HOME >> MEDICINE >> NEWS
Smoking and the risk of rheumatoid arthritis

This press release is also available in Swedish.

Rheumatoid arthritis (RA), like many chronic diseases of the immune system, likely results from a combination of genetic susceptibility and environmental triggers. Recently, a team of researchers in Sweden set out to investigate the interaction of two specific risk factors: the presence of a gene encoding protein sequence called the shared epitope (SE), the major genetic risk factor so far defined for RA, and cigarette smoking. The results, published in the October 2004 issue of Arthritis & Rheumatism (http://www.interscience.wiley.com/journal/arthritis), indicate that smoking significantly increases the risk of RA among men and women with a genetic predisposition for the disease.

Conducted by a research team in Sweden, this population-based study focused on a large sample of patients with a confirmed diagnosis of the disease--858 individuals, 612 women and 246 men, with an average age of 49 years. The researchers also recruited 1,048 healthy individuals to serve as controls. Participants donated blood samples for DNA genotyping. Every participant also completed lifestyle questionnaires, including smoking habits. Since former smokers tend to have a wide variation in their cumulative smoking history, the researchers chose to restrict their analysis to current smokers and men and women who had never smoked.

The DNA samples of the RA patients were studied for evidence of genes for the SE. The SE is a protein sequence found in cell surface molecules that regulate specific immune responses. The blood samples were also tested for rheumatoid factor, a hallmark of this disease. Then, analyzing women and men together, the researchers compared current smokers with never smokers for the risk of rheumatoid factor positive RA. For people with the SE gene who never smok
'"/>

Contact: Sabina Bossi
sabina.bossi@admin.ki.se
46-8-524-838-95
Swedish Research Council
8-Oct-2004


Page: 1 2

Related medicine news :

1. Smoking hurts wealth as well as health, study suggests
2. Smoking causes cognitive impairment in adolescents
3. Smoking not linked to hearing loss
4. Smoking triggers early onset of pancreatic cancer
5. Smoking cessation can improve survival among patients with severe COPD
6. Smoking increases risk of colon polyps
7. Smoking affects same feel good brain chemical system as heroin
8. Smoking increases papillomavirus risk in HIV-infected women
9. Smoking linked to more than 60 percent of overall cancer death burden in black men
10. Smoking linked to accelerated cognitive decline in the elderly
11. Smoking linked to blindness

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:7/18/2019)... ... July 18, 2019 , ... ... officials in Congress about new bills to protect patients from unexpected out-of-network medical ... People from Surprise Medical Bills Act ( H.R. 3502 ), introduced in the ...
(Date:7/18/2019)... ... July 18, 2019 , ... For the fourth ... Atlanta, Magazine’s list of “Top Doctors” issue. Deutsch is a double-board-certified plastic and, ... With specialized training from MD Anderson Cancer Center and Albert Einstein, Montefiore Medical ...
(Date:7/18/2019)... ... July 18, 2019 , ... Gateway Genomics , ... announces a new publication titled, “ Accurate Fetal Sex Determination from Maternal Blood at ... the study, DNA blood samples were collected from 108 women at an average gestational ...
(Date:7/17/2019)... PORTLAND, Ore. (PRWEB) , ... July 17, 2019 , ... ... way, at which damage to the teeth could occur, from the accident scene, to ... done before and created a paradigm shift for treatment. , They identified seven points, ...
(Date:7/17/2019)... , ... July 17, 2019 , ... ... and administrators of critical access hospitals. , The men and women included on ... overseen hospital expansions, mergers and EHR implementations as well as the construction of ...
Breaking Medicine News(10 mins):
(Date:7/17/2019)... ... July 17, 2019 , ... ... MDA for their fourth annual national “Be Their Muscle” philanthropic event, and seventh ... lives of kids and adults with muscular dystrophy, ALS and related neuromuscular diseases ...
(Date:7/17/2019)... , ... July 17, 2019 , ... SmartLinx, a leader ... SmartLinx Go, that further engages healthcare employees by enabling them to take control of ... point to show up to work and do more work -- highly engaged business ...
(Date:7/17/2019)... ... July 17, 2019 , ... Argos Risk, an industry ... the healthcare sector during the second quarter of 2019. Three nationwide companies, whose ... join a strong client list in managing and mitigating third-party risk. , “We ...
Breaking Medicine Technology:
Cached News: