HOME >> MEDICINE >> NEWS
Study finds HER2-positive breast cancer invades organs due to fatal chemical attraction

HOUSTON - Researchers at The University of Texas M. D. Anderson Cancer Center have solved the mystery of why an aggressive form of HER2-positive breast cancer travels readily to a few key organs - lungs, liver and bone -where it then establishes new tumors. They say this finding may lead to strategies to block that deadly spread.

The study, published in the November issue of Cancer Cell, describes a lethal attraction between signals found on HER2-positive breast cancer cells and those on the surface of the organs -a magnetism that explains why this form of breast cancer, which affects up to 30 percent of patients, can be so invasive. The vast majority of women who die from HER2-positive breast cancer had developed secondary tumors in their lung, liver and bones.

"It has always been a puzzle as to why, when HER2-positive cancer cells circulate throughout the body looking for a new home, they preferentially travel to these organs," says the study's lead author, Mien-Chie Hung, Ph.D., a professor and chair of the Department of Molecular & Cellular Oncology. "We now have explained it biochemically, and hope that this leads to strategies that prevent such metastasis."

Their discovery focuses on the relationship between HER2 and chemokine receptor proteins on breast cancer cells. Chemokines are a large family of proteins primarily known to speed inflammatory responses by drawing them to circulating white blood cells that have a corresponding chemokine receptor. Researchers have found that some diseases, including HIV and cancer, use this same chemical attraction to invade the body.

Although scientists already had discovered that the chemokine receptor CXCR4 was involved in the movement of certain forms of breast cancer to target organs, they did not know how CXCR4 did that for HER2-postive breast cancer until now.

The M. D. Anderson team specifically found breast cancer that overexpress HER2 proteins also ramp up production
'"/>

Contact: Nancy Jensen
nwjensen@mdanderson.org
713-792-0655
University of Texas M. D. Anderson Cancer Center
15-Nov-2004


Page: 1 2 3

Related medicine news :

1. Study of energy and health in Africa focuses spotlight on charcoal and forest management
2. Study shows promise in identifying kidney failure
3. Study shows patch therapy may be as effective as oral medications
4. Study shows soy is well accepted in school lunches
5. Study finds that coordinating care of chronically ill patients does not increase liability
6. Study provides new estimates of the causes of child mortality worldwide
7. Study finds factors linked to substance use disorder relapse among health care professionals
8. Study finds majority of women willing to accept cervical cancer vaccine for self and children
9. Study shows use of budesonide reduced the risk of asthma related events by 40% in children
10. Study shows risk of cardiac death after radiation for breast cancer has dramatically decreased
11. Study shows acrylamide in baked and fried food does not increase risk of breast cancer in women

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/13/2017)... ... , ... The Visiting Nurse Association (VNA) of Somerset Hills is proud to ... unique items from across the nation, this holiday-themed event will raise funds and awareness ... VNA. The boutique will be open Saturday, November 4 (10:00 a.m. – 5:00 ...
(Date:10/13/2017)... , ... October 13, 2017 , ... Yisrayl Hawkins, Pastor ... that explains one of the most popular and least understood books in the Holy ... and puzzling descriptions that have baffled scholars for centuries. Many have tossed it off ...
(Date:10/13/2017)... ... ... Journey: From the Mountains to the Mission Field”: the story of a missionary couple ... From the Mountains to the Mission Field” is the creation of published author, Carole ... and currently teaches a class of ladies at her church, which she has taught ...
(Date:10/12/2017)... San Francisco, CA (PRWEB) , ... October 12, ... ... and Dr. Cheng, are now treating sleep apnea using cutting-edge Oventus ... sleep apnea, a serious sleep disorder characterized by frequent cessation in breathing. Oral ...
(Date:10/12/2017)... ... October 12, 2017 , ... IsoComforter, Inc. ( https://isocomforter.com ... the introduction of an innovative new design of the shoulder pad. The shoulder ... maximum comfort while controlling your pain while using cold therapy. By utilizing ice and ...
Breaking Medicine News(10 mins):
(Date:10/4/2017)...  South Korean-based healthcare product Development Company I.M. Lab ... Kickstarter. The device will educate the user about ,proper, ... efficiency compared to the dated and pricey CPR training ... of the compression for a more informed CPR training. ... raise $5,000. cprCUBE ...
(Date:10/2/2017)... Mich. , Oct. 2, 2017 Diplomat ... 8th Day Software and Consulting, LLC , and ... 8th Day Software, based in Tennessee ... LLC. 8th Day expands EnvoyHealth,s service offerings for health ... development. "In an ...
(Date:10/2/2017)... , Oct. 2, 2017 Halo Labs announces the European ... system called the HORIZON at MIBio 2017 in Cambridge, ... and visible particulate matter in biopharmaceutical samples with unprecedented speed and ... the novel technique Backgrounded Membrane Imaging. ... The HORIZON subvisible particle analysis system ...
Breaking Medicine Technology:
Cached News: