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Study demonstrates improved survival in women with metastatic breast cancer

disease progression (time without the cancer growing) and overall survival. In the "intent to treat" population, results are as follows:

  • Median survival was 15.4 months for Taxotere and 12.7 months for paclitaxel (P-value = 0.03).

  • Median time to disease progression for patients treated with Taxotere was 5.7 months compared to 3.6 months for those treated with paclitaxel (P-value = <0.0001).

  • Response rates were numerically higher for Taxotere (32.0%) compared to paclitaxel (25.0%), with P-value=0.10. The overall response rate was statistically significant for Taxotere (37.4%) compared to paclitaxel (26.4%) in the "eligible and evaluable" population (P-value=0.02).

Taxotere was associated with increased incidence of grade 3/4 toxicities, including neutropenia (decrease in white blood cells which help fight infection), fever, diarrhea and edema (fluid retention).

"The study builds upon our base of research and provides additional support that Taxotere is one of the most active chemotherapy agents in the treatment of metastatic breast cancer after the failure of prior chemotherapy," said Michael L. Meyers, Senior Director, Oncology, Medical Affairs, Aventis Pharmaceuticals.


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Contact: Arleen Goldenberg
Arleen_Goldenberg@nyc.cohnwolfe.com
212-798-9749
Cohn & Wolfe
24-Sep-2003


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