The study of 16 young men who were habitual spit tobacco users measured their responses 30 minutes after dipping snuff. These readings were compared with measurements from another session involving the same participants after they had used a placebo product that was similar in taste, color and texture but did not contain tobacco or nicotine. The study was randomized and double-blinded; neither the researchers nor the subjects were told when they were taking the placebo and when they were using the tobacco product.
After snuff use, heart rate increased by about 15 beats per minute (25 percent), systolic blood pressure went up by 12 mmHg (10 percent), and measurements of adrenalin in the bloodstream increased by more than 50 percent.
"These results suggest a very significant excitatory effect of substances contained in spit tobacco on the part of the nervous system regulating the heart and blood vessels," says Virend Somers, M.D., Ph.D., the Mayo Clinic cardiologist who led the study. "Although we did anticipate some increase in blood pressure, we were surprised at the magnitude of the increase, as well as the very striking increases in heart rate and plasma epinephrine, or adrenalin. We anticipated that since these individuals were young and healthy and were accustomed to using spit tobacco, that any responses that we measured would be blunted. This makes the degree of increases even more noteworthy."
Robert Wolk, M.D., Ph.D., lead author on this study, noted that these results have implications both for long-term users and for individuals with established heart disease.
"The degree of speeding up of heart rate and increase in blood pressure, as well the increase in adrenalin (epinephrine) levels, suggest that if similar changes occur in people with established heart disease, who use spit tobacco, there may be reason to expect adverse consequences," Dr. Wolk says.
"Dipping" is Rising
More than five million adultsPage: 1 2 3 Related medicine news :1
Contact: Lisa Lucier
. Short-term increase in ozone linked to rise in number of deaths in large US cities2
. Short-term dyslexia treatment strengthens key brain regions3
. Short-term pain can mean long-term gain for osteoarthritis patients4
. Brain activity prior to treatment flags vulnerability to antidepressant side effects5
. Storage time and temperature effects nutrients in spinach6
. NASA awards $9.8 million NSCOR grant to UT Southwestern to study effects of space radiation exposure7
. Investigational transplant drug effectively preserves kidneys while avoiding toxic side effects8
. Alcohols damaging effects on adolescent brain function9
. Uric acid may help reduce effects of spinal cord injury, Jefferson researchers find10
. Methamphtetamines ruinous effects on children documented in Midwest study11
. Common antidepressants lower effects of tamoxifen in many women