DENVER, CO While Lyme disease is usually cured with antibiotic treatment, some patients experience persistent fatigue and cognitive dysfunction. In a study presented at the annual meeting of the American Academy of Neurology, researchers share their experience in a study evaluating ceftriaxone, a broad spectrum antibiotic they hoped would be effective in treating post-Lyme disease symptoms.
In a double blind, single center, randomized clinical trial, 55 Lyme disease patients with persistent severe fatigue were randomly assigned to receive the ceftriaxone or a placebo. Although patients assigned to ceftriaxone showed significant improvement in fatigue compared to the placebo group, seven percent were hospitalized with adverse treatment effects, according to study author Lauren Krupp, MD, of State University of New York -- Stony Brook.
We had hoped to find a treatment option for these patients that would improve their symptoms and reduce the level of infection, comments Krupp. But given these adverse effects, and because neither cognitive functioning nor laboratory measure of infection were improved, our study does not support the use of repeated courses of ceftriaxone.
Krupp added, The observation that fatigue did improve is very encouraging and hopefully other treatment approaches that are better tolerated or safer for patients can be identified to ameliorate post-Lyme disease symptoms.
Page: 1 Related medicine news :1
Contact: Cheryl Alementi
American Academy of Neurology
. Still time to apply for the $10,000 Maxwell A. Pollack Award!2
. Still mulling over last nights argument? It could affect your heart3
. Strategy effective against drug resistant tuberculosis4
. Study shows patch therapy may be as effective as oral medications5
. Chronic pain treatments more effective when taken together, new study shows6
. Geodon effective in psychiatric emergencies; Sharply reduces time in restraints7
. Costs of antidepressants could have funded effective alternatives8
. New ways to design safer & more effective topical (transdermal) drug delivery announced in the PNAS9
. Government wasting your taxpayer money on ineffective drug cure10
. Neurobehavioral function during coma, stroke rehabilitation effective for elderly11
. European folic acid policies are not effective enough