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Study finds new designer drug is potent treatment for chronic myelogenous leukemia

eevec. Side effects in the animals were minimal.

Synthesized in August 2002, AMN107 entered early Phase I clinical studies in May 2004 21 months later. Data presented last December at the American Society of Hematology showed that AMN107 had demonstrated significant clinical activity in the most challenging setting: Gleevec resistant accelerated and blast crisis CML patients.

"We're very encouraged by the results so far," remarks Griffin, who is also a professor of medicine at Harvard Medical School. "This is an elegant example of how rational drug design developing drugs based on a molecular understanding of cell structures and processes can be used to attack human diseases."

The findings contribute to a larger Dana-Farber research effort, dubbed the "Kinase Project," which seeks to identify abnormal tyrosine kinases -- enzymes that spark or halt growth -- in cancer cells and test agents known to act against them.

The Cancer Cell study's lead author is Ellen Weisberg, PhD, of Dana-Farber. Co-authors include researchers at Dana-Farber, Novartis, Brigham and Women's Hospital, and Children's Hospital Boston.


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Contact: Bill Schaller
617-632-4090
Dana-Farber Cancer Institute
18-Feb-2005


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