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Studies link obesity to increased frequency of heartburn symptoms; greater risk of esophageal cancer

of 1,103 patients with esophageal cancer, seven studies found obesity to be a risk factor; two found no association. Four studies found a significant dose-dependent association between body mass index and risk. As BMI increased so did risk of esophageal adenocarcinoma.

Dr. Pohl and Dr. Robertson found those in the highest BMI group were 3.5 times more likely to develop esophageal adenocarcinoma than patients in the lowest BMI group, which included individuals of normal weight. Adjusting for other possible risk factors such as GERD, smoking or a diet low in vegetables, had minimal affect on this outcome.


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Contact: Malaika Hilliard
mhilliard@porternovelli.com
202-973-5896
American College of Gastroenterology
1-Nov-2004


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