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Statins effective in long term, Nordic study suggests

istically significant.

Dr Strandberg comments: "The main finding of this 10-year follow-up study of the participants of 4S was that the survival benefit of patients allocated simvastatin compared with those allocated placebo that accrued during the double-blind trial period persisted during follow-up. The reduction in the relative risk between the two original treatment groups was not unexpected, because open-label treatment with lipid-lowering drugs (mostly statins) was given to most patients when the trial ended. After 3 years, more than 80% of patients in both groups were using these drugs. Nevertheless, the absolute differences in all-cause, cardiovascular, and coronary mortality achieved during the double-blind trial changed little during the 5-year extension of the follow-up".


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Contact: Joe Santangelo
j.santangelo@elsevier.com
1-212-633-3810
Lancet
26-Aug-2004


Page: 1 2

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