HOME >> MEDICINE >> NEWS
Study affirms safety of oxaliplatin for colorectal patients with advanced cancer

PITTSBURGH, July 31 Results from a large multi-site study led by University of Pittsburgh Cancer Institute (UPCI) researcher, Ramesh Ramanathan, M.D., and published in the Aug. 1 issue of the Journal of Clinical Oncology demonstrate that the drug oxaliplatin is safe for patients with advanced colorectal cancer.

"Our results are encouraging because they affirm that oxaliplatin is safe for patients with advanced colorectal cancer," said Dr. Ramanathan, lead investigator and associate professor in the division of hematology/oncology at the University of Pittsburgh School of Medicine. "We found a relatively low occurrence of toxicity from treatment regimens that included oxaliplatin indicating that it may be a promising option for colorectal patients."

Dr. Ramanthan, also director of UPCI's gastrointestinal cancer center, added that these results are important given the dire need for therapies for patients with advanced colorectal cancer who have failed first-line treatment.

The current study included 5,176 patients with locally advanced or metastatic colorectal cancer who did not respond to at least one prior chemotherapy regimen containing fluorouracil (FU), the most common therapy administered to colorectal cancer patients.

Patients enrolled in the study received oxaliplatin as a single-agent or oxaliplatin in combination with FU, with or without leucovorin (LV). Results indicated that the incidence of high-grade gastrointestinal side effects was lowest (18 percent) in patients who received oxaliplatin in combination with FU and LV, compared to incidences of 28 to 33 percent in the other regimens. Patients who received oxaliplatin alone had the lowest incidence of hospitalization. Overall, the results demonstrated a relatively low occurrence of blood toxicity (25 percent) and gastrointestinal toxicity (24 percent) and a less than 1 percent incidence of death from treatment-related adverse events. In addition, oxaliplatin dose-inten
'"/>

Contact: Clare Collins
412-647-3555
University of Pittsburgh Medical Center
31-Jul-2003


Page: 1 2

Related medicine news :

1. Study of energy and health in Africa focuses spotlight on charcoal and forest management
2. Study shows promise in identifying kidney failure
3. Study shows patch therapy may be as effective as oral medications
4. Study shows soy is well accepted in school lunches
5. Study finds that coordinating care of chronically ill patients does not increase liability
6. Study provides new estimates of the causes of child mortality worldwide
7. Study finds factors linked to substance use disorder relapse among health care professionals
8. Study finds majority of women willing to accept cervical cancer vaccine for self and children
9. Study shows use of budesonide reduced the risk of asthma related events by 40% in children
10. Study shows risk of cardiac death after radiation for breast cancer has dramatically decreased
11. Study shows acrylamide in baked and fried food does not increase risk of breast cancer in women

Post Your Comments:
(Date:5/24/2013)... Florida (PRWEB) May 24, 2013 KC and ... the Title Sponsors for FreeRide836. Their oldest sons, Kyle and ... and Tracey Russell family and several professional kiteboarders. , KC ... amazing project. "This has miraculously come together such that virtually ... able to participate." , 20 kite boarders will meet at ...
(Date:5/24/2013)... May 24, 2013 CHI-California Healthcare ... and the California congressional delegation, joined by over ... industry user fees paid to the U.S. Food ... that future across-the-board cuts will not include user ... FY14 Agriculture, Rural Development and FDA Appropriations Bill. ...
(Date:5/24/2013)... failed to replicate what appeared to be breakthrough results ... were published last year in the journal Science ... suggested that the drug bexarotene (marketed as Targretin) could ... a pathological hallmark of Alzheimer,s disease in ... the 2012 report, drug treatment quickly removed most of ...
(Date:5/24/2013)... to the development of infantile myofibromatosis (IM)a disorder characterized ... tissuemay provide new therapeutic targets, according to researchers from ... findings, published in the American Journal of Human ... this debilitating disease, for which the only current treatment ... IM is an inheritied disorder that develops in infancy ...
(Date:5/24/2013)... (HealthDay News) -- Low-income, minority parents have more ... are more open to vaccinating their daughters against ... new study contends. Conversely, white, middle-class parents ... their daughters, according to researchers from the Boston ... will get an HPV-related cancer each year, many ...
Breaking Medicine News(10 mins):Health News:FreeRide836 Sponsor Living Fuel, The Leader in Superfood Nutrition, Announces Kiteboard Launch For This Sunday To Raise Money For Orphans In Africa 2Health News:FreeRide836 Sponsor Living Fuel, The Leader in Superfood Nutrition, Announces Kiteboard Launch For This Sunday To Raise Money For Orphans In Africa 3Health News:California Biomedical Industry Leaders Urge Congress to Take Action on FDA User Fees for FY2014 2Health News:California Biomedical Industry Leaders Urge Congress to Take Action on FDA User Fees for FY2014 3Health News:Multiple research teams unable to confirm high-profile Alzheimer's study 2Health News:Multiple research teams unable to confirm high-profile Alzheimer's study 3Health News:Researchers identify first drug targets in childhood genetic tumor disorder 2Health News:Low-Income, Minority Parents More Open to HPV Vaccine for Girls, Study Says 2
(Date:5/23/2013)... Amgen (NASDAQ: AMGN ) will present ... on Thursday, May 30, 2013, at the Westin Boston Waterfront ... Eastern Daylight Time. Arvind Sood , vice ... conference. Live audio of the presentation can be accessed from ... Investors. A replay of the webcast will also be available ...
(Date:5/23/2013)... Hearing health affects a man,s lifestyle, and if he wants ... engaged, he should address any hearing loss he may be ... Hearing Institute (BHI) is delivering to men around the ... which leads up to and includes Father,s Day. This year, ... 16. To help men address their hearing ...
(Date:5/23/2013)... , May 23, 2013  TeamHealth Medical ... nurse triage and nurse advice lines, announces its ... comprising physician, nursing and administrative leaders, provides clinical ... quality and cost-effective services for hospital clients, physician ... national healthcare system evolves, it,s imperative to continuously ...
Breaking Medicine Technology:Men Who Want to Stay Active, Feel Younger, and Remain Socially and Professionally Engaged Should Address Hearing Loss, BHI Advises 2Men Who Want to Stay Active, Feel Younger, and Remain Socially and Professionally Engaged Should Address Hearing Loss, BHI Advises 3Men Who Want to Stay Active, Feel Younger, and Remain Socially and Professionally Engaged Should Address Hearing Loss, BHI Advises 4TeamHealth Medical Call Center Forms Clinical Advisory Committee 2
Cached News: