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St. Jude scientist to lead NCI Pediatric Preclinical Testing Program

pes. For both new agents and standard agents tested, pharmacokinetic studies will be performed in animal models to determine the serum drug levels and systemic drug exposures associated with antitumor activity. For selected molecularly targeted agents, the PPTP will evaluate whether target inhibition/modulation is achieved by the agent under the test conditions and whether this modulation is associated with antitumor activity. Results from the preclinical testing program will be correlated with the clinical activity and the pharmacokinetic profile of the tested agents in children to assess the predictive capabilities of the PPTP's childhood cancer panels and the animal models.


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Contact: Bonnie Cameron
bonnie.cameron@stjude.org
901-495-4815
St. Jude Children's Research Hospital
9-Nov-2004


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