HOME >> MEDICINE >> NEWS
Small molecule found to mimic key nerve growth factors; May eventually be used in treatment of brain disorders

Washington, DC--Scientists have found that a small, naturally-occurring molecule that enters the brain easily keeps nerve cells alive by stimulating the actions of growth factors. This points the way for the potential use in the future of small molecules to approach a number of disorders, which may include Alzheimers disease, spinal cord injury and Lou Gehrigs disease.

We have discovered that a small molecule called adenosine can mimic the effects of nerve growth factor and brain-derived growth factor to prevent cell death in the nervous system, says Moses Chao, PhD, a neurobiologist at New York University. Such growth factors serve as survival agents for nerve cells, keeping them alive. Chaos study, funded primarily by the National Institutes of Health, appears in the March 13 issue of The Proceedings of the National Academy of Sciences. This is important because although there are many potential uses for growth factors for treatment of diseases, they are difficult to deliver. In contrast, small molecules such as adenosine are easy to deliver, says Lloyd Greene, PhD, a neuroscientist and professor of pathology at Columbia University.

Using rat nerve cells isolated from the hippocampus, a brain area involved in learning and memory, and grown in the laboratory, Chao found that adenosine was able to communicate with receptors for brain-derived growth factor. This resulted in the production of the signals that prevented neurons from dying.

These results suggest that there may be other small molecules that work like adenosine. The next steps are to test adenosine compounds in animal models of human diseases.


'"/>

Contact: Joe Carey
joe@sfn.org
202-745-5138
Society for Neuroscience
5-Mar-2001


Page: 1

Related medicine news :

1. Small increases or blips in HIV levels do not signal mutations leading to drug-resistant HIV
2. Rices CNST awards Smalley/Curl funds for innovation
3. Small steps toward coverage
4. Small band of nurses plays key role keeping germ threats at bay
5. Small social circles tied to heart disease death in women
6. Small study shows SAMe may improve treatment of depression
7. South Floridas Small wins The Gerontological Society of Americas 2004 Margret M. Baltes Award
8. Smallpox vaccine can be diluted and still be effective, expanding supply if needed
9. Small, frequent doses of caffeine best strategy for staying awake
10. New study: Small, frequent doses of caffeine best strategy for staying awake
11. Small uterine fibroids may be linked with increased risk of miscarriage, early study results show

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/26/2016)... LINCOLN, R.I. (PRWEB) , ... May 26, 2016 , ... ... season. That’s why Amica Insurance is sharing tips to make sure your ... an estimate from the National Safety Council, there may be 439 deaths and an ...
(Date:5/26/2016)... ... May 26, 2016 , ... The Lung Institute has partnered ... cessation class starting June 6 at their clinic in downtown Tampa. The class is ... the Lung Institute has created a free downloadable 4 Week Smoking Cessation Guide ...
(Date:5/26/2016)... ... May 26, 2016 , ... ... Orthopedics and chief medical officer of Blue Horizon International (BHI), Brian Mehling, M.D., ... conference was held during May 5-6, 2016 in Chicago, IL, USA. Dr. Mehling’s ...
(Date:5/26/2016)... ... May 26, 2016 , ... Power Systems, a leading ... PowerWave Instructor Certification Course in Stoughton, Massachusetts. The course was led by Power ... the 8 hour interactive course to qualify participants as certified PowerWave trainers. ...
(Date:5/26/2016)... , ... May 26, 2016 , ... On May 23rd ... Research Water Life Science® and international water advocate, was honored by Ashram, Inc. as ... in ancient Egypt who knelt on the banks of the Nile to fill their ...
Breaking Medicine News(10 mins):
(Date:5/24/2016)... May 24, 2016   ... beide primären Endpunkte und demonstriert Ebenbürtigkeit ... ‚ausgezeichneter plus guter , ... ,      (Logo: http://photos.prnewswire.com/prnh/20130829/633895-a ... neue positive Daten von der MORA-Studie der Phase ...
(Date:5/24/2016)... New Zealand , May 24, 2016 ... and informatics solutions for the healthcare sector, has been named ... New Zealand Hi-Tech Awards 2016. Dr Bruce ... fantastic acknowledgement for our team.  It,s really good to be ... burden healthcare internationally. Our products are used in 35 countries ...
(Date:5/24/2016)... VMS BioMarketing as senior vice president of sales, announced Andrea Heslin Smiley , ... the company,s business development and sales team, exploring new opportunities for VMS to empower ... ... ... ...
Breaking Medicine Technology:
Cached News: