Stroke news tips for Friday, Feb. 6, 2004

n tissue death, possibly allowing doctors more time to administer important clot-busting therapy, according to a small study of ischemic stroke patients. In a randomized trial, eight patients received 100 percent oxygen by facemask for eight hours, while four patients got only room air. The volume of brain tissue affected by the stroke decreased to 78 percent at three hours in the oxygen group; then increased to 114 percent at 24 hours and 194 percent at one week. In the control group, the volume of affected brain tissue increased to 145 percent at three hours, 229 percent at 24 hours and 253 percent at one week. There was no evidence of adverse effects from the 8-hour oxygen therapy. Early "hyperoxia" therapy appears safe and may improve clinical and MRI parameters after ischemic stroke, the scientists reported. They suggest oxygen treatment could become a widely used strategy to extend the "time window" available for effective therapy after iscemic stroke.

4 p.m. Abstract P232 Clot-busting therapy plus angioplasty helps some stroke patients. Japanese doctors report promising results from experimentally combining clot-busting therapy with brain balloon angioplasty in patients with acute ischemic stroke leading to total blockage of the internal carotid artery. Sixteen patients received treatment with intra-arterial fibrinolysis plus balloon angioplasty. Reopening the blocked artery was achieved in six patients but not in the other 10. Another 38 patients received "conservative" treatment. Scores measuring neurological function were significantly improved in the six patients compared to the others. "Successful endovascular treatment for recanalization can probably improve clinical outcome even in patients showing serious symptoms due to acute embolic occlusion of the internal carotid artery," the researchers concluded.

4 p.m. Abstract P250 All types of ischemic strokes occur most often in morning. From the Norther

Contact: Carole Bullock
American Heart Association

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6. Stroke treatment window stays open longer than thought, say Stanford researchers
7. Stroke news tips for Saturday, Feb. 7, 2004
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