HOME >> MEDICINE >> NEWS
Self-assembled nano-capsules resemble bacterial cell walls

CHAMPAIGN, Ill. -- By manipulating simple and nonspecific interactions, researchers have discovered a way to make chemicals spontaneously self-assemble into ribbon-like tubules that resemble bacterial cell walls. The micrometer-sized tubules have potential applications in drug delivery systems and as templates for the synthesis of inorganic nanostructured materials.

"The 'artificial bacteria' consist of the biopolymer actin attached to charged lipid membranes," said Gerard Wong, a professor of materials science and of physics at the University of Illinois. Wong was the lead author of a paper published in the June 16 issue of the journal Science that described the assembly process. "The resulting actin-membrane capsules are fairly rigid and quite stable," he said.

Actin is a protein that provides the structural framework in eukaryotic cells and forms the molecular basis for biological functions as diverse as hearing, muscle contraction and cell division. When mixed with special liposomes, the researchers found, actin immediately undergoes a hierarchical self-assembly process that results in the formation of nano-scale tubular capsules.

"The composite membrane is organized into three layers," Wong said. "A middle lipid layer, similar to the plasma membrane that surrounds most cells, is sandwiched between two layers of actin filaments. The filaments first arrange themselves into two-dimensional parallel arrays on both sides of the lipid layer, and then they spontaneously wrap into tubules."

The spaces between the layers are filled with water and could be used for a variety of applications, including the packaging of certain drugs that would be slowly released to the body. The nano-capsules also could be used as miniature templates in novel, inorganic nanofabrication techniques.

While the structures have no real analog in nature, this type of spontaneous organization is reminiscent of multi-layered bacterial cell walls, Wong said. The protein-
'"/>

Contact: James E. Kloeppel, Physical Sciences Editor
kloeppel@uiuc.edu
217-244-1073
University of Illinois at Urbana-Champaign
2-Jul-2000


Page: 1 2

Related medicine news :

1. When switched on muscle stem cells morph to resemble nerve cells
2. Discovery of key proteins shape could lead to improved bacterial pneumonia vaccine
3. Outbreak of skin infections sheds light on risk factors for bacterial resistance
4. UCSD researchers decipher function of blood-brain barrier in bacterial meningitis
5. Single protein is key in response to bacterial, viral infections
6. Anti-bacterial spice that kills food germs on agenda for ACS meeting in New Orleans
7. Researchers show beneficial role of bacterial DNA in fighting inflammatory bowel disease
8. Experts announce global antimicrobial resistance initiative - World preview of the Global White Paper on bacterial resistance in respiratory tract infections - a call for concerted international action
9. Arizona researchers receive award for antibacterial, foaming hand wash
10. Widely used anti-bacterial inhibits parasites that cause malaria and toxoplasmosis
11. Process may help scientists find new antibacterial drugs

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/28/2020)... ... May 28, 2020 , ... With a ... fall, operators of student housing are scrambling to implement practices that will help ... 37,000 student housing beds on 38 campuses across the country, has researched best ...
(Date:5/26/2020)... ... May 26, 2020 , ... ... can impact the brain causing post infectious encephalitis. The work was conducted ... and PANS (Pediatric Acute-onset Neuropsychiatric Syndrome) could adversely attack the central nervous ...
(Date:5/25/2020)... ... 2020 , ... Winemaker Grant Long Jr. is introducing three Toilet Paper Reserve ... delicious in these complicated times,” he said, in announcing the new wines. The wines ... Chardonnay and Red Wine Blend are sourced in the Napa Valley; the Grenache comes ...
(Date:5/21/2020)... ... May 21, 2020 , ... Having ... of GSCG, VITA NOVAS has already gained ground with the inherited reputation of ... stimulating biological products intravenously, guaranteeing an effective way for the ingredients to become ...
(Date:5/21/2020)... ... May 21, 2020 , ... The Rise of Mental Health and Substance Abuse ... complications and adjustments, needless to say, more complications. With rising deaths, more confirmed cases ... it can be hard to escape and find peace. Adding to these persistent stressors ...
Breaking Medicine News(10 mins):
(Date:5/26/2020)... ... May 26, 2020 , ... SignatureCare Emergency Center, your ... Pflugerville, TX . , The new ER is set to open early June, 2020, ... Road at 21315 N SH 130, Bldg.4, Pflugerville, TX. , According to Dr. ...
(Date:5/25/2020)... ... May 24, 2020 , ... May is National Electrical Safety ... public to know what safety resources are available. Every year during National ... education campaign to inform the public about safety steps that can reduce the ...
(Date:5/21/2020)... ... , ... The COVID-19 outbreak has changed the world we live in almost ... & Academy (IA) have closely followed the recommendations of the Centers for Disease Control ... spread of coronavirus, and keep students, campers, parents, guests and SPIRE employees as safe ...
Breaking Medicine Technology:
Cached News: