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Stroke news tips for Friday, Feb. 6, 2004

identified protein called growth arrest-specific 6 gene product (GAS6) has clot-producing effects. So a team of Spanish researchers looked at whether the prevalence of one variation of the GAS6 involving a single nucleotide polymorphism (SNP) differed among patients with ischemic or hemorrhagic stroke and healthy individuals. Genetic profiles were studied in 343 patients with ischemic strokes, 157 with hemorrhagic strokes, and 108 healthy controls. It turns out that one gene type with the SNP variant, the AA allele, was less prevalent than the GG allele among stroke patients than the healthy controls. Prevalence of ischemic stroke was 12.5 percent and hemorrhagic stroke 10.2 percent in the AA's, compared to 20.4 percent for controls. The GG allele was present in 40.2 percent of the ischemic stroke patients and 43.3 percent of the hemorrhagic stroke patients, compared to 43.5 percent for the controls. "This finding suggests that this genotype [GAS6-intron8 AA genotype] is associated to mechanisms protective against stroke that deserve further study."


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Contact: Carole Bullock
carole.bullock@heart.org
214-706-1279
American Heart Association
6-Feb-2004


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