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Studies show ACTOS(R) (pioglitazone HCl) has positive effects on various components of dyslipidemia

y significant decreases in both systolic and diastolic blood pressure were noted in the ACTOS monotherapy and ACTOS/sulfonylurea groups.

A second study presented at the ADA Scientific Sessions demonstrated that, in people with type 2 diabetes and dyslipidemia, ACTOS had a robust effect on both lipid and glucose levels, regardless of whether the patient was receiving stable lipid-lowering therapy. People with diabetes are about twice as likely as those without diabetes to have high triglyceride and low HDL cholesterol levels, a condition commonly referred to as diabetic dyslipidemia.

In this study of 859 patients with type 2 diabetes, 736 were taking statins and 123 were taking fibrates, both of which are established therapies to treat dyslipidemia. These patients were matched with controls that were not taking lipid-lowering drugs and all participants were given ACTOS (30 mg/day) for 16 weeks.

Significant beneficial effects of ACTOS were seen on HDL ("good") cholesterol, fasting triglycerides, non-HDL cholesterol (total cholesterol minus HDL-C) and A1C (a measure of average blood glucose levels over the previous 90 to 120 days). Additionally, the benefits seen with ACTOS were not significantly influenced by the patient's age, diabetes duration, body mass index or gender.

About ACTOS

ACTOS is an oral treatment for type 2 diabetes belonging to the thiazolidinedione class of drugs. It is known as an "insulin sensitizer" because it directly targets insulin resistance, a condition in which the body does not effectively use the insulin it produces. It is taken once daily as an adjunct to diet and exercise, and is approved for use as monotherapy to lower blood glucose and in combination therapy with insulin, sulfonylureas or metformin.

Additional Information

ACTOS is not for everyone. ACTOS can cause fluid retention or edema (swelling), which may lead to or worsen heart failure, so tell your doctor i
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Contact: Julio Cantre
julio.cantre@ketchum.com
646-935-4122
Ketchum
6-Jun-2004


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