Stress Hormone Tied To Depression And Conduct Disorder In Pregnant Teens

University Park, Pa. --- Shedding new light on the biology of violence, a Penn State-led team has found evidence, for the first time, in pregnant teens that lower concentrations of a stress hormone in the blood are linked to greater numbers of depression and conduct disorder symptoms.

Dr. Elizabeth Susman, the Jean Phillips Shibley Professor of Biobehavioral Health and leader of the study, says, "We've identified a biological marker for anti-social behavior and depression in pregnant teens. While we don't know if the lower hormone concentrations make the teen vulnerable to conduct disorder or if, instead, antisocial behavior and depression alter the concentration of the hormone, we do now have evidence that the hormone is associated with emotions and behavior during pregnancy."

The research is detailed in the current issue (April) of the Journal of the American Academy of Adolescent Psychiatry in a paper, "Corticotropin-Releasing Hormone and Cortisol: Longitudinal Associations with Depression and Antisocial Behavior in Pregnant Adolescents."

Susman's co-authors are Karen H. Schmeelk, a Penn State doctoral candidate in biobehavioral health; Brenda K. Worrall, Association of Teachers of Preventive Medicine Fellow, Centers for Disease Control and Prevention, Atlanta; Dr. Douglas A. Granger, Penn State assistant professor of biobehavioral health; Dr. Angelo Ponirakis, postdoctoral fellow, University of Montreal; and Dr. George P. Chrousos, chief, section of Pediatric Endocrinology, National Institutes of Child Health and Human Development, Bethesda, Md.

The study sample consisted of 59 teens, 58 White and one African American, who were interviewed and assessed for depression and antisocial behavior early and late in their pregnancies as well as after the birth of their children. Blood samples were drawn at the first interview and the hormone, corticotropin releasing hormone (CRH), was measured.

The resear

Contact: Barbara Hale
Penn State

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