HOME >> MEDICINE >> NEWS
St. Paul researcher receives national award

Insights into opioid receptors help tailor new drugs

Chemist Philip Portoghese of St. Paul, Minn., will be honored on March 28 by the world's largest scientific society for revealing precisely how drugs such as morphine interact with opioid receptors -- information that can be used to tailor-make new drugs, for example. He will receive the Alfred Burger Award in Medicinal Chemistry from the American Chemical Society at its 219th national meeting in San Francisco.

Like other biologically active compounds, opioids -- drugs derived from opium, such as morphine and heroin -- work by binding to receptors, specific protein pockets on the surfaces of cells.

"As researchers gain more insight into how molecules and receptors actually recognize each other, they can tailor-make drug molecules that are more effective or more selective," explained Portoghese, a medicinal chemist at the University of Minnesota. "And we can gain insight into how molecules bind by modifying them and their receptors in a systematic way."

For example, his team has developed genetic tools used to replace a bulky receptor building block with a smaller one, or a negatively charged receptor with a neutral one. The team analyzes whether and how much a molecule will bind to the modified receptor. "By feeding that information back into computer, we can refine our receptor models," Portoghese said.

In addition to basic research, he studies molecules as potential new drugs that could be used to treat opioid and cocaine addictions, or as painkillers with a lower risk of dependency. And Portoghese has been editor of the Journal of Medicinal Chemistry for 28 years.

Alfred Burger, the professor emeritus in chemistry at the University of Virginia for whom the award is named, characterizes Portoghese as "a chemist of so many interests that one can only guess whether he ever has time to rest."

Portoghese said his father was a pharmacist, "so I was able to make my own c
'"/>

Contact: Christina Curtin
c_curtin@acs.org
202-872-4400
American Chemical Society
21-Mar-2000


Page: 1 2

Related medicine news :

1. U of M researcher says Viagra may cause permanent vision loss in some men
2. Indiana University researchers closer to helping hearing-impaired using stem cells
3. Protein that helps skin cancer spread identified by Stanford researchers
4. US life expectancy about to decline, researchers say
5. Gene for age-related macular degeneration discovered by Yale researchers
6. Dartmouth researchers find where musical memories are stored in the brain
7. Columbia researchers receive $3 million to combat genetic killer of infants & toddlers
8. US cancer researchers launch first American-Israeli cancer conference
9. Mayo Clinic researcher calls for improved newborn screening
10. Hard choices: Pitt researcher presents findings on when to accept organ transplants
11. Brain-scanning technologies need standards, according to Stanford researcher

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:11/13/2018)... ... November 13, 2018 , ... Trumpet Behavioral Health Opens ... Spectrum Disorder. , Trumpet Behavioral Health (“Trumpet”) is pleased to announce the opening ... , Austin, TX; Cincinnati, OH; Columbus, OH; Dallas, TX; Fort Worth, TX; Long ...
(Date:11/13/2018)... ... November 13, 2018 , ... 2018 was a big year for ... a lot for marketers to prepare for in the new year. , Perhaps ... of AI. Most notably, AI is having a major effect on how users interact ...
(Date:11/13/2018)... ... November 13, 2018 , ... Nearly 8 in 10 (78%) adults in the ... of women’s health care, according to a new telephone survey of more than 1,000 ... that more open discussion regarding the full range of methods and health benefits would ...
(Date:11/13/2018)... ... ... Health iPASS today announced it has topped off its $7.2 million Series ... technology-focused venture capital fund led by Nigel Morris, co-founder of CapitalOne. The investment from ... non-recourse guarantee of patient payments to medical providers who are suffering from the rise ...
(Date:11/13/2018)... ... , ... World Vasectomy Day is an annual celebration of responsible men, promoting ... in the event each year. The best way to demonstrate the ease of the ... man questions about his experience in real time. This year, WVD will be streaming ...
Breaking Medicine News(10 mins):
(Date:11/13/2018)... ... November 13, 2018 , ... Digestive Health ... , Who can resist the temptations of sweet, rich, creamy taste delights like ... Almost no one! Unfortunately, these continuous yummy food enticements can leave us with ...
(Date:11/13/2018)... ... ... Prevent Blindness , the nation’s oldest volunteer eye health and safety organization, is ... in Vision and Public Health . The Award recognizes an individual, team, or organization ... and eye health at a community, state, national, and/or international level. , The ...
(Date:11/13/2018)... ... 13, 2018 , ... Through its Microbiome Grant Initiative ... study design, planning, sample collection, and analysis to a team of cancer researchers ... of Clinical Medicine, to compare the gut microbiome in individuals with MM, individuals ...
Breaking Medicine Technology:
Cached News: