HOME >> MEDICINE >> NEWS
Stem cell factor: Secret to liver's fountain of youth

Following surgical liver resection, a technique known as partial hepatectomy, which is often employed in the removal of benign or malignant tumors, a large reservoir of stem cell factor (SCF) in the liver drives increased hepatocyte proliferation in order to restore liver mass to normal. Lisa Colletti and colleagues from the University of Michigan report their findings in the November 3 issue of the Journal of Clinical Investigation.

Following most cases of partial hepatectomy the remnant liver regenerates until normal hepatic mass is reestablished. However the specific factors involved in this complex regulatory phenomenon remain to be completely defined.

Colletti and colleagues demonstrate that hepatic SCF levels change dramatically following partial hepatectomy in mice, and that SCF blockade, either by administration of anti-SCF antibodies or by using genetically altered, SCF-deficient mice, inhibits hepatocyte proliferation. Furthermore, SCF administration in SCF-deficient mice was shown to restore hepatocyte proliferation to normal and this effect occurs via an IL-6mediated pathway.

Colletti and colleagues suggest that while hepatic homeostasis and regeneration likely involves multiple complex mechanisms and pathways, their current report indicates that SCF plays a significant role in maintaining and reestablishing the health of the liver.


'"/>

Contact: Brooke Grindlinger
science_editor@the-jci.org
212-342-9006
Journal of Clinical Investigation
3-Nov-2003


Page: 1

Related medicine news :

1. HHS Secretary names UO researcher to national health advisory panel
2. South African MRC hosts the African branch office of EDCTP Secretariat
3. Physician organizations urge Secretary Thompson to defend NIH review process
4. Secret documents reveal how tobacco industry targeted gay men
5. Energy Secretary Bill Richardson to make major cancer treatment annoucement in Pittsburgh area
6. Secret agents secret revealed - shaken martinis have superior antioxidant properties to those that are stirred
7. Unlocking Secrets Of The Bodys Inner Clock; Researchers Discover Key Control Mechanism For An Area Of The Brain That Regulates Sleep
8. English-speaking Hispanic youth more likely to have sex early
9. Certain gun storage practices can reduce risk of youth firearm injuries, suicide
10. State policies decrease youth smoking, drinking and sex
11. Study links racial and ethnic gap in youth violence to social factors

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/12/2017)... ... October 12, 2017 , ... The American College of ... Carol Friedman, PhD, FACMI, during the Opening Session of AMIA’s Annual Symposium in Washington, ... In honor of Morris F. Collen, a pioneer in the field of medical informatics, ...
(Date:10/12/2017)... (PRWEB) , ... October 12, 2017 , ... ... Mohebi Hair Restoration, has recently contributed a medical article to the newly revamped ... cosmetictown.com. Dr. Mohebi’s article spotlights the hair transplant procedure known as Follicular ...
(Date:10/12/2017)... ... October 12, 2017 , ... On Saturday, October 21, the Health & ... by Moonlight to raise money for the American Heart Association Heart Walk. Teams of ... will work together to keep their treadmills moving for 5 hours. Treadmills will start ...
(Date:10/12/2017)... (PRWEB) , ... October 12, 2017 , ... ... of $3,296 in property taxes a year. In some states—like New York, New ... , By contrast, many overseas retirement havens have extremely low property-tax rates, which ...
(Date:10/12/2017)... ... October 12, 2017 , ... ... its enhanced Pepper Flow promotional review platform at the Promotional Review Committee ... insight-driven capabilities help marketers streamline the medical, legal, and regulatory review (MLR) ...
Breaking Medicine News(10 mins):
(Date:10/2/2017)... 2, 2017 Diplomat Pharmacy, Inc. (NYSE: ... and Consulting, LLC , and named its founder as ... in Tennessee , will operate under ... EnvoyHealth,s service offerings for health care partners to include ... "In an interoperable world, technology delivers ...
(Date:10/2/2017)... PHILADELPHIA , Oct. 2, 2017 Halo Labs announces ... particle analysis system called the HORIZON at MIBio 2017 in ... analyzes subvisible and visible particulate matter in biopharmaceutical samples with unprecedented ... use of the novel technique Backgrounded Membrane Imaging. ... The HORIZON subvisible particle analysis system ...
(Date:9/28/2017)... 28, 2017 Cohen Veterans Bioscience and Early ... of wearable and home sensors for real-time monitoring of ... Foundation, a nonprofit organization focused on disruptive health solutions ... affordable analytical system to record and integrate behavioral, cognitive, ... ...
Breaking Medicine Technology:
Cached News: