HOME >> MEDICINE >> NEWS
Sedative may offer new direction in colon cancer treatment

ORLANDO -- A barbiturate once commonly used to treat anxiety may play a role in controlling the spread of colon cancer, say researchers from The University of Texas M. D. Anderson Cancer Center.

Their experimental model of colon cancer -- work done in cell cultures and animal studies -- demonstrates that the drug, Nembutal, can suppress activity in colon cancer cells the same way it inhibits certain kinds of neurotransmissions in the brain and central nervous system.

The results, presented at the annual meeting of the American Association for Cancer Research, suggest a novel approach to treatment of cancers now known to have neurotransmitter receptors on the outside of their cells. That includes, to date, colon and some ovarian cancers.

"This is the first experimental evidence that Nembutal is a potent inhibitor of colon cancer metastasis," says the study's first author, Premal Thaker, M.D., a clinical fellow in the Department of Gynecologic Oncology. "These findings may have therapeutic implications for treatment, but more work needs to be done before we know that."

Scientists have only recently discovered that the surfaces of colon cancer cells are studded with receptors for gamma-aminobutyric acid (GABA), an inhibitory neurotransmitter.

Nerve cells, or neurons, communicate by releasing neurotransmitters. These chemical messengers flow onto other neurons that act as receivers. The neurotransmitter attaches to a slot on the neuron, or receptor site. Once attached, different neurotransmitters either trigger "go" signals that allow the message to be passed on to other cells or produce "stop" signals that prevent the message from being forwarded. GABA is the most common message-altering neurotransmitter in the brain, inhibiting the transfer of other neurotransmitters as well as other chemical signals, such as hormones.

Nembutal is a member of the barbiturate family of drugs commonly known as "downers" -- acting just lik
'"/>

Contact: Julie Penne
jpenne@mdanderson.org
713-792-0655
University of Texas M. D. Anderson Cancer Center
30-Mar-2004


Page: 1 2

Related medicine news :

1. UCSF study offers insight into human circadian rhythms
2. Research offers hope of new treatments for liver damage
3. Portable system offers dialysis patients liberating changes
4. New laparoscopic hysterectomy offers quicker recovery time than traditional surgery
5. UIC offers new weight loss surgery for obese teens
6. Radiologists offer non-surgical treatment for early-stage liver cancer
7. COX-2 product offers good and bad news in test tube strokes
8. Researchers offer emergency workers a lifeline
9. Least protection offered to those most at risk of sudden cardiac death
10. Clinical breast examination offers modest benefit to breast cancer screening program
11. Mayo Clinic discovery on nature of rheumatoid arthritis lung disease may offer patients therapy

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/23/2017)... , ... May 23, 2017 , ... Allegheny Health ... open The Alexis Joy D’Achille Center for Women’s Behavioral Health at West Penn ... in western Pennsylvania for women suffering from pregnancy-related depression. Construction of the Center ...
(Date:5/23/2017)... ... , ... The National Council on Strength and Fitness (NCSF), ... Certified Strength Coach credential has earned accreditation from the National Commission for Certifying ... of qualified candidates for jobs in the Strength and Conditioning profession. The CSC ...
(Date:5/23/2017)... ... May 23, 2017 , ... MedTech ... in the modern ART laboratory, to provide hands-on training utilizing cutting-edge equipment at ... NextGen LifeLabs, a MedTech Group Purchasing vendor , will provide specialized equipment ...
(Date:5/23/2017)... CA (PRWEB) , ... May 23, 2017 , ... ... can now receive treatment using the SPEED System™ Orthodontics, with or without a ... orthodontist in El Segundo, CA, who is skilled in providing patients ...
(Date:5/22/2017)... NC (PRWEB) , ... May 22, 2017 , ... ... Matthews Periodontics, is now welcoming new patients with periodontal plastic surgery treatments, including ... from a general dentist. Dr. Green provides these esthetic and functional procedures to ...
Breaking Medicine News(10 mins):
(Date:5/18/2017)... , May 17, 2017  Bayer announced today ... portfolio will be presented at the 53 rd ... (ASCO), taking place June 2-6 in Chicago ... at ASCO span prostate, colorectal, liver and thyroid cancers, ... from the Phase II CHRONOS-1 trial of copanlisib in ...
(Date:5/12/2017)... and Canada joint tech company Laughing Face has ... detergent, and features a powerful disinfection process. The company ... washes and sanitizes women,s panties or babies, cloth diapers in 25 ... ... an external water inlet. ...
(Date:5/10/2017)... , May 10, 2017 Global Health ... Latin America , published its 2017 ranking ... ranking is based on extensive data analysis from GHI,s ... largest hospitals database for the region. The GHI database covers ... , offering more than 130 data points for each institution ...
Breaking Medicine Technology:
Cached News: