Study finds obesity not associated with efficacy of tamoxifen for early-stage breast cancer

Obesity is not associated with an increased risk of recurrence among women with early-stage, hormone-responsive breast cancer and does not appear to decrease the effectiveness of the drug tamoxifen, according to a study in the October 1 issue of the Journal of the National Cancer Institute.

Earlier studies had suggested an increased risk of recurrence and death among obese women compared with lean women. However, these studies included women with different stages of breast cancer, note study leader James J. Dignam, Ph.D., of the University of Chicago, and his colleagues. Obesity is associated with a more advanced stage of disease, and this could account for the observed increase in risk of recurrence and death among obese women, the researchers say.

In this study, Dignam and his colleagues looked specifically at women with early-stage, hormone-responsive disease. Their study involved 3,385 women enrolled in a randomized, placebo-controlled study to evaluate the effectiveness of tamoxifen after surgery. The authors examined the association between obesity (defined as having a body mass index of 30.0 kg/m2 or higher) and risks of breast cancer recurrence, of contralateral (opposite) breast tumors, of other new primary cancers, and of overall mortality.

After a median follow-up time of 166 months (13.8 years), obese women had no higher risk of recurrence or deaths attributable to breast cancer than lean women. However, obesity was associated with increased risks of cancer in the contralateral breast, of other primary cancers, and of all-cause mortality. Tamoxifen reduced breast cancer recurrence and mortality to a similar degree, regardless of body mass index.

The authors point out that their study did not consider weight or obesity at different periods of life, including adolescence and early adulthood. And they did not have information about socioeconomic measures, dietary history, and other factors that may have contributed

Contact: Linda Wang
Journal of the National Cancer Institute

Page: 1 2

Related medicine news :

1. Study of energy and health in Africa focuses spotlight on charcoal and forest management
2. Study shows promise in identifying kidney failure
3. Study shows patch therapy may be as effective as oral medications
4. Study shows soy is well accepted in school lunches
5. Study finds that coordinating care of chronically ill patients does not increase liability
6. Study provides new estimates of the causes of child mortality worldwide
7. Study finds factors linked to substance use disorder relapse among health care professionals
8. Study finds majority of women willing to accept cervical cancer vaccine for self and children
9. Study shows use of budesonide reduced the risk of asthma related events by 40% in children
10. Study shows risk of cardiac death after radiation for breast cancer has dramatically decreased
11. Study shows acrylamide in baked and fried food does not increase risk of breast cancer in women

Post Your Comments:

(Date:12/14/2018)... ... 14, 2018 , ... Our competitor knew for decades that ... claim its talc powder has toxic ingredients that may cause cancer and mesothelioma, ... powder. The documents also show our competitor's leadership intentionally hid their knowledge of ...
(Date:12/14/2018)... ... December 14, 2018 , ... Art of Dentistry leaders ... are helping patients in La Mesa, CA interested in cosmetic dentistry and rejuvenating their ... teeth and gums are not aesthetically appealing because of decay, damage, or other issues. ...
(Date:12/13/2018)... ... December 13, 2018 , ... ... visibility, operational efficiency and financial outcomes, introduced new enhancements to its NetSolutions™ platform. ... and financial leadership, rather than technology and screen time. , Enhancements made ...
(Date:12/13/2018)... BUFFALO, N.Y. (PRWEB) , ... December 13, 2018 , ... ... exercise regularly both before and after their diagnosis are significantly more likely to survive ... activity is an important part of a cancer prevention and treatment strategy. The results ...
(Date:12/13/2018)... ... December 13, 2018 , ... Evergreen Healthcare Partners is ... brings over 20 years of leadership experience in healthcare technology, consulting, project management ... strong teams and creating vibrant cultures of personal growth and development. In her ...
Breaking Medicine News(10 mins):
(Date:12/13/2018)... ... December 13, 2018 , ... Sponsorship and exhibitor opportunities are ... May 2 to 4 at the Swissotel in Chicago. The event focuses on ... the best use of artificial intelligence, telehealth, data analytics, clinician burnout, population health ...
(Date:12/10/2018)... ... December 10, 2018 , ... Parkstone Growth Partners (“Parkstone”) ... Parkview Dental Partners (“Parkview Dental”), a dentist-founded dental growth and management partnership. Parkview ... a group dental practice comprised of 16 dentists and hygienists across eight offices ...
(Date:12/10/2018)... ... 2018 , ... Over the years, Eye Institute of New York has built ... services, and personalized care. The affiliation with OCLI will allow the office to further ... recently became the sixth affiliation of Spectrum Vision Partners’ managed practices since November 2017, ...
Breaking Medicine Technology:
Cached News: