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the researchers found that patients receiving the higher dose of prednisone remained free of disease progression for 14 months versus five months for patients receiving the lower dosage. Most importantly, the investigators found that patients receiving the higher doses of prednisone lived significantly longer (37 months versus 26 with the lower dose).

We found that the long term use of prednisone delayed progression of the disease and kept patients alive longer. Furthermore, 50 mg of prednisone every other day was well tolerated, which means that patients remain active and have a much better quality of life for longer, said Dr. Berenson.

Future studies will examine whether prednisone is effective to prolong remission for patients with other cancers such as leukemia or lymphoma. In addition, other drug combinations that include prednisone will be evaluated as maintenance therapy for patients with multiple myeloma.

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Contact: Kelli Stauning
kelli.stauning@cshs.org
310-423-3674
Cedars-Sinai Medical Center
2-May-2002

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