HOME >> MEDICINE >> NEWS
Several new techniques show promise for spinal cord repair

by analyzing its carrier molecule, as the nanospheres slowly degraded. Other experiments confirmed that the design of the nanospheres is effective in adhering the nanospheres to the chondroitin sulfate and that it has no toxic effects on cultured neurons.

The researchers are currently using these cABC nanospheres to treat spinal cord injury in rats. They have injected 3 or 6 m l of nanospheres immediately or one week following spinal contusion injury, or into uninjured spinal cord. Results so far show that the nanospheres remain near the injection site, and do not cause any major inflammation of spinal tissue, Stelzner says.

"A unique feature of the nanosphere delivery system," Stelzner says, "is its ability to encapsulate other agents, in addition to cABC, that can be administered together, but released at various times, to counteract the inhibitory substances, and to target and promote regrowth in the spinal cord."

Aside from blocking the growth-inhibiting molecules present after injury to aid in spinal cord regeneration, nerve cells also can be altered internally so they no longer recognize the inhibitory molecules as hindering growth, and instead grow right through them. Marie Filbin, PhD, in the department of biological sciences at Hunter College and her team were able to use this approach to regrow spinal cord nerve cells using a drug called Rolipram.

First, researchers conducted in vitro studies in which nerve cells were removed from Rolipram-treated rats and exposed them to molecules that inhibited nerve regrowth. They found that if cyclic AMP (cAMP)--a molecule found in every cell in our bodies--was elevated in nerve cells, the blockers of growth did not inhibit regeneration. The drug Rolipram blocks an enzyme--phosphodiesterase (PDE)--that breaks down cAMP, thus inhibiting PDE , which leads to an accumulation of cAMP and nerve regrowth.

To treat seven female rats injured on one side of their spinal cords at th
'"/>

Contact: Leah Ariniello
dawn@sfn.org
202-462-6688
Society for Neuroscience
26-Oct-2004


Page: 1 2 3 4 5

Related medicine news :

1. Several commonly used pesticides are toxic to mitochondria in laboratory experiments
2. Fixing of the lumbar column aided by simple radiological techniques
3. Acting techniques may help doctors empathize with their patients
4. Cartilage repair techniques shown to restore patient mobility and reduce pain
5. Molecular tailoring of chemotherapy with novel imaging techniques
6. Limitations of current evaluation techniques for the cost-effectiveness of treatments
7. New hope for ALS seen with genetic techniques, growth factors
8. Modifications to body contouring techniques for post-bariatric patients
9. Virtual colonoscopy techniques and training need to be improved before widespread clinical use
10. Manual techniques may ease tough deliveries without need for episiotomy
11. Irvine chemist wins national award for new drug techniques

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:1/20/2017)... ... 20, 2017 , ... “The Angel”: a heartwarming and earnest tale of ... of his children. “The Angel” is the creation of published author, Marjorie Lund-Fontaine, a ... and impassioned writer. , When asked of her new book, Marjorie says, “‘The Angel’ ...
(Date:1/20/2017)... ... ... a fine examination of how God handles sin, including how to let go of ... who, for over ten long years has been waiting to release this powerful insight about ... has been serving the Lord for over twenty years, and he has been preaching and ...
(Date:1/20/2017)... ... ... “Christmas in Suffolk”: a story of love, secrets, and mystery. “Christmas ... Indiana where she works in a daycare and looks for inspiration in the local ... Faith Publishing, Sara Seymour’s new book is an adventure of love and secrets. ...
(Date:1/20/2017)... ... ... “Knowledge is God’s Lighthouse”: a moving and colorful collection of prayers ... creation of published author, Gene Gaapf, a retired truck driver, and a long-time writer, ... writing since high school and have many different titles,” Gaapf mentions about his different ...
(Date:1/20/2017)... ... , ... “God's Miracle Man: Against All Odds”: an inspiring affirmation of ... Keith C. A. Tucker, son of Minister Delores Pinnock and a Jamaican native who ... Hardy , “While sitting up in bed, I felt a pounding headache. It was ...
Breaking Medicine News(10 mins):
(Date:1/20/2017)... , Jan. 20, 2017 Wells Specialty Pharmacy announces ... Howell Branch Rd in Winter Park, Florida ... Park . Operations have been consolidated into the 3796 ... also pleased to announce that Chad Tomlinson , former ... the Company effective immediately. Mr. Tomlinson is a Graduate of ...
(Date:1/20/2017)... , January 20, 2017 Avillion LLP, a ... of Mark Weinberg , MD MBA as Chief Medical Officer. ... USA . ... Dr Weinberg has spent more than 17 years as ... pharma companies to micro-cap biotech. Over the course of his career, ...
(Date:1/19/2017)... Jan. 19, 2017 The global immunomodulators ... by 2025, according to a new study by ... to be predominantly driven by high R&D investments ... large-scale production of new and therapeutically advanced drugs. ... drugs at an unprecedented rate into the immunomodulators ...
Breaking Medicine Technology:
Cached News: