HOME >> MEDICINE >> NEWS
Small molecule found to mimic key nerve growth factors; May eventually be used in treatment of brain disorders

Washington, DC--Scientists have found that a small, naturally-occurring molecule that enters the brain easily keeps nerve cells alive by stimulating the actions of growth factors. This points the way for the potential use in the future of small molecules to approach a number of disorders, which may include Alzheimers disease, spinal cord injury and Lou Gehrigs disease.

We have discovered that a small molecule called adenosine can mimic the effects of nerve growth factor and brain-derived growth factor to prevent cell death in the nervous system, says Moses Chao, PhD, a neurobiologist at New York University. Such growth factors serve as survival agents for nerve cells, keeping them alive. Chaos study, funded primarily by the National Institutes of Health, appears in the March 13 issue of The Proceedings of the National Academy of Sciences. This is important because although there are many potential uses for growth factors for treatment of diseases, they are difficult to deliver. In contrast, small molecules such as adenosine are easy to deliver, says Lloyd Greene, PhD, a neuroscientist and professor of pathology at Columbia University.

Using rat nerve cells isolated from the hippocampus, a brain area involved in learning and memory, and grown in the laboratory, Chao found that adenosine was able to communicate with receptors for brain-derived growth factor. This resulted in the production of the signals that prevented neurons from dying.

These results suggest that there may be other small molecules that work like adenosine. The next steps are to test adenosine compounds in animal models of human diseases.


'"/>

Contact: Joe Carey
joe@sfn.org
202-745-5138
Society for Neuroscience
5-Mar-2001


Page: 1

Related medicine news :

1. Small increases or blips in HIV levels do not signal mutations leading to drug-resistant HIV
2. Rices CNST awards Smalley/Curl funds for innovation
3. Small steps toward coverage
4. Small band of nurses plays key role keeping germ threats at bay
5. Small social circles tied to heart disease death in women
6. Small study shows SAMe may improve treatment of depression
7. South Floridas Small wins The Gerontological Society of Americas 2004 Margret M. Baltes Award
8. Smallpox vaccine can be diluted and still be effective, expanding supply if needed
9. Small, frequent doses of caffeine best strategy for staying awake
10. New study: Small, frequent doses of caffeine best strategy for staying awake
11. Small uterine fibroids may be linked with increased risk of miscarriage, early study results show

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/25/2017)... (PRWEB) , ... April 25, ... ... based in Newport Beach, California, committed to raising awareness for Duchenne muscular ... results from its randomized CAP-1002 (cardiosphere-derived cells) Phase I/II HOPE clinical trial ...
(Date:4/25/2017)... ... April 25, 2017 , ... Lake Park Dental is ... using Invisalign® in Lutz, FL. With the help of this highly-effective, yet ... with fewer potential complications, more discretion and less pain. , Drs. Sarah Jockin, ...
(Date:4/25/2017)... MN (PRWEB) , ... April 25, 2017 , ... Buyers ... and recreational users to dispensaries and head shops –can’t help but be heartened by ... for the tell-tale cannabis odor aptly described as “skunk smell.” At last they ...
(Date:4/25/2017)... ... April 25, 2017 , ... Vetoquinol USA® , a ... UCII, part of the EQUISTRO line, at this week’s Rolex Kentucky Three-Day Event ... the immunologic level. , The scientifically-developed Flexadin UCII supports the body’s normal repair ...
(Date:4/24/2017)... ... April 24, 2017 , ... The Santana Telehealth Project was honored with the ... the American Telemedicine Association’s annual conference, on April 23 in Orlando, FL. , “I ... improve the lives of the poor and underserved in other parts of the world,” ...
Breaking Medicine News(10 mins):
(Date:4/19/2017)... 2017  IRIDEX Corporation (Nasdaq: IRIX ) ... the first quarter 2017 after the close of trading ... will host a corresponding conference call beginning at 2:30 ... interested in listening to the conference call may do ... (703) 326-3030 for international callers, using conference ID: 92158987.  ...
(Date:4/19/2017)... DIEGO , April 19, 2017  Sorrento ... an antibody-centric, clinical-stage biopharmaceutical company developing new treatments ... announced the closing of its previously announced underwritten ... stock at a public offering price of $2.00 ... and estimated offering expenses payable by Sorrento.  The ...
(Date:4/18/2017)... April 18, 2017  Cardinal Health (NYSE: ... fiscal 2017 earnings per share (EPS) guidance and providing ... is in conjunction with this morning,s announcement of the ... and Nutritional Insufficiency businesses. Cardinal Health now ... will be at the bottom of its previous guidance ...
Breaking Medicine Technology:
Cached News: