HOME >> MEDICINE >> NEWS
Studies Look At Threshold Effect Of Cholesterol-Lowering "Statin" Drugs

DALLAS, April 21 -- Do individuals gain progressive benefits in heart attack protection as the drugs, called statins, take cholesterol levels to "new lows?" This is the topic of three reports and an editorial appearing in today's Circulation: Journal of the American Heart Association.

"An important question is how much additional benefit do individuals who have had a heart attack get from reducing their low-density lipoprotein, (LDL), or 'bad' cholesterol levels from low to very low levels, (below the recommended 100 milligrams/deciliter)? Is it considerable, small amounts or none?" asks Scott M. Grundy, M.D., Ph.D., who wrote an accompanying editorial in Circulation. He is director of the center for human nutrition at the University of Texas Southwestern Medical Center in Dallas.

In one report researchers found that the benefits of the popular statin drugs -- shown to sharply reduce heart attack risk in individuals with elevated blood levels of cholesterol -- taper off, indicating a "threshold" effect when LDL reaches 125 mg/dL, according to Frank M. Sacks, M.D., associate professor of medicine, and other researchers at Brigham and Women's Hospital and Harvard Medical School, Boston.

Another report in the same issue however suggested continued benefit down to a level of 100 mg/dL, although there was some lessening of benefit as LDL approached the lower levels.

Even though the data suggest that there may be attenuation in the benefit of cholesterol lowering below 125 mg/dL, Grundy stresses that these reports should not be taken as the final word on the issue. "For the present, the guidelines by the National Cholesterol Education Program (NCEP), endorsed by the American Heart Association, offer the most reliable basis for physicians' decisions regardless of the optimal lower limit for LDL cholesterol," says Grundy. A new statin trial, the Treating to New Target (TNT) study, should provide the answers concerning lower limit of benefit, but
'"/>

Contact: Carole Bullock
caroleb@amhrt.org
214-706-1279
American Heart Association
20-Apr-1998


Page: 1 2 3 4 5

Related medicine news :

1. Studies underscore genetic involvement in nicotine addiction & aggressive hostility
2. Studies address issues of risk and survival in rapidly increasing GI cancers
3. Studies examine coffee drinking and risk of liver and colorectal cancers
4. Studies reveal physicians attitudes on end-of-life care
5. Studies from the November issue of The Archives of Dermatology, a theme issue on facial rejuvenation
6. Studies link obesity to increased frequency of heartburn symptoms; greater risk of esophageal cancer
7. Studies demonstrate positive data in treatment of hepatitis C
8. Studies examine risk factors and potential consequences associated with prehypertension
9. Studies show ACTOS(R) (pioglitazone HCl) has positive effects on various components of dyslipidemia
10. Studies identify risk factors for colon cancer
11. Studies indicate healthy eating may affect cancer development, improve digestive system

Post Your Comments:
(Date:9/1/2015)... ... ... For many men, the first thing they notice when they go to button their white ... fitting shirt with a collar that doesn’t close against the skin, creating a sloppy look. ... all day because it’s uncomfortable. Now men in suits will be able to do ...
(Date:9/1/2015)... ... September 01, 2015 , ... Earth Brands, ( ... fall collection. Every customer who buys an Earth Brand shoe will be given ... with Trees for the Future, a nonprofit dedicated to planting more trees. Earth ...
(Date:9/1/2015)... ... September 01, 2015 , ... Celebrity hairstylist and Beauty ... “The Beauty Behind the Fashion” on Thursday, Oct. 1, at the La Valencia ... the spotlight on the collaboration between fashion and professional hair, makeup and nail design. ...
(Date:9/1/2015)... ... September 01, 2015 , ... ... to efficiently cure and prevent different malignancies. Some options for cancer treatment ... properties due to which distinctive approach is necessary for effective treatment. Several ...
(Date:9/1/2015)... ... 01, 2015 , ... Virginia entrepreneur Marcella Ellis, CEO and ... her firm’s success in the hair care and distribution industry through her combination ... will be providing “Look and learn” live demonstrations, as well as promoting her ...
Breaking Medicine News(10 mins):Health News:Getting Rid of Double Chins: New FDA Approved Kybella Treatment Proving Very Popular Among Professional Men at Crutchfield Dermatology 2Health News:Earth Brands Footwear Partners with Trees for the Future for Launch of Fall Collection: Buy Shoes, Plant a Tree 2Health News:Earth Brands Footwear Partners with Trees for the Future for Launch of Fall Collection: Buy Shoes, Plant a Tree 3Health News:Celebrity Hairstylist Ted Gibson Explores Fusion of Fashion and Beauty at “Beauty Behind the Fashion” at Fashion Week San Diego Proceeds to benefit THIRST Project 2Health News:Celebrity Hairstylist Ted Gibson Explores Fusion of Fashion and Beauty at “Beauty Behind the Fashion” at Fashion Week San Diego Proceeds to benefit THIRST Project 3Health News:CD Antigen Cancer Market and Pipeline Landscape Examined in Comprehensive Kuick Research Report Published at MarketPublishers.com 2Health News:CD Antigen Cancer Market and Pipeline Landscape Examined in Comprehensive Kuick Research Report Published at MarketPublishers.com 3Health News:Beauty Entrepreneur creates hair extension smart machine and mobile app inspired by UBER technology 2
(Date:9/1/2015)... OAKS, Calif. and BRUSSELS ... AMGN ) and UCB (Euronext Brussels: UCB) ... (STudy evaluating effect of RomosozUmab Compared with Teriparatide ... for fracture pReviously treated with bisphosphonatE therapy). The ... statistically significant difference in favor of romosozumab in ...
(Date:9/1/2015)... Emerus Holdings, a national and innovative ... diagnostic care in partnership with leading health systems, ... to receive a strategic investment from Welsh, Carson, ... care investment firm. Emerus partners with ... and ambulatory clinical services to communities across a ...
(Date:9/1/2015)... 1, 2015  Edwards Lifesciences Corporation (NYSE: EW ... valves and hemodynamic monitoring, is scheduled to present at ... Hyatt Regency Boston in Boston, Massachusetts ... Michael A. Mussallem , Edwards Lifesciences, chief executive officer, ... a company discussion with conference attendees at 10:10 a.m. ...
Breaking Medicine Technology:Amgen And UCB Announce Positive Top-Line Results From Open-Label Phase 3 Study Of Romosozumab Compared With Teriparatide 2Amgen And UCB Announce Positive Top-Line Results From Open-Label Phase 3 Study Of Romosozumab Compared With Teriparatide 3Amgen And UCB Announce Positive Top-Line Results From Open-Label Phase 3 Study Of Romosozumab Compared With Teriparatide 4Amgen And UCB Announce Positive Top-Line Results From Open-Label Phase 3 Study Of Romosozumab Compared With Teriparatide 5Amgen And UCB Announce Positive Top-Line Results From Open-Label Phase 3 Study Of Romosozumab Compared With Teriparatide 6Amgen And UCB Announce Positive Top-Line Results From Open-Label Phase 3 Study Of Romosozumab Compared With Teriparatide 7Amgen And UCB Announce Positive Top-Line Results From Open-Label Phase 3 Study Of Romosozumab Compared With Teriparatide 8Amgen And UCB Announce Positive Top-Line Results From Open-Label Phase 3 Study Of Romosozumab Compared With Teriparatide 9Emerus Announces Significant Strategic Investment By Welsh, Carson, Anderson & Stowe 2Emerus Announces Significant Strategic Investment By Welsh, Carson, Anderson & Stowe 3
Cached News: