HOME >> MEDICINE >> NEWS
Sildenafil effectively treats enlarged hearts, mouse study shows

Researchers at Johns Hopkins have found that sildenafil citrate (Viagra), a drug used to treat erectile dysfunction (ED) in millions of men, effectively treats enlarged hearts in mice, stopping further muscle growth from occurring and reversing existing growth, including the cellular and functional damage it created.

"A larger-than-normal heart is a serious medical condition, known as hypertrophy, and is a common feature of heart failure that can be fatal," says study senior author and cardiologist David Kass, M.D., a professor at The Johns Hopkins University School of Medicine and its Heart Institute. Kass is also the Abraham and Virginia Weiss Professor of Cardiology at Hopkins.

Sildenafil, Kass says, was the focus of his research because it blocks or stops an enzyme, called phosphodiesterase 5 (PDE5A), involved in the breakdown of a key molecule, cyclic GMP, which serves as a "natural brake" to stresses and overgrowth in the heart. "We thought we could more strongly apply the brake on hypertrophy in the heart if we used sildenafil to prevent the breakdown of cyclic GMP," he says. The makers of the drug had no involvement in the design or support of the research. PDE5A is also the biological pathway blocked in the penis to prevent the relaxation of blood vessels and maintain erections.

The Johns Hopkins findings, to be published in the journal Nature Medicine online Jan. 23, are the first to show that sildenafil is an effective treatment for a chronic heart condition. It is also the first study to reveal that the enzyme pathway blocked by sildenafil (PDE5A), never before known to play a significant role in the heart, is active when the heart is exposed to pressure stress and hypertrophied. The results provide some of the strongest evidence to date that blocking the heart's adaptive response to hypertrophy does not harm its function but, in fact, may improve it, Kass says. Already, plans are under way by the Hopkins researchers f
'"/>

Contact: David March
dmarch1@jhmi.edu
410-955-1534
Johns Hopkins Medical Institutions
23-Jan-2005


Page: 1 2 3 4

Related medicine news :

1. Meta-Analysis Of The Efficacy Of Sildenafil (ViagraTM) In The Treatment Of Severe Erectile Dysfunction
2. Effect Of Sildenafil (ViagraTM) On Quality Of Life Parameters In Men With Broad-Spectrum Erectile Dysfunction
3. Genetic amplification (NAAT) test detects HIV more effectively than standard tests in urban study
4. Investigational transplant drug effectively preserves kidneys while avoiding toxic side effects
5. Stem cell therapy effectively treats heart attacks in animals
6. Laparoscopic gastric bypass surgery effectively improves obesity-related health problems
7. Blueberry compound shows promise of lowering cholesterol as effectively as drug
8. Placebo study indicates lower doses may effectively treat ADHD
9. Enzyme replacement therapy found to effectively treat patients with Fabry disease
10. Doctors use novel methods to more effectively treat lung cancer
11. Combinaton of radiation and hormone suppression therapy shown to effectively treat early-stage prostate cancer

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/11/2020)... ... August 11, 2020 , ... The Organic Alcohol Company ... line of sanitizers that are fragrance-free and gentle on the hands using top ... or potentially dangerous levels of toxic chemicals. This is another reason The Organic ...
(Date:8/7/2020)... ... 2020 , ... Belle Meade Family Dentistry, a full-service family ... with no referral necessary. This will make it easier for those patients to ... This advantage is especially crucial during the COVID-19 pandemic because it allows them ...
(Date:8/5/2020)... ... August 05, 2020 , ... ... (SEL) program, has been named to the inaugural list of Best Digital Tools ... , This recognition honors electronic resources that provide enhanced learning and curriculum development ...
(Date:8/5/2020)... ... August 05, 2020 , ... ChronWell, ... Cruger as Director of Clinical Services and Myron Falchuk, M.D. as an Advisor, ... , “ChronWell has achieved incredible growth as demand for remote care management services ...
(Date:8/5/2020)... ... 04, 2020 , ... MemoryCare.com , a comprehensive resource ... Memory Care Facilities in Austin, Texas. The guide identifies 14 memory care communities ... to the Alzheimer’s Association , 5.6 million people aged 65 and older ...
Breaking Medicine News(10 mins):
(Date:8/5/2020)... ... August 04, 2020 , ... Help.org , a trusted ... the Best Rehab Facilities in Akron, Ohio for 2020. The informational guide recognizes the ... , According to recent studies , drug overdose is the leading cause ...
(Date:8/5/2020)... ... August 04, 2020 , ... ... therapy services vital to their health and quality of life unless Congress and ... American Speech-Language-Hearing Association (ASHA) warns today. , At issue is ...
(Date:8/3/2020)... , ... August 03, 2020 , ... ... an agreement has been reached, to amend and restate IDRI’s license with Immune ... United States and Canada). Under the amendment, the parties have agreed to modify ...
Breaking Medicine Technology:
Cached News: