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Study in male smokers continues to provide clues into the causes and prevention of multiple cancers

SEATTLE The Alpha-Tocopherol, Beta-Carotene Cancer Prevention (ATBC) Study was initiated to test the effect of vitamin supplementation on the prevention of lung and other cancers. The trial ended in 1993, but ongoing follow-up of the participants continues, offering new insights into the causes and prevention of multiple diseases, including cancer.

Results from two separate sub-studies in ATBC, presented today at the American Association for Cancer Research Third Annual International Conference on Frontiers in Cancer Prevention Research, may provide new information into the causes of prostate cancer and the prevention of stomach cancer. In the first study, a team of researchers found a link between men's height and their risk level for advanced prostate cancer. In the second study, researchers present critical evidence of the impact of fruit, vegetables, and antioxidant nutrient consumption on the risk of stomach cancer.

A Prospective Investigation of Height and Prostate Cancer Risk in Male Smokers (Abstract 223) Tall men may be at an increased risk for prostate cancer and clinically advanced forms of the disease, according to new research from U.S. and Finnish investigators.

The results showed that the tallest men experienced a 20 percent increased risk for prostate cancer, which is considered a modest increase in risk. Of the 29,000 participants in this group, some 1,346 prostate cancer cases were identified during 17.4 years of follow-up studies.

However, when this relationship was analyzed according to how far the cancer had spread, the team found a strong association between height and clinically advanced disease. In fact, the tallest men were twice as likely to get prostate cancer as the shortest men in the study group. "Our results help to clarify previous inconsistencies in the literature, and offer some insights into the etiology of prostate cancer. However, the biological mechanism
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Contact: Warren Froelich
communications@aacr.org
206-219-4772
American Association for Cancer Research
17-Oct-2004


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