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Studies show Tim-3 proteins key to immune responses

cells, which could prove to be an important application when used in vaccine development, for example.

"From a therapeutic perspective, the implications of these new findings are intriguing," says Strom.

The Strom study was funded by the Juvenile Diabetes Research Foundation, the National Institute of Allergy and Infectious Diseases and the Center for Islet Transplantation at Harvard Medical School; the Kuchroo study was funded by the National Multiple Sclerosis Society and the National Institutes of Health.

Co-authors of the Strom paper include lead investigator Alberto Sanchez-Fueyo, MD, Christoph Domenig, MD, and Xin Xiao Zheng, MD, of Beth Israel Deaconess Medical Center; Jane Tian, Dominic Picarella, Jose-Carlos Gutierrez-Ramos, PhD, and Anthony Coyle, PhD, of Millennium Pharmaceuticals, Cambridge, Mass.; Catherine Sabotos, MSc, and Vijay Kuchroo, DVM, PhD, of Brigham and Women's Hospital; Natasha Manlongat of Hammersmith College, London; and Orissa Bender and Thomas Kamradt of Deutsches Rheumaforschungs Zentrum, Berlin. Co-authors of the Kuchroo paper, in addition to Catherine Sabotos, MSc, include BWH researchers Sumone Chakravarti, PhD, Eugene Cha, BA, and Anna Shubart, PhD; and Gordon Freeman of the Dana-Farber Cancer Institute.


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Contact: Bonnie Prescott
bprescot@bidmc.harvard.edu
617-667-7306
Beth Israel Deaconess Medical Center
30-Oct-2003


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