Some harms of beta-carotene supplementation may persist after discontinuing use

A 6-year follow-up of a large, randomized trial in people with a history of smoking has found that the overall harm associated with beta-carotene supplementation on cardiovascular disease mortality disappeared quickly after participants stopped taking the supplements. However, the risk of lung cancer may persist, especially in females and former smokers, according to the study in the December 1 issue of the Journal of the National Cancer Institute.

In the 1980s, preliminary studies suggested that beta-carotene might have chemopreventive abilities, so two large, randomized trials were begun to test the supplement's effect on lung cancer among cigarette smokers: the Alpha-Tocopherol Beta-Carotene (ATBC) Trial, which was conducted in Finland, and the Beta-Carotene and Retinol Efficacy Trial (CARET), which was conducted in the United States. Both trials were stopped after evidence accumulated that the supplements were associated with an increased risk of lung cancer. In CARET, the group that received beta-carotene supplements had a 28% greater incidence of lung cancer and 17% more deaths from all causes compared with the placebo group.

To determine if the effects of beta-carotene supplementation continued after participants stopped taking the supplements, Gary E. Goodman, M.D., of the Fred Hutchinson Cancer Research Center in Seattle, and colleagues followed the more than 18,000 participants in CARET for 6 years after the trial was stopped, until the end of 2001.

The increased risk of cardiovascular disease mortality quickly disappeared after participants stopped taking the supplements. However, women had a higher risk of death from cardiovascular disease or from any cause than men. In addition, the incidence of lung cancer and deaths from all causes decreased but did not disappear completely after the supplementation ceased. The excess risk of lung cancer was restricted primarily to females and former smokers.

"When chemoprevent

Contact: Sarah Zielinski or Kate Travis
Journal of the National Cancer Institute

Page: 1 2

Related medicine news :

1. First proof that cutting Rx drugs due to cost harms health
2. What are the benefits and harms of HRT?
3. Antioxidant supplementation may reduce incidence of cancer in men
4. Spina bifida: 70% of cases preventable by folic-acid supplementation
5. Resurgent rickets - Call for vitamin D supplementation for pregnant women and children
6. Prenatal zinc supplementation could impair childhood mental development
7. Meta-analysis of zinc supplementation shows positive growth effects for infants and children
8. Vitamin supplementation could slow arteriosclerosis in heart-transplant patients
9. Iron supplementation enhances aerobic training in iron-depleted women
10. Definition of persistent vegetative state available from American Academy of Neurology
11. Study finds happiness persists, despite illness

Post Your Comments:

(Date:8/9/2018)... ... August 09, 2018 , ... Striving ... Smart-pill bottle and mobile applications, DoseSmart announced today the availability of its ... medication management and medication adherence platform helps hospitals and health systems easily ...
(Date:8/7/2018)... ... 2018 , ... Sussex Vision Center, a multi-site optometry practice with deep community ... the practice in Coldwater, and over the last three decades has added locations in ... eye health services for patients of all ages. , “I wanted to find ...
(Date:8/3/2018)... ... 03, 2018 , ... On August 2, 2018 the JPML ordered that the ... Sadaka Associates, LLC has been litigating Zostavax injuries since 2011. ... Multidistrict Litigation for the thousands of people injured by Zostavax, a vaccine given to ...
(Date:8/2/2018)... ... August 02, 2018 , ... ... image e-sharing platform to connect clinicians inside and outside the network to vital ... stroke or trauma. , AHN joins other leading hospital systems nationwide in using ...
(Date:8/2/2018)... ... August 02, 2018 , ... A ... of topics in acute pain management. In The Role of Acute Care in ... Prescribing Engagement Network—an innovative approach to the opioid epidemic launched in the state ...
Breaking Medicine News(10 mins):
(Date:8/2/2018)... , ... August 02, 2018 , ... Although there is ... of it is contradictory and based on a generalized “best practices” approach. But now ... find the right combination for optimal health. , Technology exists to help people find ...
(Date:8/2/2018)... , ... August 01, 2018 , ... ... to announce the launch of its healthcare ecosystem that will be fuelled by ... make its platform available to the public and commence its token sale September ...
(Date:8/2/2018)... ... August 02, 2018 , ... Fitness Machine Technicians, specialists ... residences, announced today it is expanding into the North Charlotte area. The business will ... of the fastest growing markets in the country and fitness is a big business ...
Breaking Medicine Technology:
Cached News: