HOME >> MEDICINE >> NEWS
Study: New neurons can get out of spinal cord

In experiments with rodents, Johns Hopkins scientists have used properly directed stem cells to successfully overcome what is thought to be a basic hurdle in restoring function to severely damaged central nervous systems -- getting new motor neurons to migrate through the spinal cord.

In their experiments, the researchers first coaxed embryonic stem cells from mice to begin their transformation into motor neurons. Once these "pre-motor neurons" were implanted into the spinal cords of paralyzed rats, a constant drip of molecules that block the nerve-repelling activity of the spinal cord's myelin sheath gave the cells a chance to break through.

About 80 of an initial 12,000 neurons-in-training implanted into each rat became full-fledged motor neurons and pushed their finger-like extensions, called axons, through the spinal cord, the researchers reported April 26 in the Advance Online section of the Proceedings of the National Academy of Sciences.

"We think that getting new motor neurons to travel properly through the cord is the major hurdle to try to restore muscle control," says Douglas Kerr, M.D., Ph.D., an assistant professor of neurology. "It's significant that axons from these motor neurons make it outside of the cord."

However, he cautions that much remains before stem cells or cells derived from them could be useful for restoring lost or "broken" neurons in people. For example, in their experiments, even though some of the new neurons reached through the myelin coating, they didn't get much farther down the road to the real target -- muscles.

Furthermore, to approach therapy, Kerr says, these and other experiments need to be done with human embryonic stem (ES) cells that may one day be clinically useful. However, the human ES cell lines approved for research under federal grants -- by far the largest source of funding for academic researchers -- have been grown in the presence of mouse cells, which many scientists bel
'"/>

Contact: Joanna Downer
jdowner1@jhmi.edu
410-614-5105
Johns Hopkins Medical Institutions
27-Apr-2004


Page: 1 2 3

Related medicine news :

1. Study: Two brain systems regulate how we call for help
2. Study: Eye contact triggers threat signals in autistic childrens brains
3. Study: Young adults can be motivated to eat fruits, veggies
4. Study: Physical activity in middle age cuts risk of early death
5. Study: Brain battles itself over short-term rewards, long-term goals
6. Study: Dementia often undiagnosed in clinical settings
7. Study: Too few doctors ask teens about smoking
8. Study: Low-carb diet more effective than low-fat diet
9. Study: Many men take dietary supplements to prevent prostate cancer
10. Study: Height loss screen ultimately could reduce hip fractures
11. Study: Carbon dioxide may find new use in producing medical implants

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/11/2018)... ... ... Johns Hopkins All Children’s Hospital will make a broader commitment to ensuring ... perspective on care. At its core, this perspective focuses on ways to improve health ... or setting at the right cost. Mark Douglas "Doug" Baker, M.D., will focus on ...
(Date:8/11/2018)... (PRWEB) , ... August 11, 2018 , ... ... of a Silver Stevie® Award in the Executive of the Year-Business category in ... world’s premier business awards program. All individuals and organizations worldwide – public and ...
(Date:8/9/2018)... ... August 09, 2018 , ... Lyme disease is one of ... skyrocketing to an estimated 329,000 – a 25-fold increase since surveillance began in 1982. ... can be found all 50 states and the District of Columbia. Yet, Lyme and ...
(Date:8/9/2018)... ... August 09, 2018 , ... ... medication adherence monitoring with Smart-pill bottle and mobile applications, DoseSmart announced today ... Orchard. , The DoseSmart medication management and medication adherence platform helps hospitals ...
(Date:8/9/2018)... ... August 09, 2018 , ... ... Coover and the company’s independent distributors, customers, and employees, the newly established ... fundraising, exceeding the $2 million goal. 100 percent of the donations will fund ...
Breaking Medicine News(10 mins):
(Date:8/11/2018)... ... 10, 2018 , ... US Capital Global has been retained by ... round. Carepoynt is an emerging leader in the digital health field. The company is ... engaging healthcare ecosystem. , Headquartered in San Francisco, US Capital Global is a full-service ...
(Date:8/9/2018)... ... August 09, 2018 , ... Autism is a developmental disorder affecting more than ... is, (approximately 1 in 68 people have the disorder), chances are you know someone ... teach a child with autism methods of communication and tactics to interact with others. ...
(Date:8/7/2018)... ... August 07, 2018 , ... Commissioner Gottlieb’s FDA:, Analysis of First ... – 3:00 p.m. ET, http://www.fdanews.com/commissionergottliebsfda , Under Commissioner Scott Gottlieb, changes ... have benefited, some may have gotten hurt. , And Gottlieb is just getting started. ...
Breaking Medicine Technology:
Cached News: