Some breast cancer patients may benefit from endocrine therapy alone

SAN ANTONIO -- The estrogen receptor status of breast cancer may help to predict which patients will benefit from chemotherapy treatment, say researchers at The University of Texas M. D. Anderson Cancer Center.

Their study, presented at the San Antonio Breast Cancer Symposium, could change the way breast cancer is treated in the future. Now, patients routinely receive chemotherapy as their first treatment, followed by surgery. Patients with estrogen-positive tumors --tumors that use estrogen to fuel their growth -- may then receive endocrine therapies that block the estrogen action or production, or interfere with the hormonal pathways.

This study suggests patients with estrogen-positive cancer may benefit more from an initial treatment of endocrine therapies rather than chemotherapy.

"We hope this study will help to direct the best treatment for patients," says the study's author, Aman Buzdar, M.D., professor in the Department of Breast Medical Oncology at M. D. Anderson. "In the future, we may be able to identify patients who will do well with endocrine therapies alone."

Buzdar and a team of researchers looked at tumor samples of 1,018 patients followed at the center since 1975 in which the estrogen receptor status was known. All patients received chemotherapy and surgery.

The investigators looked for the evidence of a complete "pathological response" to treatment (there was no invasive cancer left either in the breast or in the lymph nodes), and separated the results by estrogen receptor status. They found that more than 20 percent of patients with estrogen-negative breast cancer had a complete pathologic response compared with five percent in estrogen-positive cancer.

"It didn't matter what kind of chemotherapy was used, there was more benefit observed in patients with estrogen receptor-negative cancers," says Buzdar. "Even though a significant number of estrogen-positive patients had clinical regression in thei


Page: 1 2

Related medicine news :

1. International breast cancer prevention study launches in the United States and Canada
2. Unexpected benefit seen in treating HER-2 breast cancer with new preoperative drug combo
3. Risk of cardiac death after radiotherapy for breast cancer has declined, study finds
4. Study shows risk of cardiac death after radiation for breast cancer has dramatically decreased
5. Study shows acrylamide in baked and fried food does not increase risk of breast cancer in women
6. Researchers say breast cancer in Africa may provide clues to the disease in African-Americans
7. Postmenopausal breast cancer survivors at increased risk for bone fractures
8. Nursing mothers having surgery -- How long a wait to breastfeed safely?
9. Researchers close in on breast cancer vaccine
10. Simple question from your doctor can help identify your risk for breast cancer
11. Non-invasive and invasive breast cancers share the same genetic mutations

Post Your Comments:

(Date:6/27/2016)... , ... June 27, 2016 , ... ... mental health professionals, announced today its affiliation with Tennessee Counseling Association. ... to the network of the Tennessee Counseling Association, adding exclusive benefits and promotional ...
(Date:6/26/2016)... (PRWEB) , ... June 26, 2016 , ... On June ... sponsor of the 2016 Cereal Festival and World’s Longest Breakfast Table in Battle Creek, ... of the city’s history as home to some of the world’s leading providers of ...
(Date:6/25/2016)... ... June 25, 2016 , ... ... issues and applications at AcademyHealth’s Annual Research Meeting June 26-28, 2016, at the ... several important health care topics including advance care planning, healthcare costs and patient ...
(Date:6/25/2016)... ... June 25, 2016 , ... As a lifelong Southern ... Laude and his M.D from the David Geffen School of Medicine at UCLA. He ... Los Angeles to complete his fellowship in hematology/oncology at the UCLA-Olive View-Cedars Sinai program ...
(Date:6/24/2016)... (PRWEB) , ... June 24, 2016 , ... Those who ... with these feelings, many turn to unhealthy avenues, such as drug or alcohol abuse, ... Marne, Michigan, has released tools for healthy coping following a traumatic event. , Trauma ...
Breaking Medicine News(10 mins):
(Date:6/26/2016)... , June 26, 2016 ... value-based care operating models within the health care industry ... greater financial efficiency , Deloitte offers a suite ... key business issues impacting efficient cost optimization: labor resource ... , These services facilitate better outcomes and better economics ...
(Date:6/24/2016)... 24, 2016   Bay Area Lyme Foundation ... Dean Center for Tick Borne Illness , Harvard ... MIT Hacking Medicine, University of California, Berkeley, and ... the five finalists of Lyme Innovation , ... than 100 scientists, clinicians, researchers, entrepreneurs, and investors ...
(Date:6/24/2016)... -- Dehaier Medical Systems Ltd. (NASDAQ: DHRM ... sells medical devices and wearable sleep respiratory products in ... agreement with Hongyuan Supply Chain Management Co., Ltd. (hereinafter ... 2016, to develop Dehaier,s new Internet medical technology business. ... leverage Hongyuan Supply Chain,s sales platform to reach Dehaier,s ...
Breaking Medicine Technology:
Cached News: