HOME >> MEDICINE >> NEWS
Some breast cancer patients may benefit from endocrine therapy alone

SAN ANTONIO -- The estrogen receptor status of breast cancer may help to predict which patients will benefit from chemotherapy treatment, say researchers at The University of Texas M. D. Anderson Cancer Center.

Their study, presented at the San Antonio Breast Cancer Symposium, could change the way breast cancer is treated in the future. Now, patients routinely receive chemotherapy as their first treatment, followed by surgery. Patients with estrogen-positive tumors --tumors that use estrogen to fuel their growth -- may then receive endocrine therapies that block the estrogen action or production, or interfere with the hormonal pathways.

This study suggests patients with estrogen-positive cancer may benefit more from an initial treatment of endocrine therapies rather than chemotherapy.

"We hope this study will help to direct the best treatment for patients," says the study's author, Aman Buzdar, M.D., professor in the Department of Breast Medical Oncology at M. D. Anderson. "In the future, we may be able to identify patients who will do well with endocrine therapies alone."

Buzdar and a team of researchers looked at tumor samples of 1,018 patients followed at the center since 1975 in which the estrogen receptor status was known. All patients received chemotherapy and surgery.

The investigators looked for the evidence of a complete "pathological response" to treatment (there was no invasive cancer left either in the breast or in the lymph nodes), and separated the results by estrogen receptor status. They found that more than 20 percent of patients with estrogen-negative breast cancer had a complete pathologic response compared with five percent in estrogen-positive cancer.

"It didn't matter what kind of chemotherapy was used, there was more benefit observed in patients with estrogen receptor-negative cancers," says Buzdar. "Even though a significant number of estrogen-positive patients had clinical regression in thei
'"/>


4-Dec-2003


Page: 1 2

Related medicine news :

1. International breast cancer prevention study launches in the United States and Canada
2. Unexpected benefit seen in treating HER-2 breast cancer with new preoperative drug combo
3. Risk of cardiac death after radiotherapy for breast cancer has declined, study finds
4. Study shows risk of cardiac death after radiation for breast cancer has dramatically decreased
5. Study shows acrylamide in baked and fried food does not increase risk of breast cancer in women
6. Researchers say breast cancer in Africa may provide clues to the disease in African-Americans
7. Postmenopausal breast cancer survivors at increased risk for bone fractures
8. Nursing mothers having surgery -- How long a wait to breastfeed safely?
9. Researchers close in on breast cancer vaccine
10. Simple question from your doctor can help identify your risk for breast cancer
11. Non-invasive and invasive breast cancers share the same genetic mutations

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:7/20/2017)... (PRWEB) , ... July 19, 2017 , ... ... “surprising habits” that may sometimes lead to, or worsen, varicose veins in some ... Center notes that, while avoiding certain not-so-good practices, like excessive sitting or standing, ...
(Date:7/18/2017)... Massachusetts (PRWEB) , ... July 18, 2017 , ... ... medical device compliance and commercialization, has just announced two more sessions of its ... usability engineering into risk management activities. Led by David Cronin, Cognition’s CEO, the ...
(Date:7/18/2017)... ... 2017 , ... An inventor from Anacortes, Wash., knows the difficulties and indignity ... hot flashes, and I suffer from anxiety and vertigo on top of that," she ... and about." INSTA-FAN meets that need. , This device enables a woman in menopause ...
(Date:7/18/2017)... ... July 18, 2017 , ... FCPX LUT Berlin for ... any media. FCPX LUT Berlin includes 60 different color-grade presets, giving FCPX users numerous ... vignettes and blurs to emphasize each subject, plus much more. FCPX LUT Berlin is ...
(Date:7/17/2017)... , ... July 17, 2017 , ... ... for parents and camp staff to ensure children are protected from Lyme and ... this year, children are at an increased risk not only for the tick-borne ...
Breaking Medicine News(10 mins):
(Date:7/1/2017)... Ind. , June 30, 2017 Zimmer Biomet ... quarter sales and earnings conference call will be broadcast live ... a.m. Eastern Time.  A news release detailing the quarterly results ... morning of the conference call. The live audio ... at http://investor.zimmerbiomet.com . It will be archived for replay ...
(Date:6/30/2017)... 30, 2017  AVACEN Medical (AVACEN) announced the publication of new ... the use of its AVACEN Treatment Method to significantly ... ... AVACEN Medical ... widespread pain. It affects approximately 200 to 400 million people worldwide according ...
(Date:6/27/2017)... , June 27, 2017  Therapix Biosciences Ltd. ... pharmaceutical company specializing in the development of cannabinoid-based drugs, ... Stock Market Opening Bell in New York, ... honor of its initial public offering (IPO) of American ... in March 2017. Dr. Elran Haber, Ph.D., ...
Breaking Medicine Technology:
Cached News: