HOME >> MEDICINE >> NEWS
Stem cell factor: Secret to liver's fountain of youth

Following surgical liver resection, a technique known as partial hepatectomy, which is often employed in the removal of benign or malignant tumors, a large reservoir of stem cell factor (SCF) in the liver drives increased hepatocyte proliferation in order to restore liver mass to normal. Lisa Colletti and colleagues from the University of Michigan report their findings in the November 3 issue of the Journal of Clinical Investigation.

Following most cases of partial hepatectomy the remnant liver regenerates until normal hepatic mass is reestablished. However the specific factors involved in this complex regulatory phenomenon remain to be completely defined.

Colletti and colleagues demonstrate that hepatic SCF levels change dramatically following partial hepatectomy in mice, and that SCF blockade, either by administration of anti-SCF antibodies or by using genetically altered, SCF-deficient mice, inhibits hepatocyte proliferation. Furthermore, SCF administration in SCF-deficient mice was shown to restore hepatocyte proliferation to normal and this effect occurs via an IL-6mediated pathway.

Colletti and colleagues suggest that while hepatic homeostasis and regeneration likely involves multiple complex mechanisms and pathways, their current report indicates that SCF plays a significant role in maintaining and reestablishing the health of the liver.


'"/>

Contact: Brooke Grindlinger
science_editor@the-jci.org
212-342-9006
Journal of Clinical Investigation
3-Nov-2003


Page: 1

Related medicine news :

1. HHS Secretary names UO researcher to national health advisory panel
2. South African MRC hosts the African branch office of EDCTP Secretariat
3. Physician organizations urge Secretary Thompson to defend NIH review process
4. Secret documents reveal how tobacco industry targeted gay men
5. Energy Secretary Bill Richardson to make major cancer treatment annoucement in Pittsburgh area
6. Secret agents secret revealed - shaken martinis have superior antioxidant properties to those that are stirred
7. Unlocking Secrets Of The Bodys Inner Clock; Researchers Discover Key Control Mechanism For An Area Of The Brain That Regulates Sleep
8. English-speaking Hispanic youth more likely to have sex early
9. Certain gun storage practices can reduce risk of youth firearm injuries, suicide
10. State policies decrease youth smoking, drinking and sex
11. Study links racial and ethnic gap in youth violence to social factors

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Stem cell factor Secret liver fountain youth

(Date:10/30/2014)... Amy Norton HealthDay Reporter ... common plastics, chemical during pregnancy may have effects on genital ... found that baby boys born to moms with greater exposure ... anogenital distance -- the space between the genitals and anus. ... a marker of exposure to androgens ("male" hormones) during pregnancy. ...
(Date:10/30/2014)... (HealthDay News) -- Eating a low-carb, high-fat diet could ... to new research. A review of five ... that focuses on foods like bacon, eggs, heavy cream, ... in adults whose condition doesn,t improve with medication. ... people with epilepsy whose seizures are not stopped by ...
(Date:10/30/2014)... care respects the fact that a patient,s body ... treatment. Over a third of cancer patients experience ... their conditions. And, increasingly, care providers are exploring ... navigate mental health challenges. A University of Colorado ... Psycho-Oncology asks an important question: after ...
(Date:10/29/2014)... – Many of the women at first acted surprised. Some ... researchers why they had not used the study products assigned ... trial that, as a likely consequence, did not find any ... , The women were among 127 former VOICE participants ... agreed to take part in in-depth interviews and/or focus group ...
(Date:10/28/2014)... the inner and outer body and organ surfaces in ... pancreas and in the inner ear," said Moritz Gegg. ... BBs and are precisely positioned on many of these ... movements be coordinated so precisely that for example mucus ... be perceived from sensory inner ear hair cells," added ...
Breaking Medicine News(10 mins):Health News:Plastics' Chemical May Affect Baby Boys' Genital Development 2Health News:Plastics' Chemical May Affect Baby Boys' Genital Development 3Health News:High-Fat, Low-Carb Diet May Help With Tough-to-Treat Epilepsy 2Health News:High-Fat, Low-Carb Diet May Help With Tough-to-Treat Epilepsy 3Health News:Decades of research: Effectiveness of phone counseling for cancer patients still unknown 2Health News:Women who took part in VOICE speak up about why they didn't use HIV prevention products 2Health News:Women who took part in VOICE speak up about why they didn't use HIV prevention products 3Health News:New insights into the development of ciliopathies 2
(Date:10/30/2014)... 2014 Boston Scientific Corporation (NYSE: ... Credit Suisse Annual Healthcare Conference on Tuesday, November 11, ... Dan Brennan , executive vice president and chief financial ... at approximately 8:00 a.m. PT followed by a question ... the presentation and question and answer session will be ...
(Date:10/30/2014)... ANGELES , Oct. 30, 2014   ... company devoted to bringing new products to market, ... drug called TetraStem. TetraStem is a topical liquid ... delivery system that can convert oral medication active ... registered as a first aid antibiotic to help ...
(Date:10/30/2014)... CVS Health (NYSE: CVS ) announced ... leading regional health systems to enhance access to high-quality, affordable ... Baptist Health System in Alabama ; Community ... Pennsylvania , Northwest Medical Center, including Oro ... Healthcare in Tennessee ; and Premier Health ...
Breaking Medicine Technology:Boston Scientific To Participate In 2014 Credit Suisse Annual Healthcare Conference 2ViaDerma, Inc. Lead Product TetraStem Shown Effective in Fighting Staph Infections including MRSA 2ViaDerma, Inc. Lead Product TetraStem Shown Effective in Fighting Staph Infections including MRSA 3CVS Health Announces New Clinical Affiliations with Leading Regional Health Systems 2CVS Health Announces New Clinical Affiliations with Leading Regional Health Systems 3CVS Health Announces New Clinical Affiliations with Leading Regional Health Systems 4
Cached News: