HOME >> MEDICINE >> NEWS
Statins effective in long term, Nordic study suggests

Statins--a class of drugs that lower cholesterol and are associated with cardiovascular benefits-- are effective in the long term, conclude authors of a study in this week's issue of THE LANCET.

Few data are available about the long-term effects of statins because previous trials have not extended beyond 5-6 years; however, the results of a Nordic study with a follow-up of 10 years has found that, in the long term, statins may decrease mortality rate and incidence of cancer. The Scandinavian Simvastatin Survival Study (4S) led by Timo Strandberg (University of Helsinki, Finland) and colleagues was launched in 1989. Patients from five participating countries-Denmark, Finland, Iceland, Norway and Sweden-were randomly assigned to 5 years of statin therapy with simvastatin or allocated a placebo. The results of the trial were published in THE LANCET 10 years ago (Lancet 1994; 344: 1383-89). 5-year follow-up showed that statins lowerd lipid fractions and cholesterol concentrations; furthermore, simvastatin treatment reduced cardiovascular mortality and coronary mortality by 36% and 43%, respectively. This trial was the first to demonstrate the advantage of lowering cholesterol in patients with coronary heart disease, and ushered in a revolution in treating heart disease more aggressively.

The long-term follow-up results compare the initial 2221 patients who have had simvastatin for 10 years, compared with the 2223 patients who initially received placebo (and only started statins 5 years ago after the 4S trial was completed and the results of statin benefit became known). Overall, there was a 17% reduction in cardiovascular mortality and a 24% decrease in coronary mortality for 10-year statin use compared with 5-year use for people given placebo in the original trial who later used statins. There was a suggestion that 10-year statin use was associated with a decreased incidence of cancer, although the 12% reduction for long-term statin users was not stat
'"/>

Contact: Joe Santangelo
j.santangelo@elsevier.com
1-212-633-3810
Lancet
26-Aug-2004


Page: 1 2

Related medicine news :

1. Statins show early promise for treating multiple sclerosis
2. Statins and aspirin may protect against severe vision loss in elderly
3. Statins could reduce stroke risk by a third
4. Statins may inhibit calcium growth on aortic valve in the elderly
5. International Study Finds Statins Raise Good Cholesterol, Wake Forest Physician Reports
6. Strategy effective against drug resistant tuberculosis
7. Study shows patch therapy may be as effective as oral medications
8. Chronic pain treatments more effective when taken together, new study shows
9. Geodon effective in psychiatric emergencies; Sharply reduces time in restraints
10. Costs of antidepressants could have funded effective alternatives
11. New ways to design safer & more effective topical (transdermal) drug delivery announced in the PNAS

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Statins effective long term Nordic study suggests

(Date:7/26/2014)... New York (PRWEB) July 26, 2014 ... filed in state and federal litigations since the 2012 ... has surpassed 3,700 filings, Bernstein Liebhard LLP reports. According ... at least 2,064 cases have been filed in the ... Rejuvenate Hip Stem and the ABG II Modular Hip ...
(Date:7/26/2014)... 26, 2014 “Today, we introduce our ... clients all over the world. All these models are ... designed for the UK market,” says the CEO of ... suppliers of women’s special occasion outfits. , Ladies have ... comes. DressesOnlineShops.co.uk is one of the best choices for ...
(Date:7/26/2014)... “BRIC Sinuscopes Market Outlook to 2020,? provides ... report provides value, in millions of US dollars, volume ... market segments – Rigid Non-Video Sinuscopes. , The report ... each of these market categories, and global corporate-level profiles ... and deals related to the Sinuscopes market wherever available. ...
(Date:7/26/2014)... According to the Tinnitus ... this is a comprehensive guide that consists ... all types of disorders related to ... due to Ménière's disease ,     Objective ... tinnitus ,     Inner, middle or external ...
(Date:7/26/2014)... New York, New York (PRWEB) July 26, 2014 ... continue to be filed in U.S. courts, Bernstein ... calling on federal health regulators to ban uterine morcellation. ... individuals include a 46-year-old mother of four from California ... of uterine cancer called leiomyosarcoma just 10 days after ...
Breaking Medicine News(10 mins):Health News:Stryker Hip Lawsuit Filings in State and Federal Litigations Continue to Rise, Bernstein Liebhard LLP Reports 2Health News:Stryker Hip Lawsuit Filings in State and Federal Litigations Continue to Rise, Bernstein Liebhard LLP Reports 3Health News:Famous Supplier DressesOnlineShops.co.uk Announces Its New Selection of Prom Dresses for the UK Market 2Health News:Sinuscopes Market in BRIC (Brazil, Russia, India & China) Forecast to 2020 Report Available at MarketOptimizer.org 2Health News:Sinuscopes Market in BRIC (Brazil, Russia, India & China) Forecast to 2020 Report Available at MarketOptimizer.org 3Health News:Sinuscopes Market in BRIC (Brazil, Russia, India & China) Forecast to 2020 Report Available at MarketOptimizer.org 4Health News:Tinnitus Miracle Book Review Exposes Thomas Coleman's Guide for Treating Tinnitus – Vkool.com 2Health News:Morcellator Lawsuit News: Bernstein Liebhard LLP Notes New Calls for Ban on Uterine Mocellation In Light of Cancer Risk 2Health News:Morcellator Lawsuit News: Bernstein Liebhard LLP Notes New Calls for Ban on Uterine Mocellation In Light of Cancer Risk 3Health News:Morcellator Lawsuit News: Bernstein Liebhard LLP Notes New Calls for Ban on Uterine Mocellation In Light of Cancer Risk 4
(Date:7/25/2014)... Research and Markets has announced ... Market 2014-2018" report to their offering. ... Diagnostic Device An ophthalmic diagnostic device ... or deficiency in the human visual pathway. Ophthalmic devices ... presbyopia, cataracts, glaucoma, retinal disorders, conjunctivitis, and dry eyes. ...
(Date:7/25/2014)... July 25, 2014 Leading events organizer ... returning for the seventh year to São Paulo, ... August 2014. The event will co-locate with Food Ingredients ... most comprehensive meeting point for the pharmaceutical industry. ... countries for pharmaceutical sales are now exploring the ...
(Date:7/24/2014)... Calif. , July 24, 2014   AcelRx ... pharmaceutical company focused on the development and commercialization of ... pain, today confirmed the PDUFA date for Zalviso remains ... that a rumor circulated online stating the Food and ... 24, 2014 there has been no notification to the ...
Breaking Medicine Technology:Global Ophthalmic Diagnostic Devices Market 2014-2018: Key Vendors are Alcon, Carl Zeiss, Haag-Streit and Topcon 2CPhI South America 2014 Launches with Generics Showing Huge Growth 2CPhI South America 2014 Launches with Generics Showing Huge Growth 3CPhI South America 2014 Launches with Generics Showing Huge Growth 4AcelRx Pharmaceuticals Confirms July 27, 2014 PDUFA Date for Zalviso 2
Cached News: