Study assessing once daily Abacavir (ABC) in a once daily ART regimen

Chicago, Sept. 16, 2003 Studies supporting the efficacy of a once daily (QD) antiretroviral (ART) therapy regimen and the QD dosing of Ziagen (abacavir sulfate) (ABC) were presented here today at the 43rd Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC).

CNA30021 Studies QD Regimen

A multicenter, randomized study of HIV-infected ART nave adults compared the virologic response of 600mg QD and 300mg twice daily (BID) regimens of abacavir (in a double-blind manner), each in combination with open-label Epivir (lamivudine) (3TC) 300mg QD and efavirenz (EFV) 600mg QD.

The ABC QD dosing regimen provided an antiretroviral response over 48 weeks that was shown to be non-inferior to the approved ABC BID dosing regimen, according to study results.

"There are a number of antiretroviral drugs that have now received FDA approval to be dosed once a day, but because of drug interactions or food requirements, finding a combination that is 'truly' QD with a patient taking all his ART medications at one time, once a day has been daunting," said Doug Manion, M.D., GSK vice president of clinical development. "It has been GSK's goal to test our established drugs to determine if the data would support their use QD, providing greater flexibility for patients and physicians. Epivir is already approved to be dosed once a day and the data from the two studies being presented at ICAAC this week provide additional insight into QD dosing of Ziagen. If you add in efavirenz, which is also given once daily, a true QD regimen appears possible with patients being able to take three ART pills once a day."

In the study of 770 individuals, 66 percent in the ABC QD group versus 68 percent in the ABC BID group achieved and maintained plasma HIV-1 RNA of <50 copies/mL through 48 weeks. Virologic failure was infrequent and similar between the treatment groups (10 percent in the QD group versus 8 percent in the BID group). Patients at basel

Contact: Elaine Salewske
Public Communications Inc.

Page: 1 2 3 4 5

Related medicine news :

1. Study of energy and health in Africa focuses spotlight on charcoal and forest management
2. Study shows promise in identifying kidney failure
3. Study shows patch therapy may be as effective as oral medications
4. Study shows soy is well accepted in school lunches
5. Study finds that coordinating care of chronically ill patients does not increase liability
6. Study provides new estimates of the causes of child mortality worldwide
7. Study finds factors linked to substance use disorder relapse among health care professionals
8. Study finds majority of women willing to accept cervical cancer vaccine for self and children
9. Study shows use of budesonide reduced the risk of asthma related events by 40% in children
10. Study shows risk of cardiac death after radiation for breast cancer has dramatically decreased
11. Study shows acrylamide in baked and fried food does not increase risk of breast cancer in women

Post Your Comments:

(Date:5/14/2019)... ... 2019 , ... Impact Advisors, a leading provider of clinical, ... John Stanley, Vice President, has been named one of the “Top 25 Consultants” ... has been recognized in the Excellence in Healthcare category. He will attend the ...
(Date:5/14/2019)... (PRWEB) , ... May 14, 2019 , ... A high ... one of the top health crises in the Houston area and the southern United ... Hispanic men who have sex with men (MSM) and transgender people ...
(Date:5/14/2019)... NASHVILLE, Tenn. (PRWEB) , ... May 14, 2019 ... ... announced today the availability of the Relatient® eRegistration and Check-In solution , ... prior to an appointment. The solution builds on Relatient’s Patient Engagement ...
(Date:5/14/2019)... ISLIP, N.Y. (PRWEB) , ... May 14, 2019 ... ... That’s the price tag put on anti-aging products and procedures, according to market ... registered Physician Assistant specializing in Dermatology with Advanced Dermatology PC , “but ...
(Date:5/14/2019)... ... ... Dr. Steven Shoshany has been treating patients experiencing both acute and long ... therapy device, becoming the first chiropractor in Manhattan to do so. Since January, Dr. ... for treating pain and injuries, into his downtown practice. He recently finished designing a ...
Breaking Medicine News(10 mins):
(Date:5/16/2019)... , ... May 16, 2019 , ... Join John Cogan, ... David Berglund, Global Head Regulatory Operations at AstraZeneca in a live webinar ... technologies can modernize Regulatory Information Management (RIM) systems. , As Regulatory Operating models ...
(Date:5/15/2019)... ... May 15, 2019 , ... Claudius Moore, a seasoned technology ... of Information Technology. Over the last 15 years, Moore has mastered a method ... also creating a high-quality, efficient experience for patients. , Moore will lead AFC’s ...
(Date:5/15/2019)... , ... May 15, 2019 , ... ... Customer Success Report to give prospects better insight on which Emergency Mass ... , The highest rated vendors according to the 2019 Spring Emergency Mass Notification ...
Breaking Medicine Technology:
Cached News: