HOME >> MEDICINE >> NEWS
Starzl Institute researchers to develop cell-based strategy for tranplant tolerance

PITTSBURGH, Oct. 16 Researchers from the University of Pittsburgh's Thomas E. Starzl Transplantation Institute have been awarded $2.3 million from the National Institute of Allergy and Infectious Diseases to explore whether a special type of immune system cell can help induce immune tolerance in kidney transplantation.

Specifically, the researchers will try to harness a subset of dendritic cells that have unique tolerance-enhancing qualities to see whether the cells can be directed to influence the acceptance of transplanted donor kidneys, including kidneys that are immunologically mismatched to the recipient. The studies, which will focus on nonhuman primates, are based on other animal research and evidence in transplant patients successfully weaned off all immunosuppression that show a subpopulation of dendritic cells might play a key role in convincing the immune system to accept a transplanted organ.

"We are hopeful that a clinical strategy to induce tolerance in transplant patients will emerge from these studies in nonhuman primates. Indeed, it is everyone's goal working in the field of transplantation to identify ways to promote the permanent, drug-free acceptance of transplanted organs," said the study's principal investigator, Angus W. Thomson, Ph.D., D.Sc., professor of surgery and immunology at the Thomas E. Starzl Transplantation Institute and the University of Pittsburgh School of Medicine.

The grant builds on several findings that have been reported in recent years by Dr. Thomson and members of his research team. In one set of studies, a pre-transplant infusion of these dendritic cell subtypes, which derive from lymphoid tissue or blood, allowed for prolonged survival in a mouse heart transplant model, even without the use of drugs to control rejection. In contrast, the better-known myeloid dendritic cells accelerated the rejection response.

According to the researchers, transplant patients who are off immunosuppres
'"/>

Contact: Lisa Rossi
412-647-3555
University of Pittsburgh Medical Center
15-Oct-2002


Page: 1 2

Related medicine news :

1. Transplant Pioneer Thomas E. Starzl Most Cited Researcher In Clinical Medicine Over Past 17 Years
2. Gladstone Institutes rank high in the scientist survey of best places for postdocs
3. Institute of Medicine advisory: Jan. 12 Briefing on Complementary and Alternative Medicine
4. Research by scientists affiliated with the Earth Institute at Columbia University
5. New Jersey Institute of Technology pioneers new way to teach engineers
6. Hopkins Institute for Global Tobacco Control receives elite recognition from PAHO/WHO
7. Weizmann Institute receives $8 million grant from Flight Attendant Medical Research Institute
8. Six new Roybal Centers for Applied Gerontology established by National Institute on Aging
9. American College of Chest Physicians announces new Critical Care Institute
10. UGA professor receives $3 million grant from National Cancer Institute for breast cancer research
11. National Institute on Aging Neuroimaging Initiative for Alzheimers disease

Post Your Comments:
(Date:7/22/2014)... Bayonne, NJ (PRWEB) July 22, 2014 CarePoint ... been recently elected as the President of the medical staff ... Dr. Levine will serve as President, as voted on by ... interests of the medical staff in relation to the administration ... the needs of physicians and to work to make the ...
(Date:7/22/2014)... 5i Sciences, a medical technology company ... Molly Coye, M.D., M.P.H. to a role as Senior ... on the market introduction of innovative technologies that impact ... advise on strategies for building a successful commercial healthcare ... Dr. Coye is currently the Chief Innovation Officer of ...
(Date:7/22/2014)... (PRWEB) July 22, 2014 According to ... Health care, Automobile, Aerospace & Defense, Marine and Mining) ... Middle East, and Rest of the world) - Forecast ... is expected to grow at a CAGR 8.00% to ... Europe is estimated to grow at a CAGR of ...
(Date:7/22/2014)... The Latin America Drilling fluid and Completion fluid ... fluid market in Latin America with analysis and forecast of ... America is estimated to grow from around $0.93 billion in ... 9.2%, for the given period. , Browse through the TOC ... Report, to get an idea of the in-depth analysis provided. ...
(Date:7/22/2014)... The donation from the Edusei Foundation was greatly appreciated by ... of strategic engineering, such assistance tends to etch good memories ... It provided a sense of family to them, which the ... Foundation donated various amounts of; milk, soap, frytol, sugar, ... Government of Ghana established the Kumasi Children’s Home in 1965 ...
Breaking Medicine News(10 mins):Health News:Dr. Howard Levine Elected President of the Medical Staff at Bayonne Medical Center 2Health News:5i Sciences Announces Appointment of a Senior Healthcare Consultant and Successful Financing 2Health News:Global Actuators Market Estimated to Reach $59.32 Billion by 2019 – New Report by MarketsandMarkets 2Health News:Global Actuators Market Estimated to Reach $59.32 Billion by 2019 – New Report by MarketsandMarkets 3Health News:Global Actuators Market Estimated to Reach $59.32 Billion by 2019 – New Report by MarketsandMarkets 4Health News:Latin America Drilling Fluid & Completion Fluid Market is Expected to Reach $1.45 Billion in 2018 - New Report by MicroMarket Monitor 2Health News:Latin America Drilling Fluid & Completion Fluid Market is Expected to Reach $1.45 Billion in 2018 - New Report by MicroMarket Monitor 3Health News:Latin America Drilling Fluid & Completion Fluid Market is Expected to Reach $1.45 Billion in 2018 - New Report by MicroMarket Monitor 4Health News:Latin America Drilling Fluid & Completion Fluid Market is Expected to Reach $1.45 Billion in 2018 - New Report by MicroMarket Monitor 5Health News:Latin America Drilling Fluid & Completion Fluid Market is Expected to Reach $1.45 Billion in 2018 - New Report by MicroMarket Monitor 6Health News:Edusei Foundation Donates Food and Needed Items to Kumasi Children’s Home in Ashanti Region of Ghana 2
(Date:7/22/2014)...  July 22, 2014 The ... Reuters , the world,s leading provider of ... announced Cortellis Clinical Trials Intelligence , ... industry-first milestone with the documentation of more ... professionals with greater and quicker access to ...
(Date:7/22/2014)... WuXi PharmaTech (Cayman) Inc. (NYSE: WX ... company with operations in China and ... it will release financial results for the second quarter of ... August 13, 2014 (which will be Thursday morning, August 14, ... the investor relations section of the Company,s website at ...
(Date:7/22/2014)...  Vernalis plc (LSE: VER) and Tris Pharma, Inc. ... CCP-08, the third programme to achieve this milestone ... this collaboration, POC requires the successful completion of ... study against an immediate release reference product. As ... a milestone payment to Tris. ...
Breaking Medicine Technology:Thomson Reuters Cortellis Clinical Trials Intelligence Reaches Industry Milestone with 180,000 Clinical Trials 2Thomson Reuters Cortellis Clinical Trials Intelligence Reaches Industry Milestone with 180,000 Clinical Trials 3WuXi PharmaTech Schedules Second-Quarter 2014 Earnings Release 2Third Product in Vernalis' Cough Cold Pipeline (CCP-08) Achieves Proof-of-Concept 2Third Product in Vernalis' Cough Cold Pipeline (CCP-08) Achieves Proof-of-Concept 3
Cached News: