'Silent' HIV Infection Lasts A Lifetime

Hopkins Physicians Urge Patients To Keep Taking Anti-HIV Medication

In 1995, researchers at Johns Hopkins discovered HIV (human immunodeficiency virus) evades anti-viral drugs by hiding in the immune system, infecting certain white blood cells, called T cells, and then going to sleep, or turning off. In the May Nature Medicine, the same team reports this silent infection persists for a lifetime.

"This doesn't mean a cure for HIV is impossible, but it is an obstacle," says Robert Siliciano, M.D., Ph.D., senior author on the report. "And it emphasizes that patients need to stay on their medication, possibly for the rest of their lives."

However, not all news from the study was bleak. The study patients, who kept to their strict drug regimens under supervision from physicians at the Johns Hopkins Moore HIV Clinic, all had undetectable levels of HIV in their blood and no signs of AIDS (acquired immune deficiency syndrome).

"The good news is that patients who comply with their therapy are able to keep the virus suppressed for long periods," says Joel Gallant, M.D., who directs the Moore Clinic. "We have assumed that therapy for HIV patients would have to be long-term or even lifelong. This study suggests that is still the case. But the study also suggests that HIV-infected patients can still live long, healthy lives without symptoms, provided they are rigorous about taking their medications." When taken as prescribed, combination therapy (the so-called "drug cocktails") of older anti-HIV drugs like AZT and newer protease inhibitors (PIs) or non-nucleoside reverse transcriptase inhibitors (NNRTIs), reduces the amount of circulating virus to undetectable levels in most patients. The immune system remains relatively healthy and the collection of diseases that signal AIDS is staved off.

But the latent form of HIV can wait out even decades of anti-HIV therapy. First, it integrates its genetic code

Contact: Brian Vastag
Johns Hopkins Medical Institutions

Page: 1 2

Related medicine news :

1. Infection in breast implants
2. No advantage of combination drug therapy for chronic hepatitis B Infection
3. Infection in ELBW infants linked with poor neurodevelopmental, growth outcomes
4. Infection puts extremely low birth weight infants at risk for developmental delays
5. Infections in low-birth-weight infants are associated with impaired neurodevelopment and growth
6. Infection, not lack of oxygen, plays larger role in premature infant brain injury
7. Infections linked to mental decline in elderly
8. Infection with toxoplasmososis increases the risk of being involved in a road traffic accident
9. Holding Policy Is Cost-Effective Way To Further Protect Blood Plasma Supply From HIV And Other Infections
10. New Contact Lens Material Could Lessen Risk Of Eye Infection
11. Study Offers Hope For Immune Reconstitution After HIV Infection

Post Your Comments:

(Date:8/31/2020)... ... August 31, 2020 , ... ... management solution for chiropractors, announced today the launch of its integrated, HIPAA compliant, ... start running their virtual practice in under 90 seconds. , According to ...
(Date:8/31/2020)... IRVINE, Calif. (PRWEB) , ... August 31, 2020 ... ... providers of business support services to dental groups in the United States, today ... serving the community of Beaumont, CA. , Patients will enjoy convenient hours, ...
(Date:8/31/2020)... ... 31, 2020 , ... A Cure for Covid-19 “PTS” with Mediation & Hypnosis , At ... a state of panic, experiencing deep anxiety, immense stress, and right now are needing serious ... when most people on the planet are experiencing a great degree of emotional discomfort, be ...
(Date:8/31/2020)... PASADENA, Calif. (PRWEB) , ... August 31, 2020 ... ... and leadership experience working, both directly with persons with autism and other developmental ... clinical expertise includes early intervention, parent education, adolescents with autism, school consultation, and ...
(Date:8/29/2020)... ... ... When professor and author Randy Pausch was diagnosed with pancreatic cancer, he accepted ... melancholic, however, he put together a final lecture in Carnegie Hall in which he ... situation and turned it into something that inspired millions of people worldwide. This inclination ...
Breaking Medicine News(10 mins):
(Date:9/2/2020)... ... September 02, 2020 , ... Rigaku Analytical ... roundtable discussion among industry professionals about successes and challenges of making changes to ... Pharmaceutical Review and will take place on October 15, 2020 at 10:00am ...
(Date:9/1/2020)... (PRWEB) , ... September 01, 2020 , ... ... and Director of Cosmetics and Laser Surgery at the University of Rochester Medical ... Surgery fellowship at SkinCare Physicians in Boston, with clinical faculty from the Harvard ...
(Date:9/1/2020)... ... 2020 , ... September is National Ovarian Cancer Awareness Month. Ovarian cancer ... cancer of the female reproductive system. The American Cancer Society estimates that in ... will die from this disease. Throughout the month of September, Women’s Excellence aims ...
Breaking Medicine Technology:
Cached News: