedative may offer new direction in colon cancer treatment

ORLANDO -- A barbiturate once commonly used to treat anxiety may play a role in controlling the spread of colon cancer, say researchers from The University of Texas M. D. Anderson Cancer Center.

Their experimental model of colon cancer -- work done in cell cultures and animal studies -- demonstrates that the drug, Nembutal, can suppress activity in colon cancer cells the same way it inhibits certain kinds of neurotransmissions in the brain and central nervous system.

The results, presented at the annual meeting of the American Association for Cancer Research, suggest a novel approach to treatment of cancers now known to have neurotransmitter receptors on the outside of their cells. That includes, to date, colon and some ovarian cancers.

"This is the first experimental evidence that Nembutal is a potent inhibitor of colon cancer metastasis," says the study's first author, Premal Thaker, M.D., a clinical fellow in the Department of Gynecologic Oncology. "These findings may have therapeutic implications for treatment, but more work needs to be done before we know that."

Scientists have only recently discovered that the surfaces of colon cancer cells are studded with receptors for gamma-aminobutyric acid (GABA), an inhibitory neurotransmitter.

Nerve cells, or neurons, communicate by releasing neurotransmitters. These chemical messengers flow onto other neurons that act as receivers. The neurotransmitter attaches to a slot on the neuron, or receptor site. Once attached, different neurotransmitters either trigger "go" signals that allow the message to be passed on to other cells or produce "stop" signals that prevent the message from being forwarded. GABA is the most common message-altering neurotransmitter in the brain, inhibiting the transfer of other neurotransmitters as well as other chemical signals, such as hormones.

Nembutal is a member of the barbiturate family of drugs commonly known as "downers" -- acting just lik
'"/>

Contact: Julie Penne
jpenne@mdanderson.org
713-792-0655
University of Texas M. D. Anderson Cancer Center
30-Mar-2004


Page: 1 2

Related medicine news :

1. UCSF study offers insight into human circadian rhythms
2. Research offers hope of new treatments for liver damage
3. Portable system offers dialysis patients liberating changes
4. New laparoscopic hysterectomy offers quicker recovery time than traditional surgery
5. UIC offers new weight loss surgery for obese teens
6. Radiologists offer non-surgical treatment for early-stage liver cancer
7. COX-2 product offers good and bad news in test tube strokes
8. Researchers offer emergency workers a lifeline
9. Least protection offered to those most at risk of sudden cardiac death
10. Clinical breast examination offers modest benefit to breast cancer screening program
11. Mayo Clinic discovery on nature of rheumatoid arthritis lung disease may offer patients therapy

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Sedative may offer new direction colon cancer treatment

(Date:11/28/2014)... Recently, BellasDress , a renowned dress manufacturer in ... line of cocktail dresses. In addition, these fresh dresses are ... free shipping on orders over $179. The aim of the ... is providing many styles of dresses, which come in various ... and more. All of them are on sale at affordable ...
(Date:11/28/2014)... Recently, PrettyTailor.com has developed and created its ... around the world in celebration of the coming holiday ... launched a special offer on all these outfits. ... pioneer in the garment industry, PrettyTailor.com brings together art ... and small. The business carries quite a few in ...
(Date:11/28/2014)... Nov. 28, 2014 (HealthDay News) -- People with diabetes face ... can help keep you healthy, an expert says. "With ... you,ll deal with the events, the family you,ll be visiting ... American Association of Diabetes Educators, said in an association news ... still be healthy." One idea is to make a ...
(Date:11/28/2014)... 29, 2014 BambooFlooringChina.com has been recognized ... industry. Recently, the business has announced its new ... offering big discount on these new models. , Based ... by hands, without carpenter machines involved. It is crafted ... is great for do-it-yourselfers without hard work on installation, ...
(Date:11/28/2014)... 2014 Dr. Diane Walder, one of ... the addition of Dr. Bridgit Nolan to her practice ... after having completed her dermatology residency at the University ... invited Dr. Nolan to join her practice ... cosmetic dermatology. Not only does Dr. Nolan strive to ...
Breaking Medicine News(10 mins):Health News:BellasDress Offers A Big Surprise By Updating Its Cheap and Charming Cocktail Dresses 2Health News:2015 Wedding Dresses from PrettyTailor.com Available Now 2Health News:Holiday Eating Tips for People With Diabetes 2Health News:BambooFlooringChina.com Introduces Its New Strand Woven Bamboo Flooring Collection 2Health News:Dr. Diane Walder Welcomes New Cosmetic Dermatologist to Practice 2
(Date:11/26/2014)... Nov. 26, 2014  Aethlon Medical, Inc. (OTCQB:AEMD), announced ... to raise approximately $3.3 million at a price of ... one institutional healthcare focused investor. Each unit consists of one ... share purchase warrant. Each whole warrant entitles the holder ... $0.30 for a period of five years from closing.  ...
(Date:11/26/2014)... 26, 2014  Cohen, Placitella & Roth, PC ... who purchased Nymox Pharmaceutical Corporation ("Nymox" or "Company") ... from January 31, 2011 through November 2, 2014 ... certain of its officers and directors publically disseminated ... Sections 10(b) and 20(a) of the Securities Exchange ...
(Date:11/26/2014)... THE WOODLANDS, Texas , Nov. 26, 2014 ... LXRX ) today announced the completion of previously ... of $280.0 million.  After fees and estimated offering ... million from the transactions.  The transactions consisted of: ... shares of common stock, pursuant to a registration ...
Breaking Medicine Technology:Aethlon Medical Announces $3.3 Million Equity Investment 2Aethlon Medical Announces $3.3 Million Equity Investment 3Cohen, Placitella & Roth, PC Investigating Nymox Pharmaceutical Corporation for Failing to Disclose Material Information 2Cohen, Placitella & Roth, PC Investigating Nymox Pharmaceutical Corporation for Failing to Disclose Material Information 3Lexicon Announces Completion Of $280 Million In Financing Transactions 2Lexicon Announces Completion Of $280 Million In Financing Transactions 3
Cached News: