HOME >> MEDICINE >> NEWS
Some breast cancer patients may benefit from endocrine therapy alone

SAN ANTONIO -- The estrogen receptor status of breast cancer may help to predict which patients will benefit from chemotherapy treatment, say researchers at The University of Texas M. D. Anderson Cancer Center.

Their study, presented at the San Antonio Breast Cancer Symposium, could change the way breast cancer is treated in the future. Now, patients routinely receive chemotherapy as their first treatment, followed by surgery. Patients with estrogen-positive tumors --tumors that use estrogen to fuel their growth -- may then receive endocrine therapies that block the estrogen action or production, or interfere with the hormonal pathways.

This study suggests patients with estrogen-positive cancer may benefit more from an initial treatment of endocrine therapies rather than chemotherapy.

"We hope this study will help to direct the best treatment for patients," says the study's author, Aman Buzdar, M.D., professor in the Department of Breast Medical Oncology at M. D. Anderson. "In the future, we may be able to identify patients who will do well with endocrine therapies alone."

Buzdar and a team of researchers looked at tumor samples of 1,018 patients followed at the center since 1975 in which the estrogen receptor status was known. All patients received chemotherapy and surgery.

The investigators looked for the evidence of a complete "pathological response" to treatment (there was no invasive cancer left either in the breast or in the lymph nodes), and separated the results by estrogen receptor status. They found that more than 20 percent of patients with estrogen-negative breast cancer had a complete pathologic response compared with five percent in estrogen-positive cancer.

"It didn't matter what kind of chemotherapy was used, there was more benefit observed in patients with estrogen receptor-negative cancers," says Buzdar. "Even though a significant number of estrogen-positive patients had clinical regression in thei
'"/>


4-Dec-2003


Page: 1 2

Related medicine news :

1. International breast cancer prevention study launches in the United States and Canada
2. Unexpected benefit seen in treating HER-2 breast cancer with new preoperative drug combo
3. Risk of cardiac death after radiotherapy for breast cancer has declined, study finds
4. Study shows risk of cardiac death after radiation for breast cancer has dramatically decreased
5. Study shows acrylamide in baked and fried food does not increase risk of breast cancer in women
6. Researchers say breast cancer in Africa may provide clues to the disease in African-Americans
7. Postmenopausal breast cancer survivors at increased risk for bone fractures
8. Nursing mothers having surgery -- How long a wait to breastfeed safely?
9. Researchers close in on breast cancer vaccine
10. Simple question from your doctor can help identify your risk for breast cancer
11. Non-invasive and invasive breast cancers share the same genetic mutations

Post Your Comments:
(Date:10/31/2014)... (PRWEB) October 31, 2014 Energy Textiles ... gear. The new gear is now available online, and ... the benefits of Celliant infrared-active athletic gear over compression ... that another contract has been signed for Under Armour ... for the next eight years. In light of this ...
(Date:10/31/2014)... (HealthDay News) -- Obesity increases the risk of certain ... women, two new U.S. studies show. One study ... or obese increased the risk for estrogen receptor-negative and ... known this for a long time for white women, ... women," study author Esther John, a senior research scientist ...
(Date:10/31/2014)... one out of four older Americans say that either ... unwanted medical treatment, according to the latest issue of ... Aging Report ( PP&AR ), which goes on ... when they fail to honor patients, end-of-life health care ... Illness Care: Issues and Options ," features 12 articles ...
(Date:10/31/2014)... October 31, 2014 The Suspension Revolution ... workout program was developed by Dan Long, a suspension ... as a fitness professional and life coach. The author ... having toned muscles is not impossible , The Suspension ... suspension training. Suspension training promises efficiency when it comes ...
(Date:10/31/2014)... a drug combination that can trigger the self-destruct process ... new treatments, according to research that will be presented ... in Liverpool next week*. , When healthy cells are ... culminating in self destruction. But cancer cells swerve away ... that cells grow out of control – causing tumours ...
Breaking Medicine News(10 mins):Health News:Compression Gear--Is There a Better Alternative? 2Health News:Compression Gear--Is There a Better Alternative? 3Health News:Compression Gear--Is There a Better Alternative? 4Health News:Study Confirms Obesity-Breast Cancer Link for Blacks, Hispanics 2Health News:Advance directives can benefit patients, families, and health care system 2Health News:Suspension Revolution Review Reveals Dan Long's New Suspension Workout Plan 2Health News:Scientists trigger self-destruct switch in lung cancer cells 2
(Date:10/31/2014)... -- Research and Markets ( ... "Process Validation in the US and EU (Workshop, ... (Logo: http://photos.prnewswire.com/prnh/20130307/600769) , ,Key topics to include:  ... Process Validation for Pharmaceutical and Biopharmaceutical Products ... Validation Guidance EU Process Validation Guideline ...
(Date:10/31/2014)...  AbbVie (NYSE: ABBV ) today ... Sept. 30, 2014. "Our third-quarter ... with double-digit growth from HUMIRA and several other ... percent in the quarter excluding lipids," said Richard ...  "We exceeded our outlook for the quarter and ...
(Date:10/30/2014)... 2014   NxStage® Kidney Care, Inc ., a subsidiary ... proud to host the grand opening ceremony of its ... 16 th Street on November 20, 2014 from 3pm ... medical staff who are committed to providing patients with enhanced ... made possible through more flexible dialysis treatment options.   ...
Breaking Medicine Technology:Process Validation in the US and EU (Workshop, London) 2Process Validation in the US and EU (Workshop, London) 3Process Validation in the US and EU (Workshop, London) 4AbbVie Reports Third-Quarter 2014 Financial Results 2AbbVie Reports Third-Quarter 2014 Financial Results 3AbbVie Reports Third-Quarter 2014 Financial Results 4AbbVie Reports Third-Quarter 2014 Financial Results 5AbbVie Reports Third-Quarter 2014 Financial Results 6AbbVie Reports Third-Quarter 2014 Financial Results 7AbbVie Reports Third-Quarter 2014 Financial Results 8AbbVie Reports Third-Quarter 2014 Financial Results 9AbbVie Reports Third-Quarter 2014 Financial Results 10AbbVie Reports Third-Quarter 2014 Financial Results 11AbbVie Reports Third-Quarter 2014 Financial Results 12AbbVie Reports Third-Quarter 2014 Financial Results 13AbbVie Reports Third-Quarter 2014 Financial Results 14AbbVie Reports Third-Quarter 2014 Financial Results 15AbbVie Reports Third-Quarter 2014 Financial Results 16AbbVie Reports Third-Quarter 2014 Financial Results 17AbbVie Reports Third-Quarter 2014 Financial Results 18AbbVie Reports Third-Quarter 2014 Financial Results 19AbbVie Reports Third-Quarter 2014 Financial Results 20AbbVie Reports Third-Quarter 2014 Financial Results 21AbbVie Reports Third-Quarter 2014 Financial Results 22AbbVie Reports Third-Quarter 2014 Financial Results 23AbbVie Reports Third-Quarter 2014 Financial Results 24Grand Opening of NxStage Kidney Care Oak Brook IL Center 2Grand Opening of NxStage Kidney Care Oak Brook IL Center 3
Cached News: