HOME >> MEDICINE >> NEWS
Small molecule found to mimic key nerve growth factors; May eventually be used in treatment of brain disorders

Washington, DC--Scientists have found that a small, naturally-occurring molecule that enters the brain easily keeps nerve cells alive by stimulating the actions of growth factors. This points the way for the potential use in the future of small molecules to approach a number of disorders, which may include Alzheimers disease, spinal cord injury and Lou Gehrigs disease.

We have discovered that a small molecule called adenosine can mimic the effects of nerve growth factor and brain-derived growth factor to prevent cell death in the nervous system, says Moses Chao, PhD, a neurobiologist at New York University. Such growth factors serve as survival agents for nerve cells, keeping them alive. Chaos study, funded primarily by the National Institutes of Health, appears in the March 13 issue of The Proceedings of the National Academy of Sciences. This is important because although there are many potential uses for growth factors for treatment of diseases, they are difficult to deliver. In contrast, small molecules such as adenosine are easy to deliver, says Lloyd Greene, PhD, a neuroscientist and professor of pathology at Columbia University.

Using rat nerve cells isolated from the hippocampus, a brain area involved in learning and memory, and grown in the laboratory, Chao found that adenosine was able to communicate with receptors for brain-derived growth factor. This resulted in the production of the signals that prevented neurons from dying.

These results suggest that there may be other small molecules that work like adenosine. The next steps are to test adenosine compounds in animal models of human diseases.


'"/>

Contact: Joe Carey
joe@sfn.org
202-745-5138
Society for Neuroscience
5-Mar-2001


Page: 1

Related medicine news :

1. Small increases or blips in HIV levels do not signal mutations leading to drug-resistant HIV
2. Rices CNST awards Smalley/Curl funds for innovation
3. Small steps toward coverage
4. Small band of nurses plays key role keeping germ threats at bay
5. Small social circles tied to heart disease death in women
6. Small study shows SAMe may improve treatment of depression
7. South Floridas Small wins The Gerontological Society of Americas 2004 Margret M. Baltes Award
8. Smallpox vaccine can be diluted and still be effective, expanding supply if needed
9. Small, frequent doses of caffeine best strategy for staying awake
10. New study: Small, frequent doses of caffeine best strategy for staying awake
11. Small uterine fibroids may be linked with increased risk of miscarriage, early study results show

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/17/2017)... ... February 17, 2017 , ... The ... systems change designed to further positively impact the health and wellness of our ... long considered it our duty to seriously consider releasing our assets beyond our ...
(Date:2/17/2017)... ... February 17, 2017 , ... ... Feb. 22, 2017 — 1:30 p.m. – 2:30 p.m. ET, http://www.fdanews.com/deviceapproval ... asking before selecting an FDA approval pathway? , How should they evaluate ...
(Date:2/17/2017)... Seattle, WA (PRWEB) , ... February 17, 2017 ... ... health management organizations, has been named a finalist in the 8th Annual DecisionHealth ... impacting America's healthcare delivery system. Qualis Health’s work is recognized across multiple award ...
(Date:2/17/2017)... ... February 17, 2017 , ... ... announced today that Karen Pilley has been promoted to Chief Executive Officer. ... shifting healthcare paradigm – a shift that demands the transition from pay-for-service to ...
(Date:2/17/2017)... ... February 17, 2017 , ... Cancer ... Molecular Medicine Tri-Conference February 20 – 22 in San Francisco. As part of ... anatomic and molecular pathology workflow solution, as well as its new precision medicine ...
Breaking Medicine News(10 mins):
(Date:2/17/2017)... and Markets has announced the addition of the "Pharmaceutical Contract Manufacturing ... ... the US, Canada , Japan , ... of World. Annual estimates and forecasts are provided for the period 2015 ... Market data and analytics are derived from primary and secondary research. ...
(Date:2/17/2017)... Feb. 17, 2017   FormFast , the leader ... new partnership with Engage , one of the ... . FormFast will serve as the forms automation ... with MEDITECH .  FormFast is ... to complement and enhance the electronic health record. FormFast,s ...
(Date:2/17/2017)... -- Noble Capital Markets announced today that it has initiated ... EPIX ). The report was issued by Noble,s Head ... ESSA Pharmaceuticals is a clinical stage biopharmaceutical company ... lead compound EPI-506, is a small molecule oral drug ... receptor, thereby has potential to overcome some of the ...
Breaking Medicine Technology:
Cached News: