Study Reveals Gender Affects Lung-Cancer Development

DALLAS - April 21, 1999 - Once again evidence says that differences exist between the sexes. Researchers have discovered that men and women may not in fact be equal - at least with respect to the pattern of precancerous lesions in the lungs of current and former smokers.

Dr. Adi Gazdar, UT Southwestern professor of pathology, Dr. Stephen Lam and colleagues in Canada and other investigators at the National Cancer Institute in Bethesda, Md., have published the first study that analyzes the gender differences in precancerous changes in smokers' lung tissue. This study, in the April 21 issue of the Journal of the National Cancer Institute, finds that women develop a different pattern of bronchial changes than men do; that airflow obstruction, a common means to assess those at risk of lung cancer, does not seem to be valid especially for women; and that lung damage due to smoking persists for many years and probably for life.

More men and women die from lung cancer than from any other type of cancer. This year an estimated 171,600 new cases of lung cancer will be diagnosed, and 158,000 people will die from this disease. Approximately 50 percent of lung cancer occurs in former smokers. Women are more susceptible to the harmful effects of tobacco-related carcinogens - the odds ratios for major types of lung cancer are consistently higher in women than in men at every level of exposure to cigarette smoke. Furthermore, this gender difference cannot be explained by differences in baseline exposure, smoking history or body size; it is likely due to women's higher susceptibility to tobacco carcinogens.

"Cancer is the result of a complex multistep process," said Gazdar, associate director of the Nancy B. and Jake L. Hamon Center for Therapeutic Oncology Research. "We are actively trying to develop methods of early detection and chemoprevention - ways to chemically reverse precancerous lesions and block cancer development - for those at high risk."

The scienti

Contact: Heather Stieglitz
UT Southwestern Medical Center

Page: 1 2

Related medicine news :

1. Study of energy and health in Africa focuses spotlight on charcoal and forest management
2. Study shows promise in identifying kidney failure
3. Study shows patch therapy may be as effective as oral medications
4. Study shows soy is well accepted in school lunches
5. Study finds that coordinating care of chronically ill patients does not increase liability
6. Study provides new estimates of the causes of child mortality worldwide
7. Study finds factors linked to substance use disorder relapse among health care professionals
8. Study finds majority of women willing to accept cervical cancer vaccine for self and children
9. Study shows use of budesonide reduced the risk of asthma related events by 40% in children
10. Study shows risk of cardiac death after radiation for breast cancer has dramatically decreased
11. Study shows acrylamide in baked and fried food does not increase risk of breast cancer in women

Post Your Comments:

(Date:8/31/2020)... (PRWEB) , ... August 31, 2020 , ... In an ... West Loop is donating 10 percent of each hotel room booked with a ... Charities® of Chicagoland & Northwest Indiana (RMHC-CNI) , effective immediately. Donations will be ...
(Date:8/31/2020)... (PRWEB) , ... August 31, 2020 , ... ... intended to improve outcomes for patients with advanced heart failure, today announced that ... grant in the amount of $555,358 from the National Heart, Lung, and Blood ...
(Date:8/28/2020)... ... August 28, 2020 , ... Ernst ... Mandeville was named an Entrepreneur Of The Year® 2020 Florida Award finalist. Now ... leaders whose ambitions deliver innovation, growth and prosperity as they build and sustain ...
(Date:8/28/2020)... ... August 28, 2020 , ... The 15 ... customized Lighthouse Health & Wellness mobile app and web-portal. NCPCV received a 2020 ... Foundation awards grants each year to organizations, such as Destination Imagination, which support ...
(Date:8/28/2020)... ... 2020 , ... Integrated Viral Protection (IVP Air) today announced that ... its breakthrough Mobile Biodefense Indoor Air Protection System that is the first system designed ... fully reopen equipped with the filtration system on September 8th. , The IVP ...
Breaking Medicine News(10 mins):
(Date:8/28/2020)... ... August 28, 2020 , ... Dr. Mark Surrey has been in practice ... as a clinical professor in the Department of OBGYN at UCLA’s David Geffen School ... Pacific Coast Reproductive Society and is a Clinical Director of Fellowship Training for UCLA ...
(Date:8/27/2020)... ... August 27, 2020 , ... ... today announced the successful completion of their 2020 System and Organizational Controls (SOC) ... HITRUST® interim assessment and MARS-E compliance assessment. These achievements reflect their long-standing commitment ...
(Date:8/27/2020)... ... , ... The flu season is right round the corner and the risk of getting caught ... measures before it begins to harbor its effects on us. Already with the sudden outbreak ... impact on our lives. Hence it has become even more relevant to keep oneself immune ...
Breaking Medicine Technology:
Cached News: